Abstract：
:Traumatic brain injury (TBI) is a major cause of acquired disability globally, and effective treatment methods are scarce. Lately, there has been increasing recognition of the devastating impact of TBI resulting from sports and other recreational activities, ranging from primarily sport-related concussions (SRC) but also more severe brain injuries requiring hospitalization. There are currently no established treatments for the underlying pathophysiology in TBI and while neuro-rehabilitation efforts are promising, there are currently is a lack of consensus regarding rehabilitation following TBI of any severity. In this narrative review, we highlight short- and long-term consequences of SRCs, and how the sideline management of these patients should be performed. We also cover the basic concepts of neuro-critical care management for more severely brain-injured patients with a focus on brain oedema and the necessity of improving intracranial conditions in terms of substrate delivery in order to facilitate recovery and improve outcome. Further, following the acute phase, promising new approaches to rehabilitation are covered for both patients with severe TBI and athletes suffering from SRC. These highlight the need for co-ordinated interdisciplinary rehabilitation, with a special focus on cognition, in order to promote recovery after TBI.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Marklund N,Bellander BM,Godbolt AK,Levin H,McCrory P,Thelin EPdoi
10.1111/joim.12900subject
Has Abstractpub_date
2019-06-01 00:00:00pages
608-623issue
6eissn
0954-6820issn
1365-2796journal_volume
285pub_type
杂志文章,评审abstract：:This study was conducted to determine the relative importance of efferent muscle sympathetic nerve activity (MSA), vasopressin (ADH) and atrial natriuretic peptide (ANP) in the short-term neurohumoral response to moderate changes in low-pressure cardiopulmonary receptor activity. The low-pressure receptors were stimul...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1991.tb00323.x
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVES:To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN:Retrospective study. SETTING:University Hospital of Malmö, Sweden. SUBJECTS:A total of 59 patients with ileocolonic, ileocaecal or colonic Croh...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1998.00246.x
更新日期：1998-02-01 00:00:00
abstract：:Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency, and by reducing surgical trauma, several observational studies suggest potentia...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12974
更新日期：2019-12-01 00:00:00
abstract：:Cerebral toxoplasmosis is optimally treated with the combination of high doses of sulphadiazine and pyrimethamine. We described two patients with AIDS treated for cerebral toxoplasmosis who developed renal failure due to sulphadiazine-induced crystalluria. Symptoms and renal failure were rapidly reversed with urine al...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1993.tb00685.x
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVES:To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. DESIGN:A case-control study nested within a prospective population study. SUBJECTS:The study cases included 441 men 45-64 years old with n...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.2002.01052.x
更新日期：2002-11-01 00:00:00
abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12945
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Splenectomy is accompanied by a life-long risk of overwhelming postsplenectomy infection (OPSI), mainly caused by polysaccharide (PS) encapsulated bacteria such as Streptococcus pneumoniae. Despite extensive prophylactic efforts the mortality and morbidity rates remain high. The present study was based on a ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2004.01312.x
更新日期：2004-06-01 00:00:00
abstract：:Apart from being an acute phase reactant, fibrinogen appears to play an important although not widely recognized role in athero-/thrombogenesis. Arteriosclerotic diseases are associated with elevated levels of plasma fibrinogen. Strategies that lower the cardiovascular risk also lower fibrinogen levels. Virtually all ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.1990.tb00174.x
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVES:Hip and distal arm fractures are associated with osteoporosis in the postmenopausal female. In diabetic patients, bone mass has been found to be reduced leading to the hypothesis that diabetes is a risk factor for osteoporosis. Whether this has any clinical implication has only been sparsely elucidated. DES...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1994.tb01284.x
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to quantify the inter-relationship between bone mineral density and physical activity, muscle strength, and body mass composition in a group of healthy 16-20-year-old women. DESIGN:A cross-sectional study. SETTING:Reykjavik area. SUBJECTS:Two-hundred and fifty-four Icelandic Caucas...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1999.00486.x
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurre...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/joim.12998
更新日期：2020-03-01 00:00:00
abstract：:During the long history of development of haemoglobin (Hb)-based O2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2007.01893.x
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:To investigate the relationship between cardiac repolarization (QT interval duration) and intima media thickness (IMT) of the carotid arteries as surrogate measures of subclinical atherosclerosis. DESIGN:Prospective study with consecutive subjects enrolled in the SAPHIR program (Salzburg Atherosclerosis Pre...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2004.01436.x
更新日期：2005-03-01 00:00:00
abstract：:The ground-breaking discovery of genotype-phenotype relationships in hereditary medullary thyroid cancer has greatly facilitated early prophylactic thyroidectomy. Its timing depends not solely on a positive gene test but, more importantly, on the type of the REarranged during Transfection (RET) mutation and its underl...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2009.02113.x
更新日期：2009-07-01 00:00:00
abstract：:Helicobacter pylori is one of the most common pathogenic bacterial infections, colonizing an estimated half of all humans. In a subset of individuals, the infection leads to serious gastroduodenal disease such as peptic ulcers and gastric adenocarcinoma. The factors contributing to skewing this, in most cases benign, ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2796.2003.01119.x
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Bile acid (BA) synthesis is essential in cholesterol and lipid homoeostasis. METHODS:Serum samples from 435 normal and 23 cholecystectomized subjects were obtained after overnight fasting and assayed for markers of BA and cholesterol synthesis, as well as cholesterol absorption. We determined whether BA syn...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2011.02466.x
更新日期：2011-12-01 00:00:00
abstract：:The introduction of targeted biological therapies has revolutionised the management of immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. Following treatment with these therapies, many patients experience significant improvement...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12432
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to identify predictors of weight loss in obese men participating in a 2-year behaviour modification programme. DESIGN:Longitudinal, clinical intervention study of a behaviour modifying weight loss program. SETTING:University Hospital, Stockholm, Sweden. SUBJECTS:Forty-four ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.2000.00737.x
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Benefit from endovascular thrombectomy (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) is well demonstrated. Furthermore, emerging evidence supports efficacy in appropriately selected patients treated beyond current recommendations of 6 h. We evaluated clinical outcomes in ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1111/joim.12680
更新日期：2017-12-01 00:00:00
abstract：:Developing new pharmacotherapies for autism spectrum disorder (ASD) is a challenge. ASD has a complex genetic architecture, several neurobiological phenotypes and multiple symptom domains. However, new opportunities are emerging that could lead to the development of 'targeted' and individualized pharmacological interv...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12113
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:The effects of atorvastatin, a new synthetic HMG-CoA reductase inhibitor, were investigated in patients with familial hypercholesterolaemia (FH), with high LDLc levels whilst on standard treatment. DESIGN:Open treatment with 40 mg atorvastatin daily for 6 weeks, followed by another 6 weeks with 80 mg atorva...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2796.1998.00352.x
更新日期：1998-08-01 00:00:00
abstract：:Progress in the testing of therapies targeting the immune response following trauma, a leading cause of morbidity and mortality worldwide, has been slow. We propose that the design of interventional trials in trauma would benefit from a scheme or platform that could support the identification and implementation of pro...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12874
更新日期：2019-07-01 00:00:00
abstract：:The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12610
更新日期：2017-07-01 00:00:00
abstract：:A 61-year-old female patient, treated for hyperthyroidism with thiamazole, developed a severe maturation arrest in the granulocytic lineage and a total agranulocytosis. Subcutaneous GM-CSF was started immediately and given for 6 days. Bone marrow samples were taken before GM-CSF therapy and on days 3 and 8. An increas...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1992.tb00612.x
更新日期：1992-11-01 00:00:00
abstract：:We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.100115000.x
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVES:Few studies have simultaneously analysed the influence of elevated serum uric acid (UA) on acute myocardial infarction (AMI), ischaemic and haemorrhagic stroke (IS, HS) and congestive heart failure (CHF) in large healthy populations. We, here, examine UA as a risk factor for AMI, stroke and CHF by age and ge...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2009.02133.x
更新日期：2009-12-01 00:00:00
abstract：:The association between dental infections and cerebral infarction was investigated in a case-control study involving 40 patients with ischaemic cerebral infarction under the age of 50, and 40 randomly selected community controls matched for sex and age. Poor oral health, as assessed by two indices measuring the severi...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb00060.x
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Atherosclerosis is a multifactorial disease, in part characterized by chronic inflammatory changes in the vessel wall and loss of normal physical and biochemical interactions between endothelial cells and smooth muscle cells. Previous studies [Hu J., Cotgreave IA. J Clin Invest; 99: 1-5] have ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1999.00564.x
更新日期：1999-08-01 00:00:00
abstract：:In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood pressure was in the range 95-120 mmHg were randomly allocated to groups that received either hydrochlorothiazide or metoprolol, or both drugs when the response to one of them was...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2796.1990.tb00240.x
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:The aim of the study was to investigate the association between the proximal level of the clot and the severity of pulmonary embolism (PE). METHODS:The cohort consisted of 99 consecutive patients with PE diagnosed by multi-detector computed tomography. A new score was constructed by calculating the mean val...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2006.01733.x
更新日期：2007-01-01 00:00:00
