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Haematologic effects of granulocyte-macrophage colony stimulating factor in a patient with thiamazole-induced agranulocytosis.

Abstract：

:A 61-year-old female patient, treated for hyperthyroidism with thiamazole, developed a severe maturation arrest in the granulocytic lineage and a total agranulocytosis. Subcutaneous GM-CSF was started immediately and given for 6 days. Bone marrow samples were taken before GM-CSF therapy and on days 3 and 8. An increased number of colonies per 10(5) bone marrow cells documented before institution of GM-CSF treatment was followed by a gradual decline to normal values. An increase of granulocyte count to > 0.5 x 10(9) l-1 was recorded on the 4th day of treatment and was preceded by an increase in the number of immature granulocyte precursors in the bone marrow on day 3. The patient was discharged on day 8 and experienced no adverse effects of GM-CSF treatment. Haematopoietic growth factor therapy has a place in the management of patients with drug induced neutropenia/agranulocytosis, which should be further delineated by prospective studies.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Björkholm M,Pisa P,Arver S,Beran M

doi

10.1111/j.1365-2796.1992.tb00612.x

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

443-5

issue

5

eissn

0954-6820

issn

1365-2796

journal_volume

232

pub_type

杂志文章

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