Abstract:
OBJECTIVE:The aim of the present study was to ascertain the degree of occurrence of tuberculous infection in patients presenting with low back pain (LBP). METHODS:Forty consecutive patients seeking primary medical attention for the main symptom of LBP and presenting to the Rheumatology Outpatient Clinic of our institution from January 2004 to June 2005, were recruited in this cohort study. All patients were thoroughly interrogated (occupational, trauma, infection, diabetes mellitus and medication history), subjected to a rigorous clinical examination and a battery of investigations RESULTS:Twelve of the 40 patients (33%) proved to have spinal TB as the cause of backache. Eight of these patients were above the age of 65. Five of the 12 patients with spinal TB also had concomitant osteoarthritic changes of the spine and two patients had concomitant disc prolapse. Eleven of the 12 patients with spinal TB had a completely normal chest X-ray and in 10 of these patients the plain X-ray of the lumbosacral region failed to show any significant lesion. In all 12 patients, sputum analysis failed to reveal acid-fast bacilli. CONCLUSIONS:The findings of this study indicate that TB is a common cause of LBP that is liable to be overlooked in the differential diagnosis of LBP. Furthermore, evidence of concurrent active intrathoracic TB may be lacking and consequently a high level of suspicion is required. The need for prompt diagnosis and treatment of skeletal TB is of utmost importance to prevent serious bone and joint destruction and severe neurological sequelae. A reliable imaging modality for diagnosing spinal TB seems to be magnetic resonance imaging.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Abou-Raya S,Abou-Raya Adoi
10.1111/j.1365-2796.2006.01675.xsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
160-3issue
2eissn
0954-6820issn
1365-2796pii
JIM1675journal_volume
260pub_type
杂志文章abstract:BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...
journal_title:Journal of internal medicine
pub_type: 杂志文章,meta分析
doi:10.1111/j.1365-2796.2012.02576.x
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abstract::Pulsatile, intravenous insulin infusion designed to mimic the portal insulin concentrations that emerge physiologically after a meal, has been postulated to improve glucose tolerance in Type 1 (insulin-dependent) diabetic patients. We studied the effects of insulin pulsing (10 i.v. pulses of human insulin of 0.035 U k...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1989.tb01403.x
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abstract::As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer st...
journal_title:Journal of internal medicine
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journal_title:Journal of internal medicine
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1989.tb01353.x
更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
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doi:10.1046/j.1365-2796.2000.00737.x
更新日期:2000-10-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1994.tb01031.x
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1111/joim.12096
更新日期:2013-09-01 00:00:00
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doi:10.1111/j.1365-2796.2010.02294.x
更新日期:2011-03-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1046/j.1365-2796.1997.69891000.x
更新日期:1997-01-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
doi:10.1111/joim.13045
更新日期:2020-07-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/joim.13066
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1991.tb00313.x
更新日期:1991-01-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1995.tb01237.x
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1046/j.1365-2796.1998.00286.x
更新日期:1998-03-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1991.tb00312.x
更新日期:1991-01-01 00:00:00
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
abstract::For nearly a decade since the mapping of the multiple endocrine neoplasia type 1 (MEN1) locus to 11q13 and the suggestion that it is a tumour suppressor gene, efforts have been made to identify the gene responsible for this familial cancer syndrome. Recently, we have identified the MEN1 gene by the positional cloning ...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1046/j.1365-2796.1998.00346.x
更新日期:1998-06-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1992.tb00499.x
更新日期:1992-01-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.2011.02368.x
更新日期:2011-09-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1046/j.1365-2796.1997.00196.x
更新日期:1997-10-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1992.tb00599.x
更新日期:1992-10-01 00:00:00