The required beta cell research for improving treatment of type 2 diabetes.

Abstract:

:In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.

journal_name

J Intern Med

authors

Thorens B

doi

10.1111/joim.12096

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

203-14

issue

3

eissn

0954-6820

issn

1365-2796

journal_volume

274

pub_type

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