Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study.


OBJECTIVES:The magnitude of cardiovascular risk associated with psoriasis has been debated and the prognostic impact of psoriasis following myocardial infarction (MI) is unknown. Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients with psoriasis following first-time MI. DESIGN, SETTING AND PARTICIPANTS:Cohort study of the entire Danish population including all individuals who experienced first-time MI during the period 2002-2006. Multivariable Cox regression models were used to assess the post-MI prognostic impact of psoriasis. Main outcome measures.  All-cause mortality and a composite cardiovascular end-point of recurrent MI, stroke and cardiovascular death. RESULTS:A total of 462 patients with psoriasis and 48 935 controls (mean age 69.5 and 70.6 years, respectively) were identified with first-time MI during the study period. The mean follow-up was 19.5 months [standard deviation (SD) 16.5] for patients with psoriasis and 22 .0 months (SD 18.7) for those without psoriasis. Incidence rates (IRs) per 1000 patient-years for all-cause mortality were 119.4 [95% confidence interval (CI) 117.2-138.3] and 138.3 (95% CI 114.1-167.7) for patients without and with psoriasis, respectively, and the adjusted hazard ratio (HR) associated with psoriasis was 1.18 (95% CI 0.97-1.43). For the composite end-point, the IRs were 149.7 (95% CI 147.1-152.4) and 185.6 (95% CI 155.8-221.0) for patients without and with psoriasis, respectively, with an HR of 1.26 (95% CI 1.04-1.54) for patients with psoriasis. CONCLUSION:This first study of the impact of psoriasis on prognosis after first-time MI indicated a significantly impaired prognosis in patients with psoriasis. Further studies of this novel association are warranted.


J Intern Med


Ahlehoff O,Gislason GH,Lindhardsen J,Olesen JB,Charlot M,Skov L,Torp-Pedersen C,Hansen PR




Has Abstract


2011-09-01 00:00:00












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    abstract::The prevalence of coronary heart disease (CHD) was determined in a population survey in Mauritius where the prevalence of non-insulin dependent diabetes and mortality from CHD are amongst the highest in the world. Men and women aged 35-74 years of all major ethnic groups were included: Asian Indians (Hindus and Muslim...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Tuomilehto J,Li N,Dowse G,Gareeboo H,Chitson P,Fareed D,Min Z,Alberti KG,Zimmet P

    更新日期:1993-02-01 00:00:00

  • Studies on patients establish Crohn's disease as a manifestation of impaired innate immunity.

    abstract::The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Segal AW

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  • Blood analyses and survival in symptom- and survey-detected lung cancer patients.

    abstract::Commonly recorded blood analyses as indicators of low- and-high risk patients with lung cancer were studied by comparing symptom- and survey-detected patients. During the period 1976-1985, in 41 of 189 non-small-cell lung cancer patients in Western Norway, lung cancer was detected by chest X-ray survey performed in th...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Hannisdal E,Engan T

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  • Prevalence and extent of subclinical atherosclerosis in patients with psoriasis.

    abstract:OBJECTIVE:Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN:A cross-sectional study. SETTING AND SUBJECTS:The prevalence and extent of coronary and car...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Yiu KH,Yeung CK,Zhao CT,Chan JC,Siu CW,Tam S,Wong CS,Yan GH,Yue WS,Khong PL,Chan HH,Tse HF

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  • Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene.

    abstract::APOA5 encodes a novel apolipoprotein (apo A-V) which appears to be a modulator of plasma triglyceride (TG). In apoA5 knock out mice plasma TG level increases almost fourfold, whereas in human APOA5 transgenic mice it decreases by 70%. Some SNPs in the APOA5 gene have been associated with variations in plasma TG in hum...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Acute effect of multiple ozone metrics on mortality by season in 34 Chinese counties in 2013-2015.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,meta分析,多中心研究


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  • The influence of thrombolytic therapy on the predictive value of exercise testing 3 weeks after acute myocardial infarction.

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  • Hyponatraemia in acute brain disease.

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  • Lipid lowering in severe familial hypercholesterolaemia: efficacy and safety of a new regenerating system for selective apheresis of apolipoprotein B-containing lipoproteins.

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    journal_title:Journal of internal medicine

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  • Chlamydia pneumoniae IgA- and IgG antibodies in young survivors of myocardial infarction. A comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,meta分析,评审


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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


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  • Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma.

    abstract::Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, inc...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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    更新日期:2003-02-01 00:00:00

  • High D-dimer levels increase the likelihood of pulmonary embolism.

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    journal_title:Journal of internal medicine

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  • Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Baldini M,Gallazzi M,Orsatti A,Fossati S,Leonardi P,Cantalamessa L

    更新日期:2002-05-01 00:00:00

  • Impaired incretin effect is an early sign of glucose dysmetabolism in nondiabetic patients with psoriasis.

    abstract:BACKGROUND:Patients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is r...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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    abstract::A 61-year-old female patient, treated for hyperthyroidism with thiamazole, developed a severe maturation arrest in the granulocytic lineage and a total agranulocytosis. Subcutaneous GM-CSF was started immediately and given for 6 days. Bone marrow samples were taken before GM-CSF therapy and on days 3 and 8. An increas...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Prevention of breast cancer in the context of a national breast screening programme.

    abstract::Breast cancer is not only increasing in the west but also particularly rapidly in eastern countries where traditionally the incidence has been low. The rise in incidence is mainly related to changes in reproductive patterns and lifestyle. These trends could potentially be reversed by defining women at greatest risk an...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Howell A,Astley S,Warwick J,Stavrinos P,Sahin S,Ingham S,McBurney H,Eckersley B,Harvie M,Wilson M,Beetles U,Warren R,Hufton A,Sergeant J,Newman W,Buchan I,Cuzick J,Evans DG

    更新日期:2012-04-01 00:00:00

  • Acute renal failure due to carnitine palmitoyltransferase deficiency.

    abstract::A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

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    pub_type: 杂志文章


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  • Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

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    pub_type: 杂志文章


    authors: Lewis I,Pairman J,Spickett G,Newton JL

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  • Unintentional self-intoxication with inorganic calcium.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Cigarette smoking and the risk of goitre and thyroid nodules amongst parous women.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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  • Vitamin D deficiency and frailty in older Americans.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


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    更新日期:2010-08-01 00:00:00