Potential role of insulin in the clearance of remnant lipoproteins in dysbetalipoproteinaemia.

abstract：:Hip fractures in the elderly represent a global issue, associated with significant morbidity and mortality. Considering the magnitude of the problem, any substantial reduction in the hip fracture burden depends on prevention. In view of the complex pathogenesis of senile (type II) osteoporosis, preventive strategies s...

journal_title：Journal of internal medicine

authors： Boonen S,Dequeker J

更新日期：1996-05-01 00:00:00

abstract：:A total of 1280 80-year-old men were invited to a medical examination to study common risk indicators for cardiovascular disease (CVD) in the elderly. From the pool of 811 responders (63.3%), all 122 individuals who fulfilled our inclusion criteria were assigned to one of four groups: (1) no CVD, non-smokers; (2) no C...

journal_title：Journal of internal medicine

authors： Stavenow L,Elmståhl S,Jerntorp P,Nilsson-Ehle P,Pessah-Rasmussen H,Galvard H,Hansen F,Samuelsson SM

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:Obesity has generally been associated with higher bone density and lower fracture risk. However, weight-related indices of obesity may be related differently to health end-points, compared with fat-related indices (such as body fat distribution and fat mass), as they may capture different dimensions of obesi...

journal_title：Journal of internal medicine

authors： Moayyeri A,Luben RN,Wareham NJ,Khaw KT

更新日期：2012-05-01 00:00:00

abstract：:When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

journal_title：Journal of internal medicine

authors： Kaessmann H,Pääbo S

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:To describe types of diabetes treatment in a total, adult population, including those on no antidiabetic medication, and to evaluate use of the defined daily doses in estimation of diabetes prevalence. DESIGN:Cross-sectional epidemiologic survey applying patient-based questionnaires and clinical examination...

journal_title：Journal of internal medicine

authors： Midthjell K,Holmen J,Bjørndal A

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:To analyse whether there is an association between country of birth in first-generation immigrants and first hospitalization for or death from coronary heart disease (CHD) and to analyse whether this association remains in second-generation immigrants. DESIGN:In this follow-up study, the MigMed database at ...

journal_title：Journal of internal medicine

authors： Sundquist K,Li X

更新日期：2006-04-01 00:00:00

abstract：:Inflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti-inflammatory therapies both in clinical and in experimental settings, highlights the important role of brain inflammation...

journal_title：Journal of internal medicine

authors： Maroso M,Balosso S,Ravizza T,Liu J,Bianchi ME,Vezzani A

更新日期：2011-10-01 00:00:00

abstract：:The past few years have witnessed a major breakthrough in the understanding of the molecular mechanisms and ultrastructural changes behind the development of proteinuria. The discovery of several proteins in the glomerular podocyte and slit diaphragm, where mutations lead to disease, has revealed the importance of thi...

journal_title：Journal of internal medicine

authors： Tryggvason K,Pettersson E

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The X-linked Fabry disease (FD) is a multiorgan disorder due to alpha-galactosidase A (α-GAL) deficiency with consequent lysosomal accumulation of globotriaosylceramide (Gb3). We established the immunocytochemical detection of Gb3 in blood cells of FD patients as a new method for FD diagnostics, follow-up an...

journal_title：Journal of internal medicine

authors： Üçeyler N,Böttger J,Henkel L,Langjahr M,Mayer C,Nordbeck P,Wanner C,Sommer C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The original definition of microalbuminuria (20-200 microg min-1 or 15-150 microg min-1 overnight) is based on studies of patients with diabetes, in whom microalbuminuria was associated with increased risk of chronic renal failure. In a recent report an overnight urinary albumin excretion (UAE) above only 5 ...

journal_title：Journal of internal medicine

authors： Klausen KP,Scharling H,Jensen JS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Bupropion sustained release (bupropion SR) has been shown to increase smoking cessation success rates in the US studies. OBJECTIVE:To determine whether bupropion SR, in combination with counselling, is effective for smoking cessation in a multi-country study. METHODS:This randomized, double-blind, placebo-...

journal_title：Journal of internal medicine

authors： Tønnesen P,Tonstad S,Hjalmarson A,Lebargy F,Van Spiegel PI,Hider A,Sweet R,Townsend J

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Cardiac sarcoidosis (CS) without clinically apparent extracardiac disease may escape detection because of the poor sensitivity of endomyocardial biopsy (EMB). We set out to analyse our experience of repeated and imaging-guided biopsies in clinically isolated CS. METHODS:We retrospectively reviewed the medic...

journal_title：Journal of internal medicine

authors： Kandolin R,Lehtonen J,Graner M,Schildt J,Salmenkivi K,Kivistö SM,Kupari M

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke...

journal_title：Journal of internal medicine

authors： Frost L,Johnsen SP,Pedersen L,Toft E,Husted S,Sørensen HT

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of hypertension and other risk factors on mortality, in particular cardiovascular mortality, in a geographically defined population of elderly subjects. DESIGN:An observational 25-year study of a total population. SETTING:The local health centre in the village of Dalby in southern Sw...

journal_title：Journal of internal medicine

authors： Lidfeldt J,Lanke J,Sundquist J,Lindholm LH

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:A low level of education is associated with an increased risk of developing a dementia disorder, as well as with a higher risk of cardiovascular disease. The aim of this study was to investigate the association between education and cardiovascular risk factors, and to study the relation between these factors...

journal_title：Journal of internal medicine

authors： Kilander L,Nyman H,Boberg M,Lithell H

更新日期：1997-10-01 00:00:00

abstract：:The link between inflammation and metabolism was apparent already early last century, but has recently been revitalized following molecular studies of atherosclerosis, obesity and insulin resistance. A growing list of nuclear receptors, pivotal players in lipid, xenobiotic and energy metabolism has been identified as ...

journal_title：Journal of internal medicine

authors： Arulampalam V

更新日期：2008-06-01 00:00:00

abstract：:Clinical symptoms were studied in 69 consecutive patients below the age of 40 years who were attending the emergency unit because of unexplained chest pain. In a structured interview a few weeks after the emergency visit, only one-third of the patients reported that they believed in the doctor's diagnosis; they believ...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology, pathogenesis and clinical features of hepatocellular carcinoma (HCC) in patients with acute intermittent porphyria (AIP). DESIGN:A retrospective population-based mortality study. SUBJECTS:All inhabitants who died between 1978-1990 (2122) including 33 with AIP, in two municipali...

journal_title：Journal of internal medicine

authors： Andersson C,Bjersing L,Lithner F

更新日期：1996-10-01 00:00:00

abstract：:In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hypergl...

journal_title：Journal of internal medicine

authors： Thorens B

更新日期：2013-09-01 00:00:00

abstract：:The objective was to review the current status of meta-analysis, the process of combining the results of similar investigations, which was described in 1976. It has evolved rapidly, and thousands have already been published. Meta-analysis may be performed in a narrative form or in the preferred statistical format, whi...

journal_title：Journal of internal medicine

authors： Conn HO

更新日期：1997-03-01 00:00:00

abstract：:Hypersensitivity to progesterone is rare, but the occurrence of skin rash in the luteal phase of the menstrual cycle or during pregnancy should alert one to this possibility. The diagnosis can be readily confirmed by intradermal testing and is eminently treatable by ovulation suppression. ...

journal_title：Journal of internal medicine

authors： Teelucksingh S,Edwards CR

更新日期：1990-02-01 00:00:00

abstract：:The value of thorough examination of the case history as a diagnostic tool on hospitalization of patients with suspected myocardial infarction was investigated in three independent prospective studies. Use of a limited number of pain-related elements (= 'criteria'), that had already been obtained in the emergency room...

journal_title：Journal of internal medicine

authors： Jonsbu J,Rollag A,Aase O,Lippestad CT,Arnesen KE,Erikssen J,Koss A

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:Waist circumference is a clinical marker of obesity and an established risk factor for cardiovascular (CV) disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, was recently proposed as the missing link between obesity and increased cardiovascular risk. We evaluated waist and adipon...

journal_title：Journal of internal medicine

authors： Holewijn S,den Heijer M,van Tits LJ,Swinkels DW,Stalenhoef AF,de Graaf J

更新日期：2010-06-01 00:00:00

abstract：:Here, the notion of distributive justice is explored in relation to the introduction and the application of new medical technologies within the clinical setting. The point of departure is that, in the decision making process on what is necessary and fair in patient care, participants will mobilize different ethical mo...

journal_title：Journal of internal medicine

authors： van der Kloot Meijburg HH

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:Mixed cryoglobulinaemia (MC) and autoimmune chronic hepatitis (AI-CH) are frequently associated with hepatitis C virus (HCV) chronic infection. Because HCV represents a possible common aetiological factor, the aim of the present study is to investigate the clinico-serological alterations of both MC and AI-CH...

journal_title：Journal of internal medicine

authors： Ferri C,Longombardo G,La Civita L,Greco F,Lombardini F,Cecchetti R,Cagianelli MA,Marchi S,Monti M,Zignego AL

更新日期：1994-07-01 00:00:00

abstract：:A 38-year-old Japanese woman was hospitalized for susceptibility to respiratory tract infections. Clinical examinations revealed asymptomatic primary cholestasis, abnormally elevated immunoglobulin M (IgM) and antimitochondrial antibody, being consistent with asymptomatic primary biliary cirrhosis. Three years later h...

journal_title：Journal of internal medicine

authors： Take H,Kubota K,Tamura K,Kurabayashi H,Tamura J,Shirakura T

更新日期：1995-09-01 00:00:00

abstract：:Hepatitis C virus infection is now one of the most important causes of chronic liver disease. Primary care physicians play an important role in the diagnosis and initial work-up of patients infected with this virus. Understanding which patients may be at risk is the first step. By understanding the correct use of hepa...

journal_title：Journal of internal medicine

authors： Larson AM,Carithers RL

更新日期：2001-02-01 00:00:00

abstract：:In a 24-week randomized multicentre single-blind study, including mild to moderate hypertensives free from other diseases, the effect on blood lipids of captopril (n = 51) was studied and compared with that of metoprolol (n = 53). In order to keep the diastolic pressure less than 95 mm Hg, bendroflumethiazide was adde...

journal_title：Journal of internal medicine

authors： Foss OP,Jensen EK

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVES:Mild hyperhomocysteinaemia (HHC), fasting or after methionine loading, is associated with an increased risk and severity of atherosclerotic vascular disease. Post-methionine and fasting HHC are responsive to treatment with vitamin B, and folic acid. We performed a prospective cohort study amongst normohomocy...

journal_title：Journal of internal medicine

authors： de Jong SC,Stehouwer CD,van den Berg M,Geurts TW,Bouter LM,Rauwerda JA

更新日期：1999-07-01 00:00:00

abstract：:We report on a 43-year-old male patient with Ehlers-Danlos syndrome (EDS) type IV with acute myocardial infarction (MI) without organic coronary stenosis. The disease was complicated with pneumothorax, subcutaneous and mediastinal emphysema, and splenic artery rupture. Three of the patient's family members suffered su...

journal_title：Journal of internal medicine

authors： Nishiyama Y,Nejima J,Watanabe A,Kotani E,Sakai N,Hatamochi A,Shinkai H,Kiuchi K,Tamura K,Shimada T,Takano T,Katayama Y

更新日期：2001-01-01 00:00:00