Very low level of microalbuminuria is associated with increased risk of death in subjects with cardiovascular or cerebrovascular diseases.

abstract：OBJECTIVES:To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia. DESIGN:A prospective study. SETTING:Helsinki University Central Hospital, Finland. SUBJECTS:Seventy-one healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin sen...

journal_title：Journal of internal medicine

authors： Hautanen A,Räikkönen K,Adlercreutz H

更新日期：1997-06-01 00:00:00

abstract：:Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are requ...

journal_title：Journal of internal medicine

authors： Rej A,Aziz I,Sanders DS

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the prognostic value of exercise testing performed soon after acute myocardial infarction (AMI) in patients treated with thrombolytic therapy. DESIGN:A 1-year prospective follow-up of 185 subjects treated with thrombolytic therapy who survived AMI, and who performed exercise testing 3 weeks afte...

journal_title：Journal of internal medicine

authors： Abboud L,Hir J,Eisen I,Markiewicz W

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVES:Angiotensin II may play an important role in the progression of renal disease. Currently, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists are commonly used for renoprotection. To our knowledge, there is no study investigating this effect of angiotensin II receptor antag...

journal_title：Journal of internal medicine

authors： Usta M,Ersoy A,Dilek K,Ozdemir B,Yavuz M,Güllülü M,Yurtkuran M

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to quantify the inter-relationship between bone mineral density and physical activity, muscle strength, and body mass composition in a group of healthy 16-20-year-old women. DESIGN:A cross-sectional study. SETTING:Reykjavik area. SUBJECTS:Two-hundred and fifty-four Icelandic Caucas...

journal_title：Journal of internal medicine

authors： Valdimarsson O,Kristinsson JO,Stefansson SO,Valdimarsson S,Sigurdsson G

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Biomarkers have emerged as interesting predictors of risk in non-ST elevation acute coronary syndromes (non-ST ACS). The aim of this study was to define the utility of the combined measurement of troponin T (TnT), C-reactive protein (CRP), NT pro-brain natriuretic peptide (NT pro-BNP) and D-dimer as biomar...

journal_title：Journal of internal medicine

authors： Tello-Montoliu A,Marín F,Roldán V,Mainar L,López MT,Sogorb F,Vicente V,Lip GY

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:There is currently widespread exposure to the toxic metal cadmium through the diet as well as through smoking, and it has been suggested that cadmium exposure may increase the risk of cardiovascular disease. Here we examined whether cadmium exposure is associated with prevalence and growth of atherosclerotic...

journal_title：Journal of internal medicine

authors： Fagerberg B,Bergström G,Borén J,Barregard L

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：:Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency, and by reducing surgical trauma, several observational studies suggest potentia...

journal_title：Journal of internal medicine

authors： Kastengren M,Svenarud P,Ahlsson A,Dalén M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To develop a method to evaluate routine management practices concerning lipid-lowering treatment in patients with ischaemic heart disease (IHD) in a large geographic area. DESIGN:A register-based study linking information on IHD with cholesterol levels and prescriptions on lipid-lowering medications by perso...

journal_title：Journal of internal medicine

authors： Kanstrup H,Lassen JF,Heickendorff L,Lauritzen T,Larsen ML

更新日期：2004-03-01 00:00:00

abstract：:A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by ...

journal_title：Journal of internal medicine

authors： Habashi HM,Sharp RA,Pippard MJ

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Splenectomy is accompanied by a life-long risk of overwhelming postsplenectomy infection (OPSI), mainly caused by polysaccharide (PS) encapsulated bacteria such as Streptococcus pneumoniae. Despite extensive prophylactic efforts the mortality and morbidity rates remain high. The present study was based on a ...

journal_title：Journal of internal medicine

authors： Landgren O,Björkholm M,Konradsen HB,Söderqvist M,Nilsson B,Gustavsson A,Axdorph U,Kalin M,Grimfors G

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:To examine the occurrence over time of the metabolic syndrome (MetS) according to different definitions and the relation to change during follow-up in carotid artery intima-media thickness (IMT), measured by ultrasound. DESIGN:A cohort of 316, originally 58-year-old men, initially free of diabetes and cardi...

journal_title：Journal of internal medicine

authors： Wallenfeldt K,Hulthe J,Fagerberg B

更新日期：2005-07-01 00:00:00

abstract：:Dysbetalipoproteinaemia is a genetic disorder characterized by accumulation of lipoprotein remnant particles in the plasma, accelerated atherosclerosis, and the abnormal apoprotein E2. Uncontrolled diabetes mellitus can aggravate the hyperlipidaemia associated with this disorder, presumably by increasing triglyceride ...

journal_title：Journal of internal medicine

authors： Duell PB,Bierman EL

更新日期：1991-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of acquired disability globally, and effective treatment methods are scarce. Lately, there has been increasing recognition of the devastating impact of TBI resulting from sports and other recreational activities, ranging from primarily sport-related concussions (SRC) but a...

journal_title：Journal of internal medicine

authors： Marklund N,Bellander BM,Godbolt AK,Levin H,McCrory P,Thelin EP

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. DESIGN:A case-control study nested within a prospective population study. SUBJECTS:The study cases included 441 men 45-64 years old with n...

journal_title：Journal of internal medicine

authors： Reunanen A,Roivainen M,Kleemola M,Saikku P,Leinonen M,Hovi T,Knekt P,Leino A,Aromaa A

更新日期：2002-11-01 00:00:00

abstract：:The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), is rising globally. Dietary lipid over supply leads to lipid accumulation at ectopic sites, such as skeletal muscle. Ectopic lipid storage is highly correlated with insulin resistance and T2D, likely due to a loss of metabolic flex...

journal_title：Journal of internal medicine

authors： Zacharewicz E,Hesselink MKC,Schrauwen P

更新日期：2018-11-01 00:00:00

abstract：:The link between inflammation and metabolism was apparent already early last century, but has recently been revitalized following molecular studies of atherosclerosis, obesity and insulin resistance. A growing list of nuclear receptors, pivotal players in lipid, xenobiotic and energy metabolism has been identified as ...

journal_title：Journal of internal medicine

authors： Arulampalam V

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Mild hyperhomocysteinaemia (HHC), fasting or after methionine loading, is associated with an increased risk and severity of atherosclerotic vascular disease. Post-methionine and fasting HHC are responsive to treatment with vitamin B, and folic acid. We performed a prospective cohort study amongst normohomocy...

journal_title：Journal of internal medicine

authors： de Jong SC,Stehouwer CD,van den Berg M,Geurts TW,Bouter LM,Rauwerda JA

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Polymyalgia rheumatica (PMR) is a rheumatic disease that is characterized by intense activation of systemic inflammation. Systemic inflammation has been associated with an imbalance between endothelial injury and repair, defined by an increased number of circulating endothelial microparticles (EMPs) and a re...

journal_title：Journal of internal medicine

authors： Pirro M,Bocci EB,Di Filippo F,Schillaci G,Mannarino MR,Bagaglia F,Gerli R,Mannarino E

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:The serum levels of the catabolic cytokine TNF-alpha are often raised in malnourished chronic heart failure patients as well as in chronic renal failure (CRF) patients. Angiotensin-converting enzyme (ACE) inhibitors are often used in these patients and may decrease TNF-alpha and IL-1beta levels in vitro and ...

journal_title：Journal of internal medicine

authors： Stenvinkel P,Andersson P,Wang T,Lindholm B,Bergström J,Palmblad J,Heimbürger O,Cederholm T

更新日期：1999-11-01 00:00:00

abstract：:Left ventricular filling pattern was assessed by pulsed Doppler echocardiography at rest and during handgrip exercise in 33 healthy middle-aged subjects. The peak mitral flow-velocities during the early rapid filling phase (E) and during late (atrial) filling (A) were measured and the ratio of these peak flow-velociti...

journal_title：Journal of internal medicine

authors： Airaksinen KE,Ikäheimo MJ,Huikuri HV,Koistinen MJ,Linnaluoto M,Takkunen JT

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVES:To establish a population-based 24-h ambulatory blood pressure (ABP) reference material with day/night mean BP calculated by standardized and true bedtimes. DESIGN:A cross-sectional study of 200 randomly selected subjects (20 men and 20 women in each 10-year age interval 20-70 years) in Linköping, Sweden. ...

journal_title：Journal of internal medicine

authors： Nyström F,Malmström O,Karlberg BE,Ohman KP

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote apoptosis in tumour cells; this could be improved with specific biomarkers of apoptosis for monitoring treatment. We recently observed specific metabolic patterns...

journal_title：Journal of internal medicine

authors： Halama A,Riesen N,Möller G,Hrabě de Angelis M,Adamski J

更新日期：2013-11-01 00:00:00

abstract：:In Sweden, prophylactic treatment of boys with severe haemophilia has been practised since 1958 in an attempt to convert the disease from a severe to a milder form. The present study population consisted of 60 severe haemophiliacs (52 A, 8 B), aged 3-32 years. Treatment is started when the boys are 1-2 years of age, t...

journal_title：Journal of internal medicine

authors： Nilsson IM,Berntorp E,Löfqvist T,Pettersson H

更新日期：1992-07-01 00:00:00

abstract：:Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the followi...

journal_title：Journal of internal medicine

authors： Rosen MR,Cohen IS

更新日期：2006-01-01 00:00:00

abstract：:Patients with established coronary disease and abnormalities of lipid metabolism represent a particularly important subgroup, since their mortality risk is typically 10 times greater than that amongst-subjects with comparable risk factors but no clinical history. Such patients are commonly treated initially with anti-...

journal_title：Journal of internal medicine

authors： Brown BG,Zhao XQ,Bardsley J,Albers JJ

更新日期：1997-04-01 00:00:00

abstract：:When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

journal_title：Journal of internal medicine

authors： Kaessmann H,Pääbo S

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjögren's syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL). OBJECTIVES:To pr...

journal_title：Journal of internal medicine

authors： Baldini C,Santini E,Rossi C,Donati V,Solini A

更新日期：2017-08-01 00:00:00

abstract：:During the period 1974-1983, Yersinia enterocolitica infection was diagnosed in 458 hospitalized patients by antibody response or isolation of the micro-organism. Eight (1.75%) patients showed signs of acute pancreatitis with elevated serum or urine levels of amylase; two patients had acute insulin-dependent diabetes....

journal_title：Journal of internal medicine

authors： Saebø A,Lassen J

更新日期：1992-05-01 00:00:00