Abstract：
:Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are required for the diagnosis of CD, there are no clear biomarkers for the diagnosis of NCGS. The management of both conditions is with a gluten-free diet (GFD), although the duration, as well as strictness of adherence to a GFD in NCGS, is unclear. Adherence to a GFD in CD can also be challenging, with recent developments of noninvasive assessments, although histological assessment via duodenal biopsies remains the gold standard. The management of refractory coeliac disease remains particularly challenging, often requiring specialist input. Whilst wheat is noted to be a trigger for symptom generation in NCGS, it is unclear which components of wheat are responsible for symptom generation in this group, with further research required to elucidate the pathophysiology.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Rej A,Aziz I,Sanders DSdoi
10.1111/joim.13120subject
Has Abstractpub_date
2020-11-01 00:00:00pages
537-549issue
5eissn
0954-6820issn
1365-2796journal_volume
288pub_type
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journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.1992.tb01256.x
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:the aim of this study was to investigate the effects of a healthy Nordic diet (ND) on cardiovascular risk factors. DESIGN AND SUBJECTS:in a randomized controlled trial (NORDIET) conducted in Sweden, 88 mildly hypercholesterolaemic subjects were randomly assigned to an ad libitum ND or control diet (subjects'...
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journal_title：Journal of internal medicine
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doi：10.1046/j.1365-2796.1999.00570.x
更新日期：1999-10-01 00:00:00
abstract：:Developing new pharmacotherapies for autism spectrum disorder (ASD) is a challenge. ASD has a complex genetic architecture, several neurobiological phenotypes and multiple symptom domains. However, new opportunities are emerging that could lead to the development of 'targeted' and individualized pharmacological interv...
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.100115000.x
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:The aims of the study were (i) to examine which antithrombotic therapy patients with known atrial fibrillation use at the point of time when they suffer an ischaemic stroke, (ii) to evaluate the effects of optimal antithrombotic treatment on outcome and severity of the stroke. METHODS:Patients with known at...
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doi：10.1111/j.1365-2796.2005.01512.x
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1992.tb00529.x
更新日期：1992-03-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1993.tb00706.x
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1989-12-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2796.2003.01071.x
更新日期：2003-03-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2010.02237.x
更新日期：2010-07-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.2003.01218.x
更新日期：2003-11-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.2000.00746.x
更新日期：2000-12-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1999.00486.x
更新日期：1999-05-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1990.tb00172.x
更新日期：1990-05-01 00:00:00
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doi：10.1046/j.1365-2796.2000.00567.x
更新日期：2000-01-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1990.tb00252.x
更新日期：1990-10-01 00:00:00
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更新日期：2006-05-01 00:00:00
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更新日期：2001-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb01353.x
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journal_title：Journal of internal medicine
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更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1365-2796.2007.01901.x
更新日期：2008-02-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
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journal_title：Journal of internal medicine
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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更新日期：2007-12-01 00:00:00
