Understanding ageing from an evolutionary perspective.

Abstract:

:There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and repair. Genes controlling the levels of activities, such as DNA repair and antioxidant defence, thus regulate longevity. In addition, there may be contributions either from late-acting deleterious genes that escape the force of natural selection or that trade benefit at an early age against harm at older ages. In some species, there is evidence that genes have evolved to detect and respond to changes in the environment, e.g. food supply. Evolutionary understanding can also help to understand important features of the human life history such as menopause.

journal_name

J Intern Med

authors

Kirkwood TB

doi

10.1111/j.1365-2796.2007.01901.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

117-27

issue

2

eissn

0954-6820

issn

1365-2796

pii

JIM1901

journal_volume

263

pub_type

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