Neutrophil granules in health and disease.

abstract：:Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time betw...

journal_title：Journal of internal medicine

authors： Walker LE,Mirza N,Yip VLM,Marson AG,Pirmohamed M

更新日期：2015-02-01 00:00:00

abstract：:Studies have shown occasional evidence of increased physiological activity in patients with primary insomnia. We hypothesized that metabolic rate, as measured by overall oxygen use (VO2), might be a more general index of increased physiological activity. An initial experiment found elevated VO2 both at night and durin...

journal_title：Journal of internal medicine

authors： Bonnet MH,Arand DL

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:The X-linked Fabry disease (FD) is a multiorgan disorder due to alpha-galactosidase A (α-GAL) deficiency with consequent lysosomal accumulation of globotriaosylceramide (Gb3). We established the immunocytochemical detection of Gb3 in blood cells of FD patients as a new method for FD diagnostics, follow-up an...

journal_title：Journal of internal medicine

authors： Üçeyler N,Böttger J,Henkel L,Langjahr M,Mayer C,Nordbeck P,Wanner C,Sommer C

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia. DESIGN:A prospective study. SETTING:Helsinki University Central Hospital, Finland. SUBJECTS:Seventy-one healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin sen...

journal_title：Journal of internal medicine

authors： Hautanen A,Räikkönen K,Adlercreutz H

更新日期：1997-06-01 00:00:00

abstract：:Pancreatic transplantation was performed in three patients with insulin-dependent diabetes mellitus in whom recurrent and severe episodes of hypoglycaemia had been found to be due to defective glucose counterregulation. Thus in these patients the spontaneous blood glucose recovery after insulin-induced hypoglycaemia (...

journal_title：Journal of internal medicine

authors： Bolinder J,Wahrenberg H,Persson A,Linde B,Tydén G,Groth CG,Ostman J

更新日期：1991-12-01 00:00:00

abstract：:Fifty consecutive patients with confirmed PCP received a high dose of cotrimoxazole for 14 d, or until development of intolerance, directly followed by reduced dose maintenance therapy. Seven individuals died during the high dose course. Twenty (47%) of the 43 survivors showed toxicity reactions that necessitated dose...

journal_title：Journal of internal medicine

authors： Eeftinck Schattenkerk JK,Lange JM,van Steenwijk RP,Danner SA

更新日期：1990-05-01 00:00:00

abstract：:Commonly recorded blood analyses as indicators of low- and-high risk patients with lung cancer were studied by comparing symptom- and survey-detected patients. During the period 1976-1985, in 41 of 189 non-small-cell lung cancer patients in Western Norway, lung cancer was detected by chest X-ray survey performed in th...

journal_title：Journal of internal medicine

authors： Hannisdal E,Engan T

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVES:To determine whether mutations in APOA1 affect levels of high-density lipoprotein (HDL) cholesterol and to predict risk of ischaemic heart disease (IHD) and total mortality in the general population. BACKGROUND:Epidemiologically, risk of IHD is inversely related to HDL cholesterol levels. Mutations in apoli...

journal_title：Journal of internal medicine

authors： Haase CL,Frikke-Schmidt R,Nordestgaard BG,Kateifides AK,Kardassis D,Nielsen LB,Andersen CB,Køber L,Johnsen AH,Grande P,Zannis VI,Tybjaerg-Hansen A

更新日期：2011-08-01 00:00:00

abstract：:Cardiac pheochromocytoma is a rare tumour and may be difficult to localize. We present a 32-year-old male with a cardiac pheochromocytoma that was successfully resected. An initial unenhanced CT did not reveal the tumour. MIBG-scintigraphy indicated the location, but to get full information, a dynamic contrast-enhance...

journal_title：Journal of internal medicine

authors： Jönsson A,Hallengren B,Manhem P,Lilja B,Stavenow L,Ståhl E,Törnquist C

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Findings from animal studies indicate that growth hormone (GH) may stimulate the production of the putative metabolic regulator fibroblast growth factor 21 (FGF21). We investigated whether circulating FGF21 levels are altered in patients with GH deficiency and characterized how levels of this growth factor ar...

journal_title：Journal of internal medicine

authors： Lundberg J,Höybye C,Krusenstjerna-Hafstrøm T,Bina HA,Kharitonenkov A,Angelin B,Rudling M

更新日期：2013-09-01 00:00:00

abstract：:Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'om...

journal_title：Journal of internal medicine

authors： Bergström G,Berglund G,Blomberg A,Brandberg J,Engström G,Engvall J,Eriksson M,de Faire U,Flinck A,Hansson MG,Hedblad B,Hjelmgren O,Janson C,Jernberg T,Johnsson Å,Johansson L,Lind L,Löfdahl CG,Melander O,Östgren CJ,

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:To compare family physicians' reported practice habits on hypertension in Sweden and Minnesota, and to assess to what extent different national guidelines account for differences. DESIGN:Random samples of family physicians were selected for telephone interviews on their practice of hypertension. SETTING:Pr...

journal_title：Journal of internal medicine

authors： Troein M,Arneson T,Råstam L,Pirie PL,Selander S,Luepker RV

更新日期：1995-09-01 00:00:00

abstract：:The case of a patient with acute occlusion of the right renal artery due to an embolus is described. Using transoesophageal echocardiography, the left atrial appendage could be identified as the source of embolism. Twenty hours after the onset of symptoms, the embolus could be successfully dissolved with an intra-arte...

journal_title：Journal of internal medicine

authors： Mügge A,Gulba DC,Frei U,Wagenbreth I,Grote R,Daniel WG,Lichtlen PR

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

journal_title：Journal of internal medicine

authors： Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

更新日期：2013-01-01 00:00:00

abstract：:There is good evidence that both inherited and environmental factors influence the risk of developing asthma. Only recently, large well-designed studies have been undertaken with the power to identify the genetic causes for asthma, and methods developed in parallel with the Human Genome Project, such as gene expressio...

journal_title：Journal of internal medicine

authors： Melén E,Pershagen G

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:We evaluated mortality from cardiovascular disease (CVD), coronary heart disease (CHD) and all causes in relation to use of any hormone therapy (HT) and HT with oestradiol and norethisterone or levonorgestrel. DESIGN:Population-based cohort study. SETTING AND SUBJECTS:Women in three Norwegian counties were...

journal_title：Journal of internal medicine

authors： Graff-Iversen S,Hammar N,Thelle DS,Tonstad S

更新日期：2004-11-01 00:00:00

abstract：:Multimorbidity, the simultaneous presence of multiple health conditions in an individual, is an increasingly common phenomenon globally. The systematic assessment of the quality of care delivered to people with multimorbidity will be key to informing the organization of services for meeting their complex needs. Yet, c...

journal_title：Journal of internal medicine

authors： Valderas JM,Gangannagaripalli J,Nolte E,Boyd CM,Roland M,Sarria-Santamera A,Jones E,Rijken M

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke...

journal_title：Journal of internal medicine

authors： Frost L,Johnsen SP,Pedersen L,Toft E,Husted S,Sørensen HT

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of the common Finnish and Norwegian mutations in the low density lipoprotein (LDL) receptor gene in Swedish patients with familial hypercholesterolaemia (FH), and to start screening for other mutations in these patients. In contrast to the situation in Norway and Finland, where the f...

journal_title：Journal of internal medicine

authors： Lind S,Eriksson M,Rystedt E,Wiklund O,Angelin B,Eggertsen G

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that normoalbuminuric type 1 diabetic patients segregate into groups with normal and elevated ambulatory blood pressure. To evaluate diurnal variation of blood pressure assessed by individual or fixed night-time periods. DESIGN:Cross-sectional study. SETTING:Tertiary referral centre. ...

journal_title：Journal of internal medicine

authors： Hansen KW,Pedersen MM,Christiansen JS,Mogensen CE

更新日期：1993-08-01 00:00:00

abstract：:Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the followi...

journal_title：Journal of internal medicine

authors： Rosen MR,Cohen IS

更新日期：2006-01-01 00:00:00

abstract：:Primary hyperparathyroidism (HPT) has been associated with hypertension, hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. In the present study, plasma ionized calcium (Ca2+) was studied in relation to cardiovascular risk factors in 20 subjects with mild hypertension. Plasma Ca2+ was found to be negatively ...

journal_title：Journal of internal medicine

authors： Lind L,Wengle B,Lithell H,Ljunghall S

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To study the short-term efficacy, tolerability and safety of the treatment with gemfibrozil 600 mg twice daily or placebo in male patients with established atherosclerosis, with a lipid profile matching the 'high triglyceride-low high-density lipoprotein (HDL) cholesterol trait'. DESIGN:Double-blind randomiz...

journal_title：Journal of internal medicine

authors： Knipscheer HC,Nurmohamed MT,Van den Ende A,Plaat B,Pruijs HJ,Mulder WJ,Kastelein JJ

更新日期：1994-10-01 00:00:00

abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...

journal_title：Journal of internal medicine

authors： Segal AW

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The RET proto-oncogene is known to be the susceptibility gene for various disease phenotypes, including multiple endocrine neoplasia type 2 (MEN 2). Recent studies have also suggested an involvement of RET in the development of the mammalian kidney. Although kidney agenesis or dysgenesis has been observed in ...

journal_title：Journal of internal medicine

authors： Loré F,Talidis F,Di Cairano G,Renieri A

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:Biomarkers have emerged as interesting predictors of risk in non-ST elevation acute coronary syndromes (non-ST ACS). The aim of this study was to define the utility of the combined measurement of troponin T (TnT), C-reactive protein (CRP), NT pro-brain natriuretic peptide (NT pro-BNP) and D-dimer as biomar...

journal_title：Journal of internal medicine

authors： Tello-Montoliu A,Marín F,Roldán V,Mainar L,López MT,Sogorb F,Vicente V,Lip GY

更新日期：2007-12-01 00:00:00

abstract：:The current tuberculosis (TB) vaccine bacillus Calmette-Guérin (BCG) fails to protect against adult pulmonary TB. Yet, its capacity to control miliary TB in newborn infants forms the basis for development of novel vaccine candidates. These either exploit genetic modification of BCG to create a viable replacement vacci...

journal_title：Journal of internal medicine

authors： Kaufmann SH

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Hyponatremia is a common feature of acute illness and associated with increased mortality. This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption. OBJECTIVES:To investigate whether the association between hyponatremia and mortality could b...

journal_title：Journal of internal medicine

authors： Eckart A,Hausfater P,Amin D,Amin A,Haubitz S,Bernard M,Baumgartner A,Struja T,Kutz A,Christ-Crain M,Huber A,Mueller B,Schuetz P

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Angiotensin II may play an important role in the progression of renal disease. Currently, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists are commonly used for renoprotection. To our knowledge, there is no study investigating this effect of angiotensin II receptor antag...

journal_title：Journal of internal medicine

authors： Usta M,Ersoy A,Dilek K,Ozdemir B,Yavuz M,Güllülü M,Yurtkuran M

更新日期：2003-03-01 00:00:00

abstract：:Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well-documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase-derived prostaglandins which act to modulate pathologic processes that would normally imp...

journal_title：Journal of internal medicine

authors： Gambaro G,Perazella MA

更新日期：2003-06-01 00:00:00