Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors.

Abstract:

:Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well-documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase-derived prostaglandins which act to modulate pathologic processes that would normally impair various renal functions. The introduction of the selective COX-2 inhibitors raised hope that this class of drugs would reduce injury in both the gastrointestinal tract and the kidneys. Animal and human data, however, suggest that COX-2 synthesized prostaglandins are important in the modulation of renal physiology during adverse conditions. Hence, it appears that these drugs are equal in causing nephrotoxicity as the nonselective COX inhibitors.

journal_name

J Intern Med

authors

Gambaro G,Perazella MA

doi

10.1046/j.1365-2796.2003.01146.x

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

643-52

issue

6

eissn

0954-6820

issn

1365-2796

pii

1146

journal_volume

253

pub_type

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