当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > Intermittent intravenous followed by intermittent oral 1 alpha(OH)D3 treatment of secondary hyperparathyroidism in uraemia.

Intermittent intravenous followed by intermittent oral 1 alpha(OH)D3 treatment of secondary hyperparathyroidism in uraemia.

Abstract：

OBJECTIVES:To examine whether intermittent oral 1 alpha(OH)D3 treatment of patients on haemodialysis with secondary hyperparathyroidism (HPT) was able to maintain the marked suppression of PTH, which previously had been induced by an intermittent intravenous administration of 1 alpha(OH)D3. Simultaneously, the effect of the different routes of administration of 1 alpha(OH)D3 on the circulating levels of N- and C-terminal PTH fragments was measured. DESIGN:An open study of patients on chronic haemodialysis. SETTING:Renal division, Rigshospitalet, Copenhagen, Denmark. SUBJECTS:A total of 26 patients started and five patients completed the total protocol. INTERVENTIONS:The treatment protocol was divided into three parts: (i) 1 alpha(OH)D3 administered intravenously for > 300 days; then (ii) 1 alpha(OH)D3 administered orally for 100 days, followed by (iii) 1 alpha(OH)D3 administered intravenously again for another 100 days. 1 alpha(OH)D3 was given three times a week at the end of each dialysis. MAIN OUTCOME MEASURES:Intact PTH, N- and C-terminal PTH. RESULTS:Intact PTH levels were significantly (P < 0.0001) suppressed by 90.4 +/- 3.3% after 56 days of intermittent intravenous 1 alpha(OH)D3 treatment. This degree of suppression remained stable during the following period of oral treatment and did not change further when intravenous treatment was reinstituted. The circulating levels of intact PTH and N- and C-terminal iPTH were not influenced by the administered route of 1 alpha(OH)D3. CONCLUSIONS:Intravenous 1 alpha(OH)D3 treatment of the secondary HPT in dialysis patients can safely be changed to oral treatment at the time when optimal suppression of PTH has been achieved.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Brandi L,Daugaard H,Egsmose C,Tvedegaard E,Kjaerulff Nielsen P,Olgaard K

doi

10.1046/j.1365-2796.1996.469810000.x

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

353-60

issue

4

eissn

0954-6820

issn

1365-2796

journal_volume

239

pub_type

临床试验,杂志文章

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