Recombinant nematode anticoagulant protein c2 and other inhibitors targeting blood coagulation factor VIIa/tissue factor.

abstract：OBJECTIVES:the results of experimental studies suggest that vitamin D deficiency activates the renin-angiotensin system and predisposes to hypertension. Results of previous epidemiological studies investigating the association between 25-hydroxyvitamin D [25(OH)D] status and hypertension have not been consistent, perha...

journal_title：Journal of internal medicine

authors： Burgaz A,Byberg L,Rautiainen S,Orsini N,Håkansson N,Arnlöv J,Sundström J,Lind L,Melhus H,Michaëlsson K,Wolk A

更新日期：2011-02-01 00:00:00

abstract：:Inflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti-inflammatory therapies both in clinical and in experimental settings, highlights the important role of brain inflammation...

journal_title：Journal of internal medicine

authors： Maroso M,Balosso S,Ravizza T,Liu J,Bianchi ME,Vezzani A

更新日期：2011-10-01 00:00:00

abstract：:Helicobacter pylori is one of the most common pathogenic bacterial infections, colonizing an estimated half of all humans. In a subset of individuals, the infection leads to serious gastroduodenal disease such as peptic ulcers and gastric adenocarcinoma. The factors contributing to skewing this, in most cases benign, ...

journal_title：Journal of internal medicine

authors： Björkholm B,Falk P,Engstrand L,Nyrén O

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients. DESIGN AND SETTING:This double-blind randomised placebo-controlled trial was performed at the dialysis department of...

journal_title：Journal of internal medicine

authors： Diepeveen SH,Verhoeven GW,Van Der Palen J,Dikkeschei LD,Van Tits LJ,Kolsters G,Offerman JJ,Bilo HJ,Stalenhoef AF

更新日期：2005-05-01 00:00:00

abstract：:We present three patients with variant angina pectoris and episodes of cardiac arrest. All of them had typical clinical symptoms, ST-segment changes in electrocardiogram, and coronary artery spasm confirmed by arteriography. They were treated with high doses of calcium antagonists and nitrates. An automatic cardiovert...

journal_title：Journal of internal medicine

authors： Seniuk W,Mularek-Kubzdela T,Grygier M,Grajek S,Cieśliński A

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:Hip and distal arm fractures are associated with osteoporosis in the postmenopausal female. In diabetic patients, bone mass has been found to be reduced leading to the hypothesis that diabetes is a risk factor for osteoporosis. Whether this has any clinical implication has only been sparsely elucidated. DES...

journal_title：Journal of internal medicine

authors： Melchior TM,Sørensen H,Torp-Pedersen C

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVES:We aimed to characterize the clinical experiences of patients in whom heparin-induced thrombocytopenia (HIT) complicated heparin therapy for venous thromboembolism (VTE) and who switched to argatroban. DESIGN:A retrospective analysis of previously reported prospective, multicentre, historical-controlled Arg...

journal_title：Journal of internal medicine

authors： Begelman SM,Hursting MJ,Aghababian RV,McCollum D

更新日期：2005-12-01 00:00:00

abstract：:We describe a 57-year-old male with hypertrophic obstructive cardiomyopathy and occult blood loss. Septal alcohol ablation reduced the left ventricular outflow tract obstruction and eliminated recurrent bleeding. The case resembles Heyde's syndrome, i.e. the association between occult gastrointestinal bleeding and aor...

journal_title：Journal of internal medicine

authors： Riis Hansen P,Hassager C

更新日期：2003-04-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseas...

journal_title：Journal of internal medicine

authors： de Serres F,Blanco I

更新日期：2014-10-01 00:00:00

abstract：:We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI). Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases. Biological data mainly revealed hepatic failure and lactic acidosis. Histological examination of liver biopsies sho...

journal_title：Journal of internal medicine

authors： Bissuel F,Bruneel F,Habersetzer F,Chassard D,Cotte L,Chevallier M,Bernuau J,Lucet JC,Trepo C

更新日期：1994-04-01 00:00:00

abstract：:Orthostatic hypotension (OH) is a relatively common heterogenous and multifactorial disorder, traditionally classified as neurogenic (less common but often more severe) or nonneurogenic (more common, with no direct signs of autonomic nervous system disease). The different clinical variants of orthostatic intolerance i...

journal_title：Journal of internal medicine

authors： Fedorowski A,Melander O

更新日期：2013-04-01 00:00:00

abstract：:Ebola virus disease (EVD) is a zoonotic disease that causes severe haemorrhagic fever, with high fatality rates of up to 90% in humans. Today, there is no effective treatment available. Person-to-person transmission occurs through exposure to blood or body fluids, which can threaten other household members and first-l...

journal_title：Journal of internal medicine

authors： Mirazimi A

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Red blood cell distribution width (RDW), a measure of variation in erythrocyte volume, has been associated with several cardiovascular disorders, but the relationship with atrial fibrillation (AF) remains unclear. We investigated the association between RDW and incidence of first hospitalization due to AF in...

journal_title：Journal of internal medicine

authors： Adamsson Eryd S,Borné Y,Melander O,Persson M,Smith JG,Hedblad B,Engström G

更新日期：2014-01-01 00:00:00

abstract：:Commonly recorded blood analyses as indicators of low- and-high risk patients with lung cancer were studied by comparing symptom- and survey-detected patients. During the period 1976-1985, in 41 of 189 non-small-cell lung cancer patients in Western Norway, lung cancer was detected by chest X-ray survey performed in th...

journal_title：Journal of internal medicine

authors： Hannisdal E,Engan T

更新日期：1991-04-01 00:00:00

abstract：:A 61-year-old female patient, treated for hyperthyroidism with thiamazole, developed a severe maturation arrest in the granulocytic lineage and a total agranulocytosis. Subcutaneous GM-CSF was started immediately and given for 6 days. Bone marrow samples were taken before GM-CSF therapy and on days 3 and 8. An increas...

journal_title：Journal of internal medicine

authors： Björkholm M,Pisa P,Arver S,Beran M

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1...

journal_title：Journal of internal medicine

authors： Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

更新日期：2004-01-01 00:00:00

abstract：:To determine the effect of prednisolone on severe hypercalcaemia in women with metastatic breast cancer, 30 patients with serum ionized calcium above 1.60 mmol l-1 (reference range 1.15-1.35 mmol l-1) entered a randomized trial. Performance status before entry to the trial and survival time after hypercalcaemia were a...

journal_title：Journal of internal medicine

authors： Kristensen B,Ejlertsen B,Holmegaard SN,Krarup-Hansen A,Transbøl I,Mouridsen H

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Addition of assessment of comorbid diseases ('D') and oxygen saturation ('S') to the CRB-65 score has been recommended to improve its accuracy for risk stratification in community-acquired pneumonia (CAP). The aim of this study was to validate the resulting DS-CRB-65 score in a large cohort of patients with ...

journal_title：Journal of internal medicine

authors： Kolditz M,Ewig S,Schütte H,Suttorp N,Welte T,Rohde G,CAPNETZ study group.

更新日期：2015-08-01 00:00:00

abstract：:Although biofilms have been observed early in the history of microbial research, their impact has only recently been fully recognized. Biofilm infections, which contribute to up to 80% of human microbial infections, are associated with common human disorders, such as diabetes mellitus and poor dental hygiene, but also...

journal_title：Journal of internal medicine

authors： Bjarnsholt T,Buhlin K,Dufrêne YF,Gomelsky M,Moroni A,Ramstedt M,Rumbaugh KP,Schulte T,Sun L,Åkerlund B,Römling U

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：:Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, inc...

journal_title：Journal of internal medicine

authors： Wetzler M,Estrov Z,Talpaz M,Markowitz A,Gutterman JU,Kurzrock R

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVES:In this study, we explore the associations of decreased thyroid hormone levels with inflammation, wasting and survival in biochemically euthyroid patients with end-stage renal disease (ESRD). DESIGN:After exclusion of 23 patients with thyroid-stimulating hormone (TSH) values outside the normal range (0.1-4....

journal_title：Journal of internal medicine

authors： Carrero JJ,Qureshi AR,Axelsson J,Yilmaz MI,Rehnmark S,Witt MR,Bárány P,Heimbürger O,Suliman ME,Alvestrand A,Lindholm B,Stenvinkel P

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN:A cross-sectional study. SETTING AND SUBJECTS:The prevalence and extent of coronary and car...

journal_title：Journal of internal medicine

authors： Yiu KH,Yeung CK,Zhao CT,Chan JC,Siu CW,Tam S,Wong CS,Yan GH,Yue WS,Khong PL,Chan HH,Tse HF

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA- and IgG seroprevalence in young survivors of myocardial infarction and matched contro...

journal_title：Journal of internal medicine

authors： Halvorsen DS,Børvik T,Njølstad I,Gutteberg TJ,Vorland LH,Hansen JB

更新日期：2002-02-01 00:00:00

abstract：:The B lymphocyte-associated antigen CD20 is becoming an important immunotherapy target for autoimmune diseases, although its biological function has not been defined. Besides rheumatoid arthritis, growing experience with B cell-depleting therapy indicates that it may be effective in Sjögren's syndrome, dermatomyositis...

journal_title：Journal of internal medicine

authors： Perosa F,Prete M,Racanelli V,Dammacco F

更新日期：2010-03-01 00:00:00

abstract：:Personalized medicine involves the selection of the safest and most effective pharmacological treatment based on the molecular characteristics of the patient. In the case of anticancer drugs, tumour cell alterations can have a great impact on drug activity and, in fact, most biomarkers predicting response originate fr...

journal_title：Journal of internal medicine

authors： Rodríguez-Antona C,Taron M

更新日期：2015-02-01 00:00:00

abstract：:Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaph...

journal_title：Journal of internal medicine

authors： Serini G,Bussolino F,Maione F,Giraudo E

更新日期：2013-02-01 00:00:00

abstract：:Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular smooth muscle cells, but th...

journal_title：Journal of internal medicine

authors： Bankir L,Bichet DG,Morgenthaler NG

更新日期：2017-10-01 00:00:00

abstract：:Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the followi...

journal_title：Journal of internal medicine

authors： Rosen MR,Cohen IS

更新日期：2006-01-01 00:00:00