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Effect of diet intervention on long-term mortality in healthy middle-aged men with combined hyperlipidaemia.

Abstract：

OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1, within the randomized diet and smoking cessation trial of the Oslo study (n = 1232). METHODS:The participants were randomized to a 5-year diet intervention or a control group. The diet consisted of a traditional lipid-lowering diet with emphasis on reduction of saturated fat, total caloric intake and body weight. The groups were initially well balanced with regard to traditional risk factors for mortality. RESULTS:Thirty-three subjects died during the 24-year observation period [17 of cardiovascular disease (CVD) and 12 of cancer]. In the diet intervention group, mortality was 51% lower (RR = 0.49, 95% CI 0.22-0.91, P = 0.022) as compared with the control group. This difference remained significant in a Cox regression analysis after adjusting for age and smoking status (RR = 0.47, 95% CI 0.23-0.96, P = 0.038). CONCLUSION:This study indicates that the investigated 5-year diet intervention significantly reduces late mortality in healthy middle-aged men with combined hyperlipidaemia.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

doi

10.1046/j.0954-6820.2003.01248.x

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

68-73

issue

1

eissn

0954-6820

issn

1365-2796

pii

1248

journal_volume

255

pub_type

临床试验,杂志文章,随机对照试验

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