Assessment of thyroid and adrenal function in patients with familial amyloidotic polyneuropathy.

Abstract:

:This study was performed to evaluate thyroid and adrenal function in patients with familial amyloidotic polyneuropathy. Twenty-four patients without any clinical overt endocrinological dysfunction were studied. None of the patients showed laboratory evidences of hypo- or hyperthyroidism. A short ACTH-stimulation test was performed in 17 of the patients. A low cortisol response to ACTH stimulation, suggesting adrenocortical insufficiency, was found in four (24%) of the patients, and an intermediate response interpreted as suspected hypofunction was found in three (18%) patients. Low serum dehydroepiandrosterone sulphate levels, suggesting adrenal hypofunction, were found in six (25%) of the patients. We believe that the possibility of glucocorticoid insufficiency should always be considered in patients with familial amyloidotic polyneuropathy.

journal_name

J Intern Med

authors

Olofsson BO,Grankvist K,Boman K,Forsberg K,Lafvas I,Lithner F

doi

10.1111/j.1365-2796.1989.tb00091.x

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

337-41

issue

5

eissn

0954-6820

issn

1365-2796

journal_volume

225

pub_type

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