Minimally invasive mitral valve surgery is associated with a low rate of complications.

abstract：:The introduction of targeted biological therapies has revolutionised the management of immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. Following treatment with these therapies, many patients experience significant improvement...

journal_title：Journal of internal medicine

authors： Isaacs JD,Cutolo M,Keystone EC,Park W,Braun J

更新日期：2016-01-01 00:00:00

abstract：:Dysbetalipoproteinaemia is a genetic disorder characterized by accumulation of lipoprotein remnant particles in the plasma, accelerated atherosclerosis, and the abnormal apoprotein E2. Uncontrolled diabetes mellitus can aggravate the hyperlipidaemia associated with this disorder, presumably by increasing triglyceride ...

journal_title：Journal of internal medicine

authors： Duell PB,Bierman EL

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:To clarify the mechanisms by which smoking is associated to toxic and nontoxic goitre and thyroid nodules. DESIGN:Cohort study. SETTING:Sweden. SUBJECTS:A cohort of 874,507 parous women identified through the Medical Birth Registry, with smoking behaviour assessed through self-reported information at the ...

journal_title：Journal of internal medicine

authors： Galanti MR,Granath F,Cnattingius S,Ekbom-Schnell A,Ekbom A

更新日期：2005-09-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX are tendon xanthomas, cataracts and progressive neurological dysfunction. Here, we characterize an adult fem...

journal_title：Journal of internal medicine

authors： Hansson M,Olin M,Floren CH,von Bahr S,van't Hooft F,Meaney S,Eggertsen G,Björkhem I

更新日期：2007-05-01 00:00:00

abstract：:Recent studies have demonstrated that replacement of C-peptide to normal physiological concentrations in insulin-dependent diabetic (IDDM) patients on a short-term basis (1-3 h) results in decreased glomerular hyperfiltration, augmented glucose utilization and improved autonomic nervous function. More prolonged admini...

journal_title：Journal of internal medicine

authors： Wahren J,Johansson BL,Wallberg-Henriksson H,Linde B,Fernqvist-Forbes E,Zierath JR

更新日期：1996-09-01 00:00:00

abstract：:A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

journal_title：Journal of internal medicine

authors： Berkman N,Meirow D,Katzir Z,Bar-On H

更新日期：1993-03-01 00:00:00

abstract：:We observed two patients with hypercholesterolaemia and tendon xanthomas associated with apolipoprotein (apoE-7) E-7, a rare variant of the apoE isoforms. Both suffered from coronary artery disease and had undergone a coronary bypass operation. Their cholesterol levels were 268 and 310 mg dl-1, respectively. Both pati...

journal_title：Journal of internal medicine

authors： Ueyama Y,Nozaki S,Yanagi K,Hiraoka H,Nakagawa T,Sakai N,Jiao S,Yamashita S,Matsuzawa Y

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:To study the impact of the cost of pharmaceuticals on physicians' decisions about drug prescription. DESIGN:A simulation protocol for the treatment of two patients, one with mild and the other with a severe form of urinary tract infection (UTI), was designed. Thirty family physicians in outpatient clinics an...

journal_title：Journal of internal medicine

authors： Hart J,Salman H,Bergman M,Neuman V,Rudniki C,Gilenberg D,Matalon A,Djaldetti M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:Single nucleotide polymorphisms in genes encoding inflammatory molecules may determine genetic profiles associated with increased risk of development and progression of cardiovascular diseases. In this study, we evaluated distribution and reciprocal interaction of a set of functionally important polymorphism...

journal_title：Journal of internal medicine

authors： Flex A,Gaetani E,Angelini F,Sabusco A,Chillà C,Straface G,Biscetti F,Pola P,Castellot JJ Jr,Pola R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:Angiotensin II may play an important role in the progression of renal disease. Currently, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists are commonly used for renoprotection. To our knowledge, there is no study investigating this effect of angiotensin II receptor antag...

journal_title：Journal of internal medicine

authors： Usta M,Ersoy A,Dilek K,Ozdemir B,Yavuz M,Güllülü M,Yurtkuran M

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis causing endothelial dysfunction, an early sign of atherogenesis. Symmetric dimethylarginine (SDMA) does not inhibit NO synthases. Peripheral arterial disease (PAD) is a systemic indication of atherosclerosis. METHOD...

journal_title：Journal of internal medicine

authors： Böger RH,Endres HG,Schwedhelm E,Darius H,Atzler D,Lüneburg N,von Stritzky B,Maas R,Thiem U,Benndorf RA,Diehm C

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:The mortality from coronary heart disease (CHD) is exceptionally low in northernmost Finland, the Sámi (formerly known as Lapp) area. To clarify the reasons for this, the levels of serum cholesterol, other classic risk factors, and major antioxidants, alpha-tocopherol, retinol, albumin and selenium were dete...

journal_title：Journal of internal medicine

authors： Luoma PV,Näyhä S,Sikkilä K,Hassi J

更新日期：1995-01-01 00:00:00

abstract：:We present three patients with variant angina pectoris and episodes of cardiac arrest. All of them had typical clinical symptoms, ST-segment changes in electrocardiogram, and coronary artery spasm confirmed by arteriography. They were treated with high doses of calcium antagonists and nitrates. An automatic cardiovert...

journal_title：Journal of internal medicine

authors： Seniuk W,Mularek-Kubzdela T,Grygier M,Grajek S,Cieśliński A

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein A-V (apoAV) contributes to the regulation of triglyceride metabolism, which plays a role in the pathogenesis of atherosclerotic diseases. We therefore ascertained determinants of hepatic APOA5 transcript and apoAV plasma levels in humans. DESIGN:We determined influences of anthropometric varia...

journal_title：Journal of internal medicine

authors： Hahne P,Krempler F,Schaap FG,Soyal SM,Höffinger H,Miller K,Oberkofler H,Strobl W,Patsch W

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:The bb genotype of the BsmI polymorphism of the vitamin D receptor (VDR) is more common in primary hyperparathyroidism (HPT) than in the general population in Swedish and German women. However, little is known about the association of HPT with the start codon polymorphism of the VDR (defined by FokI). OBJ...

journal_title：Journal of internal medicine

authors： Sosa M,Torres A,Martín N,Salido E,Limiñana JM,Barrios Y,De Miguel E,Betancor P

更新日期：2000-01-01 00:00:00

abstract：:A female patient developed warfarin resistance after 2 years of satisfactory therapy. Only a third of orally administered warfarin was absorbed, the clearance of warfarin was normal. The patient was also resistant for dicoumarol, while phenandione had satisfactory effect on the prothrombin time (PT). ...

journal_title：Journal of internal medicine

authors： Talstad I,Gamst ON

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To evaluate if exercise-induced ST-segment depression without typical angina pectoris is related to increases in sympatho-adrenal activity or beta-adrenoceptor sensitivity. PATIENTS:Thirteen patients (four men) aged 35-62 years with ST-segment depression during exercise but atypical symptoms and normal myoca...

journal_title：Journal of internal medicine

authors： Sundkvist GM,Hjemdahl P,Kahan T,Melcher A

更新日期：2007-02-01 00:00:00

abstract：:The case of a patient with acute occlusion of the right renal artery due to an embolus is described. Using transoesophageal echocardiography, the left atrial appendage could be identified as the source of embolism. Twenty hours after the onset of symptoms, the embolus could be successfully dissolved with an intra-arte...

journal_title：Journal of internal medicine

authors： Mügge A,Gulba DC,Frei U,Wagenbreth I,Grote R,Daniel WG,Lichtlen PR

更新日期：1990-09-01 00:00:00

abstract：:Apart from being an acute phase reactant, fibrinogen appears to play an important although not widely recognized role in athero-/thrombogenesis. Arteriosclerotic diseases are associated with elevated levels of plasma fibrinogen. Strategies that lower the cardiovascular risk also lower fibrinogen levels. Virtually all ...

journal_title：Journal of internal medicine

authors： Ernst E

更新日期：1990-06-01 00:00:00

abstract：:A survey among Danish students revealed that 33 (7.2%) of the respondents had experience with hallucinogenic mushrooms (HM). Afterwards these students answered an extended questionnaire about habits and pattern of consumption. It seems that mushroom use is experimental and may be due to risk-seeking behaviour but is m...

journal_title：Journal of internal medicine

authors： Lassen JF,Lassen NF,Skov J

更新日期：1993-02-01 00:00:00

abstract：:The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), is rising globally. Dietary lipid over supply leads to lipid accumulation at ectopic sites, such as skeletal muscle. Ectopic lipid storage is highly correlated with insulin resistance and T2D, likely due to a loss of metabolic flex...

journal_title：Journal of internal medicine

authors： Zacharewicz E,Hesselink MKC,Schrauwen P

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

journal_title：Journal of internal medicine

authors： Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

更新日期：2013-01-01 00:00:00

abstract：:The onset of human disease by infection with SARS-CoV-2 causing COVID-19 has revealed risk factors for disease severity. There are four identified factors that puts one at high-risk for infection and/or mortality creating a disparity: age, comorbidities, race/ethnicity, and gender. Data indicate that the older a perso...

journal_title：Journal of internal medicine

authors： Carethers JM

更新日期：2020-11-08 00:00:00

abstract：:The association of sex, age, relative weight, smoking and drinking habits, chronic obstructive pulmonary disease (COPD) and economic and marital status, with benign oesophageal disease (BOD) was investigated by means of a point-prevalence study of BOD in a Danish population. A total of 346 individuals, representing su...

journal_title：Journal of internal medicine

authors： Andersen LI,Jensen G

更新日期：1991-07-01 00:00:00

abstract：:Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in th...

journal_title：Journal of internal medicine

authors： Capitini CM,Chisti AA,Mackall CL

更新日期：2009-08-01 00:00:00

abstract：:The hypothesis that asymptomatic visual field defects can be found in patients with carotid transient ischaemic attacks (TIA) or minor strokes was tested. Twenty-two consecutive male patients with TIA and 18 patients with minor strokes from the carotid artery territory were examined by perimetry, cerebral computerised...

journal_title：Journal of internal medicine

authors： Falke P,Abela BM Jr,Krakau CE,Lilja B,Lindgärde F,Maly P,Stavenow L

更新日期：1991-06-01 00:00:00

abstract：:The B lymphocyte-associated antigen CD20 is becoming an important immunotherapy target for autoimmune diseases, although its biological function has not been defined. Besides rheumatoid arthritis, growing experience with B cell-depleting therapy indicates that it may be effective in Sjögren's syndrome, dermatomyositis...

journal_title：Journal of internal medicine

authors： Perosa F,Prete M,Racanelli V,Dammacco F

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:The cell cycle regulator cyclin D1 plays an important role in parathyroid tumourigenesis. The NciI polymorphism in exon 4 has recently been associated with early onset of hereditary nonpolyposis colorectal cancer and is a prognostic indicator of nonsmall cell lung cancer and squamous cell carcinomas. Further...

journal_title：Journal of internal medicine

authors： Correa P,Lundgren E,Rastad J,Akerström G,Westin G,Carling T

更新日期：2001-12-01 00:00:00

abstract：:To determine the effect of prednisolone on severe hypercalcaemia in women with metastatic breast cancer, 30 patients with serum ionized calcium above 1.60 mmol l-1 (reference range 1.15-1.35 mmol l-1) entered a randomized trial. Performance status before entry to the trial and survival time after hypercalcaemia were a...

journal_title：Journal of internal medicine

authors： Kristensen B,Ejlertsen B,Holmegaard SN,Krarup-Hansen A,Transbøl I,Mouridsen H

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The original definition of microalbuminuria (20-200 microg min-1 or 15-150 microg min-1 overnight) is based on studies of patients with diabetes, in whom microalbuminuria was associated with increased risk of chronic renal failure. In a recent report an overnight urinary albumin excretion (UAE) above only 5 ...

journal_title：Journal of internal medicine

authors： Klausen KP,Scharling H,Jensen JS

更新日期：2006-09-01 00:00:00