Do drug costs affect physicians' prescription decisions?

abstract：OBJECTIVES:Atherosclerosis is an inflammatory disease of the arterial wall that leads to myocardial infarction and stroke. Regulatory T cells (Tregs) and IL-10 exert significant anti-atherogenic effects in experimental models of atherosclerosis by modulating vascular inflammation. We have previously shown that Mycobact...

journal_title：Journal of internal medicine

authors： Ovchinnikova OA,Berge N,Kang C,Urien C,Ketelhuth DF,Pottier J,Drouet L,Hansson GK,Marchal G,Bäck M,Schwartz-Cornil I,Lagranderie M

更新日期：2014-01-01 00:00:00

abstract：:Rare cases of hepatotoxicity have been attributed to the antiarrhythmic agent procainamide. We here describe the case of a patient who had a hypersensitivity reaction to procainamide with fever, chills, arthralgia, abdominal pain and acute elevations of serum aminotransferase activities and bilirubin concentration. Th...

journal_title：Journal of internal medicine

authors： Worman HJ,Ip JH,Winters SL,Tepper DC,Gomes AJ

更新日期：1992-10-01 00:00:00

abstract：:Six patients with acute renal failure, in five cases due to acute crescentic glomerulonephritis and in one case due to total bilateral renal cortical necrosis, were studied. All had serum erythropoietin (EPO) concentrations in the normal range, despite a relatively severe anaemia. Half-life and plasma clearance of int...

journal_title：Journal of internal medicine

authors： Thaysen JH,Nielsen OJ,Brandi L,Szpirt W

更新日期：1991-04-01 00:00:00

abstract：:Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health concerns. Available anti-obesity treatments include weight loss pharmacotherapies and bariatric surgery. Whilst surgical interventions typically result in significant and sustained weight loss, available pharmacotherapies are far les...

journal_title：Journal of internal medicine

authors： Brandt SJ,Müller TD,DiMarchi RD,Tschöp MH,Stemmer K

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women. DESIGN:The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February. SETTING:The municip...

journal_title：Journal of internal medicine

authors： Leppert J,Ringqvist A,Ahlner J,Myrdal U,Sørensen S,Ringqvist I

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1...

journal_title：Journal of internal medicine

authors： Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Patients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is r...

journal_title：Journal of internal medicine

authors： Gyldenløve M,Vilsbøll T,Zachariae C,Holst JJ,Knop FK,Skov L

更新日期：2015-12-01 00:00:00

abstract：:A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

journal_title：Journal of internal medicine

authors： Berkman N,Meirow D,Katzir Z,Bar-On H

更新日期：1993-03-01 00:00:00

abstract：INTRODUCTION:Chronic kidney disease (CKD) predisposes to a 10- to 20-fold increased cardiovascular risk. Patients undergo accelerated atherogenesis and vascular ageing. We investigated whether telomere attrition, a marker of cell senescence, contributes to this increased mortality risk. METHODS:This is a cross-section...

journal_title：Journal of internal medicine

authors： Carrero JJ,Stenvinkel P,Fellström B,Qureshi AR,Lamb K,Heimbürger O,Bárány P,Radhakrishnan K,Lindholm B,Soveri I,Nordfors L,Shiels PG

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Although numerous multicentre studies have estimated the association between ozone exposure and mortality, there are currently no nationally representative multicentre studies of the ozone-mortality relationship in China. OBJECTIVE:To investigate the effect on total (nonaccidental) and cause-specific mortal...

journal_title：Journal of internal medicine

authors： Sun Q,Wang W,Chen C,Ban J,Xu D,Zhu P,He MZ,Li T

更新日期：2018-05-01 00:00:00

abstract：:Previous studies in patients with peripheral arterial disease (PAD) have shown that the prognosis is relatively good when the distal systolic ankle index (ankle systolic pressure/arm systolic pressure) is above 50% and the distal toe systolic pressure is above 40 mmHg. In 132 patients suspected of PAD in the legs we i...

journal_title：Journal of internal medicine

authors： Christensen JH,Freundlich M,Jacobsen BA,Falstie-Jensen N

更新日期：1989-08-01 00:00:00

abstract：:Fifty consecutive patients with confirmed PCP received a high dose of cotrimoxazole for 14 d, or until development of intolerance, directly followed by reduced dose maintenance therapy. Seven individuals died during the high dose course. Twenty (47%) of the 43 survivors showed toxicity reactions that necessitated dose...

journal_title：Journal of internal medicine

authors： Eeftinck Schattenkerk JK,Lange JM,van Steenwijk RP,Danner SA

更新日期：1990-05-01 00:00:00

abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...

journal_title：Journal of internal medicine

authors： Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:We evaluated mortality from cardiovascular disease (CVD), coronary heart disease (CHD) and all causes in relation to use of any hormone therapy (HT) and HT with oestradiol and norethisterone or levonorgestrel. DESIGN:Population-based cohort study. SETTING AND SUBJECTS:Women in three Norwegian counties were...

journal_title：Journal of internal medicine

authors： Graff-Iversen S,Hammar N,Thelle DS,Tonstad S

更新日期：2004-11-01 00:00:00

abstract：:A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by ...

journal_title：Journal of internal medicine

authors： Habashi HM,Sharp RA,Pippard MJ

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed. OBJECTIVES:To clarify risk factors associated with bradykinin-mediated AE after thrombolysis for acute ischemic stroke. METHODS:In a case-contr...

journal_title：Journal of internal medicine

authors： Vigneron C,Lécluse A,Ronzière T,Bouillet L,Boccon-Gibod I,Gayet S,Doche E,Smadja D,Di Legge S,Dumont F,Gaudron M,Ion I,Marcel S,Sévin M,Vlaicu MB,Launay D,Arnaud I,Girard-Madoux P,Héroum C,Lefèvre S,Marc G,Obadi

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated t...

journal_title：Journal of internal medicine

authors： Abbenhardt C,McTiernan A,Alfano CM,Wener MH,Campbell KL,Duggan C,Foster-Schubert KE,Kong A,Toriola AT,Potter JD,Mason C,Xiao L,Blackburn GL,Bain C,Ulrich CM

更新日期：2013-08-01 00:00:00

abstract：:During a 10-year period 39 patients with acromegaly, aged 23-73 years, underwent selective adenomectomy via a trans-sphenoidal or transfrontal (one case) approach. Six to 12 months after the operation, the serum level of growth hormone (GH) was reduced to less than 5 micrograms l-1 in 28 patients (74%) in at least two...

journal_title：Journal of internal medicine

authors： Valdemarsson S,Bramnert M,Cronquist S,Elner A,Eneroth CM,Hedner P,Lindvall-Axelsson M,Nordström CH,Strömblad LG

更新日期：1991-07-01 00:00:00

abstract：INTRODUCTION:Biomarkers have emerged as interesting predictors of risk in non-ST elevation acute coronary syndromes (non-ST ACS). The aim of this study was to define the utility of the combined measurement of troponin T (TnT), C-reactive protein (CRP), NT pro-brain natriuretic peptide (NT pro-BNP) and D-dimer as biomar...

journal_title：Journal of internal medicine

authors： Tello-Montoliu A,Marín F,Roldán V,Mainar L,López MT,Sogorb F,Vicente V,Lip GY

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:As reported by major clinical series in the literature, about 2% of patients receiving unfractionated heparin (UFH) develop immune-mediated (type II) heparin-induced thrombocytopenia (HIT) that may be complicated in 30-75% of cases by a paradoxical thrombotic syndrome (HITTS), either arterial or venous. HITT...

journal_title：Journal of internal medicine

authors： Fabris F,Luzzatto G,Soini B,Ramon R,Scandellari R,Randi ML,Girolami A

更新日期：2002-08-01 00:00:00

abstract：:In order to study the influence of fish oil on CyA-induced renal dysfunction, 13 patients with psoriasis (CyA group) received cyclosporin A (CyA) alone, and seven patients (CyA/EPA + DHA group) received a combination of cyclosporin A and fish oil (6g eicosapentaenoic acid, C20:5 omega-3, and docosahexaenoic acid, C22:...

journal_title：Journal of internal medicine

authors： Stoof TJ,Korstanje MJ,Bilo HJ,Starink TM,Hulsmans RF,Donker AJ

更新日期：1989-12-01 00:00:00

abstract：:The introduction of biologic therapies heralded a new era in the treatment for chronic inflammatory autoimmune diseases of which rheumatoid arthritis is one of the most prevalent. From a scientific point of view, these therapies demonstrated that the targeting of individual cytokines or cell-surface markers is a very ...

journal_title：Journal of internal medicine

authors： Chatzidionysiou K,van Vollenhoven RF

更新日期：2011-06-01 00:00:00

abstract：:The onset of human disease by infection with SARS-CoV-2 causing COVID-19 has revealed risk factors for disease severity. There are four identified factors that puts one at high-risk for infection and/or mortality creating a disparity: age, comorbidities, race/ethnicity, and gender. Data indicate that the older a perso...

journal_title：Journal of internal medicine

authors： Carethers JM

更新日期：2020-11-08 00:00:00

abstract：:Two hundred consecutive patients with femoral neck fractures (FNF) and 200 controls matched by age, sex, nursing home residency and number of admissions within the last 2 years, were interviewed about recent drug use. The matching criteria were chosen to achieve case and control groups that were comparable with regard...

journal_title：Journal of internal medicine

authors： Jensen J,Nielsen LH,Lyhne N,Hallas J,Brøsen K,Gram LF

更新日期：1991-01-01 00:00:00

abstract：:Two cases of young healthy males presenting with cardiac tamponade and developing clinical adrenal insufficiency within a few weeks are described. On presentation they had a brisk inflammatory response with complement activation. Both had signs of subclinical hepatitis, and both have later shown evidence of thyroid in...

journal_title：Journal of internal medicine

authors： Torfoss D,von de Lippe E,Jacobsen D

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:To assess the clinical course of renal function in relation to risk factors in NIDDM patients with normo- and microalbuminuria. DESIGN:Prospective clinical study. SETTING:Outpatient diabetic clinic. SUBJECTS:Thirty-two NIDDM patients with normo- or microalbuminuria followed for (mean (range)) 5.5 (3.3-7.5...

journal_title：Journal of internal medicine

authors： Nielsen S,Schmitz A,Rehling M,Mogensen CE

更新日期：1997-02-01 00:00:00

abstract：:We observed two patients with hypercholesterolaemia and tendon xanthomas associated with apolipoprotein (apoE-7) E-7, a rare variant of the apoE isoforms. Both suffered from coronary artery disease and had undergone a coronary bypass operation. Their cholesterol levels were 268 and 310 mg dl-1, respectively. Both pati...

journal_title：Journal of internal medicine

authors： Ueyama Y,Nozaki S,Yanagi K,Hiraoka H,Nakagawa T,Sakai N,Jiao S,Yamashita S,Matsuzawa Y

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein A-V (apoAV) contributes to the regulation of triglyceride metabolism, which plays a role in the pathogenesis of atherosclerotic diseases. We therefore ascertained determinants of hepatic APOA5 transcript and apoAV plasma levels in humans. DESIGN:We determined influences of anthropometric varia...

journal_title：Journal of internal medicine

authors： Hahne P,Krempler F,Schaap FG,Soyal SM,Höffinger H,Miller K,Oberkofler H,Strobl W,Patsch W

更新日期：2008-11-01 00:00:00