Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study.

abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...

journal_title：Journal of internal medicine

authors： Segal AW

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at...

journal_title：Journal of internal medicine

authors： Fossum E,Gleim GW,Kjeldsen SE,Kizer JR,Julius S,Devereux RB,Brady WE,Hille DA,Lyle PA,Dahlöf B

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote apoptosis in tumour cells; this could be improved with specific biomarkers of apoptosis for monitoring treatment. We recently observed specific metabolic patterns...

journal_title：Journal of internal medicine

authors： Halama A,Riesen N,Möller G,Hrabě de Angelis M,Adamski J

更新日期：2013-11-01 00:00:00

abstract：:Cerebral toxoplasmosis is optimally treated with the combination of high doses of sulphadiazine and pyrimethamine. We described two patients with AIDS treated for cerebral toxoplasmosis who developed renal failure due to sulphadiazine-induced crystalluria. Symptoms and renal failure were rapidly reversed with urine al...

journal_title：Journal of internal medicine

authors： Fariñas MC,Echevarría S,Sampedro I,González A,Pérez del Molino A,González-Macías J

更新日期：1993-04-01 00:00:00

abstract：:In the mitochondrion, inherited defects have been identified in the electron transport system by which ATP is formed, as well as in the transport and metabolism of fuels. Clinical findings in diseases due to these defects can be related to abnormal accumulations of metabolic intermediates and inadequate or inefficient...

journal_title：Journal of internal medicine

authors： Luft R,Landau BR

更新日期：1995-11-01 00:00:00

abstract：:Autoantibodies against three different postsynaptic antigens and one presynaptic antigen at the neuromuscular junction are known to cause myasthenic syndromes. The mechanisms by which these antibodies cause muscle weakness vary from antigenic modulation and complement-mediated membrane damage to inhibition of endogeno...

journal_title：Journal of internal medicine

authors： Huijbers MG,Lipka AF,Plomp JJ,Niks EH,van der Maarel SM,Verschuuren JJ

更新日期：2014-01-01 00:00:00

abstract：:Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disorder characterized by periodic attacks of fever and inflammation, due to mutations in the gene coding for the TNF type I receptor (TNFRSF1A). A 16-year-old patient with the diagnosis of TRAPS was admitted to hospital ...

journal_title：Journal of internal medicine

authors： Stjernberg-Salmela S,Kivisaari A,Puolakkainen P,Färkkilä M,Kemppainen E,Ranki A,Pettersson T

更新日期：2006-02-01 00:00:00

abstract：:Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time betw...

journal_title：Journal of internal medicine

authors： Walker LE,Mirza N,Yip VLM,Marson AG,Pirmohamed M

更新日期：2015-02-01 00:00:00

abstract：:The effects of resuscitation on patients who died suddenly out of hospital were evaluated after the introduction of early defibrillation performed by ambulance personnel using semi-automatic defibrillators. Resuscitation attempts were initiated in 548 patients during the 1-year study period. Mean ambulance delay was 7...

journal_title：Journal of internal medicine

authors： Jakobsson J,Rehnqvist N,Nyquist O

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to ascertain the degree of occurrence of tuberculous infection in patients presenting with low back pain (LBP). METHODS:Forty consecutive patients seeking primary medical attention for the main symptom of LBP and presenting to the Rheumatology Outpatient Clinic of our institu...

journal_title：Journal of internal medicine

authors： Abou-Raya S,Abou-Raya A

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:The RET proto-oncogene is known to be the susceptibility gene for various disease phenotypes, including multiple endocrine neoplasia type 2 (MEN 2). Recent studies have also suggested an involvement of RET in the development of the mammalian kidney. Although kidney agenesis or dysgenesis has been observed in ...

journal_title：Journal of internal medicine

authors： Loré F,Talidis F,Di Cairano G,Renieri A

更新日期：2001-07-01 00:00:00

abstract：:Calcium is important for bone health. It has been customary to focus on dietary calcium intake, but of central importance for the body needs in the individual patient is the actual calcium absorption. This absorption consists of an active vitamin D-mediated component and a passive diffusional component. A number of di...

journal_title：Journal of internal medicine

authors： Charles P

更新日期：1992-02-01 00:00:00

abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

journal_title：Journal of internal medicine

authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

更新日期：2014-02-01 00:00:00

abstract：:As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer st...

journal_title：Journal of internal medicine

authors： Sutlu T,Alici E

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

journal_title：Journal of internal medicine

authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The contribution of plasma lipids to cardiovascular risk is usually evaluated by measuring plasma concentrations of total cholesterol, triglycerides and HDL cholesterol, and calculating LDL cholesterol concentration. We investigated plasma concentrations of apolipoproteins and lipoprotein particles in women ...

journal_title：Journal of internal medicine

authors： Nielsen NE,Olsson AG,Swahn E

更新日期：2000-01-01 00:00:00

abstract：:The International RET Mutation Consortium was first convened as part of the Fifth International Workshop on Multiple Endocrine Neoplasia, Stockholm, Sweden, in an attempt to analyse the relationship of RET mutation and disease phenotype in the autosomal dominantly inherited multiple endocrine neoplasia type 2 (MEN 2) ...

journal_title：Journal of internal medicine

authors： Mulligan LM,Marsh DJ,Robinson BG,Schuffenecker I,Zedenius J,Lips CJ,Gagel RF,Takai SI,Noll WW,Fink M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient's basal...

journal_title：Journal of internal medicine

authors： Recalde-Zamacona B,Tomás-Velázquez A,Campo A,Satrústegui-Alzugaray B,Fernández-Alonso M,Iñigo M,Rodríguez-Mateos M,Di Frisco M,Felgueroso C,Bertó J,Marín-Oto M,Alcaide AB,Zulueta JJ,Seijo L,Landecho MF

更新日期：2020-12-29 00:00:00

abstract：OBJECTIVES:Single nucleotide polymorphisms in genes encoding inflammatory molecules may determine genetic profiles associated with increased risk of development and progression of cardiovascular diseases. In this study, we evaluated distribution and reciprocal interaction of a set of functionally important polymorphism...

journal_title：Journal of internal medicine

authors： Flex A,Gaetani E,Angelini F,Sabusco A,Chillà C,Straface G,Biscetti F,Pola P,Castellot JJ Jr,Pola R

更新日期：2007-07-01 00:00:00

abstract：:Poikilothermia syndrome is a rare cause of intrinsic thermoregulatory failure. Patients with this syndrome regulate body temperature poorly, if at all. Recently, a patient was referred to us who had clinical evidence of poikilothermia syndrome, as well as long-standing multiple sclerosis. Computerized tomography and m...

journal_title：Journal of internal medicine

authors： Kurz A,Sessler DI,Tayefeh F,Goldberger R

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. DESIGN:A case-control study nested within a prospective population study. SUBJECTS:The study cases included 441 men 45-64 years old with n...

journal_title：Journal of internal medicine

authors： Reunanen A,Roivainen M,Kleemola M,Saikku P,Leinonen M,Hovi T,Knekt P,Leino A,Aromaa A

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke...

journal_title：Journal of internal medicine

authors： Frost L,Johnsen SP,Pedersen L,Toft E,Husted S,Sørensen HT

更新日期：2002-07-01 00:00:00

abstract：:Hypertriglyceridaemia, as defined by fasting triglyceride levels of greater than 2.8 mmol l-1, is a prevalent dyslipoproteinaemia in our population. The underlying pathophysiological mechanisms that result in elevations of plasma triglycerides are heterogeneous and, in most cases, incompletely understood. However, in ...

journal_title：Journal of internal medicine

authors： Fojo SS,Brewer HB

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVES:The effect of a second and third generation oral contraceptive and of the progestagens used in these pills on lipid metabolism was studied in the absence or presence of the factor V Leiden mutation. DESIGN:A single centre, double blind randomized trial. SETTING:University Medical Centre. SUBJECTS:A total ...

journal_title：Journal of internal medicine

authors： Kemmeren JM,Algra A,Grobbee DE

更新日期：2001-11-01 00:00:00

abstract：:We describe a 57-year-old male with hypertrophic obstructive cardiomyopathy and occult blood loss. Septal alcohol ablation reduced the left ventricular outflow tract obstruction and eliminated recurrent bleeding. The case resembles Heyde's syndrome, i.e. the association between occult gastrointestinal bleeding and aor...

journal_title：Journal of internal medicine

authors： Riis Hansen P,Hassager C

更新日期：2003-04-01 00:00:00

abstract：:Clinical symptoms were studied in 69 consecutive patients below the age of 40 years who were attending the emergency unit because of unexplained chest pain. In a structured interview a few weeks after the emergency visit, only one-third of the patients reported that they believed in the doctor's diagnosis; they believ...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1991-09-01 00:00:00

abstract：:Cytokine production is necessary to protect against pathogens and promote tissue repair, but excessive cytokine release can lead to systemic inflammation, organ failure and death. Inflammatory responses are finely regulated to effectively guard from noxious stimuli. The central nervous system interacts dynamically wit...

journal_title：Journal of internal medicine

authors： Rosas-Ballina M,Tracey KJ

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The X-linked Fabry disease (FD) is a multiorgan disorder due to alpha-galactosidase A (α-GAL) deficiency with consequent lysosomal accumulation of globotriaosylceramide (Gb3). We established the immunocytochemical detection of Gb3 in blood cells of FD patients as a new method for FD diagnostics, follow-up an...

journal_title：Journal of internal medicine

authors： Üçeyler N,Böttger J,Henkel L,Langjahr M,Mayer C,Nordbeck P,Wanner C,Sommer C

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To investigate the risk of ipsilateral versus contralateral recurrent deep vein thrombosis in the leg. DESIGN:An open prospective long term follow-up multicentre trial. Patients were followed by frequent outpatient visits at each centre during the first 12 months after inclusion and thereafter annually. SE...

journal_title：Journal of internal medicine

authors： Lindmarker P,Schulman S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Patients with venous thromboembolism (VTE) secondary to transient risk factors may develop VTE recurrences after discontinuing anticoagulation. Identifying at-risk patients could help to guide the duration of therapy. METHODS:We used the RIETE database to assess the prognostic value of d-dimer testing after...

journal_title：Journal of internal medicine

authors： Avnery O,Martin M,Bura-Riviere A,Barillari G,Mazzolai L,Mahé I,Marchena PJ,Verhamme P,Monreal M,Ellis MH,RIETE Investigators.

更新日期：2020-01-01 00:00:00