Enterovirus, mycoplasma and other infections as predictors for myocardial infarction.

abstract：OBJECTIVE:Apolipoprotein A-V (apoAV) contributes to the regulation of triglyceride metabolism, which plays a role in the pathogenesis of atherosclerotic diseases. We therefore ascertained determinants of hepatic APOA5 transcript and apoAV plasma levels in humans. DESIGN:We determined influences of anthropometric varia...

journal_title：Journal of internal medicine

authors： Hahne P,Krempler F,Schaap FG,Soyal SM,Höffinger H,Miller K,Oberkofler H,Strobl W,Patsch W

更新日期：2008-11-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by accumulation of oxidized lipoproteins, increased cell death and hypertrophic degeneration of the arterial intima. The disease process is associated with local formation of modified self antigens that are targeted by both innate and adaptive immune resp...

journal_title：Journal of internal medicine

authors： Nilsson J,Hansson GK

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Structural remodelling of left ventricle is a common feature in the progression of congestive heart failure (CHF). Matrix metalloproteinases (MMPs) have been directly implicated as they degrade extracellular proteins. To test the hypothesis that MMP-and its inhibitor, tissue type inhibitor of matrix metallop...

journal_title：Journal of internal medicine

authors： Jordán A,Roldán V,García M,Monmeneu J,de Burgos FG,Lip GY,Marín F

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Plasma fibrinogen predicts cardiovascular events in patients with stable peripheral arterial occlusive disease, but its predictive value in patients with chronic critical limb ischaemia, a condition associated with a high risk of death, is unknown. DESIGN:A prospective cohort study. SETTING:Determination of...

journal_title：Journal of internal medicine

authors： Pedrinelli R,Dell' Omo G,Barchielli A,Berchiolli R,Melillo E,Mariani M,Balbarini A,Ferrari M

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:The clinical features of 80 patients with primary Sjögren's syndrome (PSS) were revised in order to evaluate the descriptive and analytical facilities of a newly proposed model for classification of the exocrine and nonexocrine disease manifestations in PSS. DESIGN:Retrospective, long-term (median 7.5 years...

journal_title：Journal of internal medicine

authors： Asmussen K,Andersen V,Bendixen G,Schiødt M,Oxholm P

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:To examine the feasibility and efficacy of a multifactorial intervention programme directed towards hypercholesterolaemia, smoking, and diabetes mellitus in treated hypertensive patients after more than 3 years' follow-up and to describe the incidence of cardiovascular complications. DESIGN:Open, randomized,...

journal_title：Journal of internal medicine

authors： Agewall S,Wikstrand J,Samuelsson O,Persson B,Andersson OK,Fagerberg B

更新日期：1994-12-01 00:00:00

abstract：:Gene mutations at the low density lipoprotein (LDL) receptor locus were screened in 210 alleles of Japanese patients with familial hypercholesterolaemia (FH). In the present study, two types of novel mutation were identified by genomic Southern blotting using human LDL receptor cDNA probes. An approximately 12 kb dele...

journal_title：Journal of internal medicine

authors： Kajinami K,Mabuchi H,Inazu A,Fujita H,Koizumi J,Takeda R,Matsue T,Kibata M

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVES:The objective of the study was to determine whether an association between diet and platelet function, plasma fibrinogen level and factor VII coagulant activity (VII:C) could be established in young subjects. DESIGN:Data on the habitual diet of the subjects were collected either by a questionnaire on food h...

journal_title：Journal of internal medicine

authors： Mutanen M,Krusius T,Räsänen L,Freese R,Vahtera E,Viikari JS

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:The RET proto-oncogene is known to be the susceptibility gene for various disease phenotypes, including multiple endocrine neoplasia type 2 (MEN 2). Recent studies have also suggested an involvement of RET in the development of the mammalian kidney. Although kidney agenesis or dysgenesis has been observed in ...

journal_title：Journal of internal medicine

authors： Loré F,Talidis F,Di Cairano G,Renieri A

更新日期：2001-07-01 00:00:00

abstract：:Type 2 diabetes (T2DM) is a rapidly growing public health problem. It is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. The factors underlying incre...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2018-02-01 00:00:00

abstract：:In a 24-week randomized multicentre single-blind study, including mild to moderate hypertensives free from other diseases, the effect on blood lipids of captopril (n = 51) was studied and compared with that of metoprolol (n = 53). In order to keep the diastolic pressure less than 95 mm Hg, bendroflumethiazide was adde...

journal_title：Journal of internal medicine

authors： Foss OP,Jensen EK

更新日期：1990-02-01 00:00:00

abstract：:The introduction of targeted biological therapies has revolutionised the management of immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. Following treatment with these therapies, many patients experience significant improvement...

journal_title：Journal of internal medicine

authors： Isaacs JD,Cutolo M,Keystone EC,Park W,Braun J

更新日期：2016-01-01 00:00:00

abstract：:To determine the folic acid absorption characteristics of patients with human immunodeficiency virus (HIV) infection, a prospective, controlled, result-blind single-dose oral absorption study was conducted. A total of 25 subjects were fasted and given 5 mg oral folic acid; blood samples were taken at time zero and aft...

journal_title：Journal of internal medicine

authors： Revell P,O'Doherty MJ,Tang A,Savidge GF

更新日期：1991-09-01 00:00:00

abstract：:Chronic nonvalvular atrial fibrillation is associated with an overall risk of thromboembolic complications of 4.5% per year. Advancing age, prior stroke or transient cerebral ischaemia, diabetes, hypertension, and impaired function of the left ventricle are known risk factors. Placebo-controlled trials have demonstrat...

journal_title：Journal of internal medicine

authors： Koefoed BG,Petersen P

更新日期：1999-04-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX are tendon xanthomas, cataracts and progressive neurological dysfunction. Here, we characterize an adult fem...

journal_title：Journal of internal medicine

authors： Hansson M,Olin M,Floren CH,von Bahr S,van't Hooft F,Meaney S,Eggertsen G,Björkhem I

更新日期：2007-05-01 00:00:00

abstract：:We observed two patients with hypercholesterolaemia and tendon xanthomas associated with apolipoprotein (apoE-7) E-7, a rare variant of the apoE isoforms. Both suffered from coronary artery disease and had undergone a coronary bypass operation. Their cholesterol levels were 268 and 310 mg dl-1, respectively. Both pati...

journal_title：Journal of internal medicine

authors： Ueyama Y,Nozaki S,Yanagi K,Hiraoka H,Nakagawa T,Sakai N,Jiao S,Yamashita S,Matsuzawa Y

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVES:To investigate the concordance of anti-hepatitis C virus (anti-HCV) reactivity by a second-generation enzyme immunoassay (EIA-2) and by a four-antigen recombinant immunoblot assay (4-RIBA) in homosexual men, in comparison with that found in other sexually active groups and blood donors. DESIGN:Prospective s...

journal_title：Journal of internal medicine

authors： Andreu J,Abad MA,Sanchez-Quijano A,Torronteras R,Luque F,Garcia de las Heras J,Soto B,Pineda JA,Leal M,Lissen E

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjögren's syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL). OBJECTIVES:To pr...

journal_title：Journal of internal medicine

authors： Baldini C,Santini E,Rossi C,Donati V,Solini A

更新日期：2017-08-01 00:00:00

abstract：:A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by ...

journal_title：Journal of internal medicine

authors： Habashi HM,Sharp RA,Pippard MJ

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVES:To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline. DESIGN:A population-based, prospective, nested case-referent study. SETTING:Sc...

journal_title：Journal of internal medicine

authors： Hultdin J,Thøgersen AM,Jansson JH,Nilsson TK,Weinehall L,Hallmans G

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Statins reduce low-density lipoprotein cholesterol (LDL-C) and can raise high-density lipoprotein cholesterol (HDL-C). HDL-bound paraoxonase-1 (PON1) is associated with variations in plasma HDL-C, and may, therefore, contribute to changes of HDL-C during statin therapy. DESIGN:The effects of baseline PON1 s...

journal_title：Journal of internal medicine

authors： Himbergen TM,van Tits LJ,Voorbij HA,de Graaf J,Stalenhoef AF,Roest M

更新日期：2005-11-01 00:00:00

abstract：:Previous studies in patients with peripheral arterial disease (PAD) have shown that the prognosis is relatively good when the distal systolic ankle index (ankle systolic pressure/arm systolic pressure) is above 50% and the distal toe systolic pressure is above 40 mmHg. In 132 patients suspected of PAD in the legs we i...

journal_title：Journal of internal medicine

authors： Christensen JH,Freundlich M,Jacobsen BA,Falstie-Jensen N

更新日期：1989-08-01 00:00:00

abstract：:Lifibrol is a powerful cholesterol-lowering drug of unknown mechanism of action. This investigation was carried out to determine whether the major action of lifibrol is to enhance clearance of low density lipoproteins (LDL) through the LDL-receptor pathway, and if so, whether the drug exerts its action by altering the...

journal_title：Journal of internal medicine

authors： Vega GL,von Bergmann K,Grundy SM,Blumenschein S,Carter NB,Laeis P,Lindenthal B,von Bergmann J,Simatupang A,Lutjohann D,Adams-Huet B

更新日期：1999-07-01 00:00:00

abstract：:A female patient developed warfarin resistance after 2 years of satisfactory therapy. Only a third of orally administered warfarin was absorbed, the clearance of warfarin was normal. The patient was also resistant for dicoumarol, while phenandione had satisfactory effect on the prothrombin time (PT). ...

journal_title：Journal of internal medicine

authors： Talstad I,Gamst ON

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To assess the prophylactic efficacy of aspirin and a high-dose antioxidant vitamin combination in patients with peripheral arterial disease (PAD) in terms of reduction of the risk of a first vascular event (myocardial infarction, stroke, vascular death) and critical limb ischaemia. DESIGN:Randomized, placebo...

journal_title：Journal of internal medicine

authors： Critical Leg Ischaemia Prevention Study (CLIPS) Group.,Catalano M,Born G,Peto R

更新日期：2007-03-01 00:00:00

abstract：:We determined whether ketoconazole prophylaxis might reduce Candida colonization and infections in adult patients with acute leukaemia. During first-remission induction therapy 50 patients were treated with 200 mg ketoconazole administered orally daily, while 57 patients received placebo in a double-blind, randomized ...

journal_title：Journal of internal medicine

authors： Palmblad J,Lönnqvist B,Carlsson B,Grimfors G,Järnmark M,Lerner R,Ljungman P,Nyström-Rosander C,Petrini B,Oberg G

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：:The purpose of this study was to estimate the prevalence of hypertrophic cardiomyopathy (HCM) in 3607 men from the Reykjavik study of 1979-81. Of these, 452 men had an abnormal (group A) and 3155 a normal electrocardiogram. An echocardiographic control group of 128 men was selected from cohorts with a normal electroca...

journal_title：Journal of internal medicine

authors： Agnarsson UT,Hardarson T,Hallgrimsson J,Sigfusson N

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:It has been hypothesized that epicardial adipose tissue (EAT) exerts pathogenic effects on cardiac structures. We analysed the associations between EAT and both cardiovascular (CV) disease risk factors and CV events in patients with chronic kidney disease (CKD). PATIENTS AND METHODS:We included 277 nondialy...

journal_title：Journal of internal medicine

authors： Cordeiro AC,Amparo FC,Oliveira MA,Amodeo C,Smanio P,Pinto IM,Lindholm B,Stenvinkel P,Carrero JJ

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:Cardiac sarcoidosis (CS) without clinically apparent extracardiac disease may escape detection because of the poor sensitivity of endomyocardial biopsy (EMB). We set out to analyse our experience of repeated and imaging-guided biopsies in clinically isolated CS. METHODS:We retrospectively reviewed the medic...

journal_title：Journal of internal medicine

authors： Kandolin R,Lehtonen J,Graner M,Schildt J,Salmenkivi K,Kivistö SM,Kupari M

更新日期：2011-11-01 00:00:00