Abstract：
OBJECTIVE:Plasma fibrinogen predicts cardiovascular events in patients with stable peripheral arterial occlusive disease, but its predictive value in patients with chronic critical limb ischaemia, a condition associated with a high risk of death, is unknown. DESIGN:A prospective cohort study. SETTING:Determination of fibrinogen and other potential predictors during clinic-based work-up of patients admitted for diagnostic and therapeutic evaluation. SUBJECTS:A total of 108 patients (72 +/- 10 years, 78 males) with atherosclerotic occlusive disease and critical limb ischaemia (pain at rest and/or trophic lesions) followed up for a median period of 1.6 years). (range: 8 days-5.5 years; 218 patient-years). MAIN OUTCOME MEASURES:Total mortality. RESULTS:Forty-five deaths (71% cardiovascular) occurred during the follow-up. Baseline fibrinogen was higher in those who died in the early follow-up period (first 6 months), as were white cell count and serum creatinine, while haematocrit was lower. Plasma fibrinogen values correlated positively with white cell count, and negatively with haematocrit; other cardiovascular prognostic factors did not differ. Only plasma fibrinogen predicted survival independently in multivariate age-corrected Cox regression analysis. Relative risk of death doubled for each standard deviation above the mean and increased with each tertile increase in fibrinogen. CONCLUSIONS:Fibrinogen predicted death in these elderly arteriopaths with critical limb ischaemia, particularly those who died in the first months following critical ischaemia. Inflammatory stimuli secondary to severely defective tissue oxygenation and possibly sepsis and necrosis, might have stimulated fibrinogen, an acute-phase reactant, thereby compromising organ perfusion through increased blood viscosity and/or promoting thrombosis.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Pedrinelli R,Dell' Omo G,Barchielli A,Berchiolli R,Melillo E,Mariani M,Balbarini A,Ferrari Mdoi
10.1046/j.1365-2796.1999.00410.xsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
75-81issue
1eissn
0954-6820issn
1365-2796journal_volume
245pub_type
杂志文章abstract：:Breast cancer is not only increasing in the west but also particularly rapidly in eastern countries where traditionally the incidence has been low. The rise in incidence is mainly related to changes in reproductive patterns and lifestyle. These trends could potentially be reversed by defining women at greatest risk an...
journal_title：Journal of internal medicine
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doi：10.1111/j.1365-2796.2012.02525.x
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journal_title：Journal of internal medicine
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doi：10.1046/j.1365-2796.1998.00346.x
更新日期：1998-06-01 00:00:00
abstract：AIM:There is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations betw...
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pub_type： 杂志文章,评审
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb01380.x
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVE:Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-med...
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journal_title：Journal of internal medicine
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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journal_title：Journal of internal medicine
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doi：10.1111/j.1365-2796.1997.tb00012.x
更新日期：1997-06-01 00:00:00
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journal_title：Journal of internal medicine
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更新日期：2020-12-30 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1990.tb00120.x
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:The cell cycle regulator cyclin D1 plays an important role in parathyroid tumourigenesis. The NciI polymorphism in exon 4 has recently been associated with early onset of hereditary nonpolyposis colorectal cancer and is a prognostic indicator of nonsmall cell lung cancer and squamous cell carcinomas. Further...
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doi：10.1046/j.1365-2796.2001.00912.x
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journal_title：Journal of internal medicine
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doi：10.1111/j.1365-2796.1995.tb01189.x
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pub_type： 杂志文章,随机对照试验
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更新日期：2008-07-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.1990.tb00174.x
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abstract：:Primary hyperparathyroidism (HPT) has been associated with hypertension, hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. In the present study, plasma ionized calcium (Ca2+) was studied in relation to cardiovascular risk factors in 20 subjects with mild hypertension. Plasma Ca2+ was found to be negatively ...
journal_title：Journal of internal medicine
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doi：10.1111/j.1365-2796.1993.tb00706.x
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journal_title：Journal of internal medicine
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-12-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2006.01647.x
更新日期：2006-05-01 00:00:00
abstract：:Sepsis is a major clinical problem in intensive care. The mortality in septic shock is high, and predominantly due to cardiovascular collapse and multiple organ dysfunction. In sepsis high levels of circulating hyaluronan have been found, correlating to disease severity and prognosis. The reason behind the increased l...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
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更新日期：1997-07-01 00:00:00
abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12945
更新日期：2019-10-01 00:00:00
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journal_title：Journal of internal medicine
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1111/joim.12724
更新日期：2018-05-01 00:00:00
abstract：:We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.100115000.x
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVES:Single nucleotide polymorphisms in genes encoding inflammatory molecules may determine genetic profiles associated with increased risk of development and progression of cardiovascular diseases. In this study, we evaluated distribution and reciprocal interaction of a set of functionally important polymorphism...
journal_title：Journal of internal medicine
pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
