Plasma fibrinogen--an independent cardiovascular risk factor.

abstract：:The B lymphocyte-associated antigen CD20 is becoming an important immunotherapy target for autoimmune diseases, although its biological function has not been defined. Besides rheumatoid arthritis, growing experience with B cell-depleting therapy indicates that it may be effective in Sjögren's syndrome, dermatomyositis...

journal_title：Journal of internal medicine

authors： Perosa F,Prete M,Racanelli V,Dammacco F

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at...

journal_title：Journal of internal medicine

authors： Fossum E,Gleim GW,Kjeldsen SE,Kizer JR,Julius S,Devereux RB,Brady WE,Hille DA,Lyle PA,Dahlöf B

更新日期：2007-10-01 00:00:00

abstract：:In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood pressure was in the range 95-120 mmHg were randomly allocated to groups that received either hydrochlorothiazide or metoprolol, or both drugs when the response to one of them was...

journal_title：Journal of internal medicine

authors： Monmany J,Domingo P,Gomez JA,Sanz F,Roca-Cusachs A,Nolla J,Jane F

更新日期：1990-10-01 00:00:00

abstract：:Primary hyperparathyroidism (HPT) has been associated with hypertension, hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. In the present study, plasma ionized calcium (Ca2+) was studied in relation to cardiovascular risk factors in 20 subjects with mild hypertension. Plasma Ca2+ was found to be negatively ...

journal_title：Journal of internal medicine

authors： Lind L,Wengle B,Lithell H,Ljunghall S

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVES:Small LDL particle size has been shown to be associated with coronary artery disease. However, no previous study has been performed relating LDL particle size to ultrasound measurement of atherosclerosis in hypercholesterolaemic subjects. The main aims of the present study were therefore: (i) to investigate ...

journal_title：Journal of internal medicine

authors： Hulthe J,Wiklund O,Bondjers G,Wikstrand J

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-...

journal_title：Journal of internal medicine

authors： Agewall S,Fagerberg B,Berglund G,Schmidt C,Wendelhag I,Wikstrand J,Risk Factor Intervention Study Group, Sweden.

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:To investigate the concordance of anti-hepatitis C virus (anti-HCV) reactivity by a second-generation enzyme immunoassay (EIA-2) and by a four-antigen recombinant immunoblot assay (4-RIBA) in homosexual men, in comparison with that found in other sexually active groups and blood donors. DESIGN:Prospective s...

journal_title：Journal of internal medicine

authors： Andreu J,Abad MA,Sanchez-Quijano A,Torronteras R,Luque F,Garcia de las Heras J,Soto B,Pineda JA,Leal M,Lissen E

更新日期：1994-07-01 00:00:00

abstract：:A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

journal_title：Journal of internal medicine

authors： Berkman N,Meirow D,Katzir Z,Bar-On H

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular disease mandates further exploration of the integrated metabolism of chylomicrons and very low-density lipoproteins (VLDL). METHODS:Novel tracer techniques and an integrated multi-compartmental model were used to determ...

journal_title：Journal of internal medicine

authors： Björnson E,Packard CJ,Adiels M,Andersson L,Matikainen N,Söderlund S,Kahri J,Hakkarainen A,Lundbom N,Lundbom J,Sihlbom C,Thorsell A,Zhou H,Taskinen MR,Borén J

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Sunlight exposure of the skin is known to be the most important source of vitamin D. The aims of this study were: (i) to estimate vitamin D status amongst sunlight-deprived individuals (veiled Arab women, veiled ethnic Danish Moslem women and Danish controls); and (ii) through food intake analysis to estimat...

journal_title：Journal of internal medicine

authors： Glerup H,Mikkelsen K,Poulsen L,Hass E,Overbeck S,Thomsen J,Charles P,Eriksen EF

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurre...

journal_title：Journal of internal medicine

authors： Jönsson D,Orho-Melander M,Demmer RT,Engström G,Melander O,Klinge B,Nilsson PM

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:There is uncertainty amongst clinicians about the definitions of cobalamin and folate deficiency and therefore about the indications for treatment. In this report we present the results of systematic cobalamin and folic acid treatment based upon serum cobalamin, total homocysteine (tHcy) and methylmalonic ac...

journal_title：Journal of internal medicine

authors： Björkegren K,Svärdsudd K

更新日期：1999-09-01 00:00:00

abstract：INTRODUCTION:The bb genotype of the BsmI polymorphism of the vitamin D receptor (VDR) is more common in primary hyperparathyroidism (HPT) than in the general population in Swedish and German women. However, little is known about the association of HPT with the start codon polymorphism of the VDR (defined by FokI). OBJ...

journal_title：Journal of internal medicine

authors： Sosa M,Torres A,Martín N,Salido E,Limiñana JM,Barrios Y,De Miguel E,Betancor P

更新日期：2000-01-01 00:00:00

abstract：:This study was performed to evaluate thyroid and adrenal function in patients with familial amyloidotic polyneuropathy. Twenty-four patients without any clinical overt endocrinological dysfunction were studied. None of the patients showed laboratory evidences of hypo- or hyperthyroidism. A short ACTH-stimulation test ...

journal_title：Journal of internal medicine

authors： Olofsson BO,Grankvist K,Boman K,Forsberg K,Lafvas I,Lithner F

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Patients undergoing bariatric surgery present long-term metabolic improvements and reduced type 2 diabetes risk, despite long-term weight regain. We hypothesized that part of these protective effects could be linked to altered gene expression in white adipose tissue (WAT). METHODS:Transcriptomic profiling by...

journal_title：Journal of internal medicine

authors： Kerr AG,Andersson DP,Rydén M,Arner P,Dahlman I

更新日期：2020-08-01 00:00:00

abstract：:A 59-year-old male patient presented with invalidating osteomalacia of 2.5 years' duration. The osteomalacia was caused by severe malabsorption due to gluten-sensitive enteropathy (GSE). There were no other signs or symptoms of GSE in this patient. Clinical presentation with monosymptomatic osteomalacia is very unusua...

journal_title：Journal of internal medicine

authors： De Boer WA,Tytgat GN

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVES:To establish a population-based 24-h ambulatory blood pressure (ABP) reference material with day/night mean BP calculated by standardized and true bedtimes. DESIGN:A cross-sectional study of 200 randomly selected subjects (20 men and 20 women in each 10-year age interval 20-70 years) in Linköping, Sweden. ...

journal_title：Journal of internal medicine

authors： Nyström F,Malmström O,Karlberg BE,Ohman KP

更新日期：1996-11-01 00:00:00

abstract：:A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by ...

journal_title：Journal of internal medicine

authors： Habashi HM,Sharp RA,Pippard MJ

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to ascertain the degree of occurrence of tuberculous infection in patients presenting with low back pain (LBP). METHODS:Forty consecutive patients seeking primary medical attention for the main symptom of LBP and presenting to the Rheumatology Outpatient Clinic of our institu...

journal_title：Journal of internal medicine

authors： Abou-Raya S,Abou-Raya A

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2016-10-01 00:00:00

abstract：:Neuroendocrine tumour of the small intestine (SI-NET), formerly known as midgut carcinoid tumour, is the most common small intestinal malignancy. The incidence is rising, with recent reports of 0.67 per 100 000 in the USA and 1.12 per 100 000 in Sweden. SI-NETs often present a challenge in terms of diagnosis and treat...

journal_title：Journal of internal medicine

authors： Stålberg P,Westin G,Thirlwell C

更新日期：2016-12-01 00:00:00

abstract：:Hypertriglyceridaemia, as defined by fasting triglyceride levels of greater than 2.8 mmol l-1, is a prevalent dyslipoproteinaemia in our population. The underlying pathophysiological mechanisms that result in elevations of plasma triglycerides are heterogeneous and, in most cases, incompletely understood. However, in ...

journal_title：Journal of internal medicine

authors： Fojo SS,Brewer HB

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Hyponatremia is a common feature of acute illness and associated with increased mortality. This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption. OBJECTIVES:To investigate whether the association between hyponatremia and mortality could b...

journal_title：Journal of internal medicine

authors： Eckart A,Hausfater P,Amin D,Amin A,Haubitz S,Bernard M,Baumgartner A,Struja T,Kutz A,Christ-Crain M,Huber A,Mueller B,Schuetz P

更新日期：2018-09-01 00:00:00

abstract：:In the developed world the majority of disease results from common, but complex disorders such as diabetes, obesity and cancer. Genetic variation explains a large proportion of an individual's risk of developing these diseases; however, success in identifying the particular gene variants involved has been limited. Rec...

journal_title：Journal of internal medicine

authors： Lango H,Weedon MN

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Studies on extracranial carotid atherosclerosis have predominately been undertaken on middle-aged subjects. This study examines the prevalence of extracranial carotid atherosclerosis, its relation to vascular risk factors and its significance for survival in elderly subjects. DESIGN:Population-based cross-s...

journal_title：Journal of internal medicine

authors： Hillen T,Nieczaj R,Münzberg H,Schaub R,Borchelt M,Steinhagen-Thiessen E

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Study patient characteristics, morbidity patterns and drug regimens associated with fatal adverse drug events (FADEs) amongst medical department inpatients. DESIGN:An observational, descriptive study using aggregated medical records, autopsies and pre and postmortem drug analyses. SETTING:A department of in...

journal_title：Journal of internal medicine

authors： Buajordet I,Ebbesen J,Erikssen J,Brørs O,Hilberg T

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Platelet-activating factor (PAF) is a phospholipid inflammatory mediator which is synthesized by a variety of cells, including monocytes and endothelial cells, and PAF can be retained in activated endothelial cell membranes. Furthermore, PAF-like lipids are produced in other phospholipid membranes as in oxidi...

journal_title：Journal of internal medicine

authors： Wu R,Lemne C,De Faire U,Frostegârd J

更新日期：1999-10-01 00:00:00

abstract：:Autoantibodies against three different postsynaptic antigens and one presynaptic antigen at the neuromuscular junction are known to cause myasthenic syndromes. The mechanisms by which these antibodies cause muscle weakness vary from antigenic modulation and complement-mediated membrane damage to inhibition of endogeno...

journal_title：Journal of internal medicine

authors： Huijbers MG,Lipka AF,Plomp JJ,Niks EH,van der Maarel SM,Verschuuren JJ

更新日期：2014-01-01 00:00:00