Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia.

abstract：OBJECTIVES:A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke...

journal_title：Journal of internal medicine

authors： Frost L,Johnsen SP,Pedersen L,Toft E,Husted S,Sørensen HT

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Echocardiographically determined left atrioventricular plane displacement (AVPD) is strongly related to prognosis in patients with chronic heart failure and in postmyocardial infarction patients. We aimed at exploring whether AVPD, unlike ejection fraction, is related to mortality in patients with stable cor...

journal_title：Journal of internal medicine

authors： Rydberg E,Erhardt L,Brand B,Willenheimer R

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To explore the relation between 25-hydroxyvitamin D deficiency and frailty. Frailty is a multidimensional phenotype that describes declining physical function and a vulnerability to adverse outcomes in the setting of physical stress such as illness or hospitalization. Low serum concentrations of 25-hydroxyvit...

journal_title：Journal of internal medicine

authors： Wilhelm-Leen ER,Hall YN,Deboer IH,Chertow GM

更新日期：2010-08-01 00:00:00

abstract：:A female patient developed warfarin resistance after 2 years of satisfactory therapy. Only a third of orally administered warfarin was absorbed, the clearance of warfarin was normal. The patient was also resistant for dicoumarol, while phenandione had satisfactory effect on the prothrombin time (PT). ...

journal_title：Journal of internal medicine

authors： Talstad I,Gamst ON

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the prognostic value of exercise testing performed soon after acute myocardial infarction (AMI) in patients treated with thrombolytic therapy. DESIGN:A 1-year prospective follow-up of 185 subjects treated with thrombolytic therapy who survived AMI, and who performed exercise testing 3 weeks afte...

journal_title：Journal of internal medicine

authors： Abboud L,Hir J,Eisen I,Markiewicz W

更新日期：1994-11-01 00:00:00

abstract：:In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hypergl...

journal_title：Journal of internal medicine

authors： Thorens B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:We aimed to study the effect of social containment mandates on ACS presentation during COVID-19 pandemic using location activity and mobility data from mobile phone map services. METHODS:We conducted a cross-sectional study using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) in...

journal_title：Journal of internal medicine

authors： Mohammad MA,Koul S,Gale CP,Alfredsson J,James S,Fröbert O,Omerovic E,Erlinge D

更新日期：2021-02-01 00:00:00

abstract：:Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanism...

journal_title：Journal of internal medicine

authors： Shacklett BL,Critchfield JW,Ferre AL,Hayes TL

更新日期：2009-01-01 00:00:00

abstract：:We investigated skeletal involvement in five male and two female patients with ochronosis, aged 26-82 years. The main parameters of mineral metabolism, together with biochemical markers of bone resorption (urinary N-telopeptides of type I collagen) and formation (serum bone isoenzyme of alkaline phosphatase and serum ...

journal_title：Journal of internal medicine

authors： Aliberti G,Pulignano I,Schiappoli A,Minisola S,Romagnoli E,Proietta M

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To investigate the demographic, clinical, biochemical and genotypic features of patients with erythropoietic protoporphyria (EPP) in a Swedish cohort. DESIGN:Cross-sectional questionnaire, biochemical and genetic study. SETTING:Sweden. SUBJECTS:Fifty-one Swedish individuals known in 2008 to have EPP confir...

journal_title：Journal of internal medicine

authors： Wahlin S,Floderus Y,Stål P,Harper P

更新日期：2011-03-01 00:00:00

abstract：:Infection of mural thrombus over an area of old myocardial infarct was found in an elderly woman with cholangitis. This case is unique since cholangitis was thought to be the cause of septicaemia and ventricular aneurysm was not present. ...

journal_title：Journal of internal medicine

authors： Cheung A,Choi A

更新日期：1990-04-01 00:00:00

abstract：:Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'om...

journal_title：Journal of internal medicine

authors： Bergström G,Berglund G,Blomberg A,Brandberg J,Engström G,Engvall J,Eriksson M,de Faire U,Flinck A,Hansson MG,Hedblad B,Hjelmgren O,Janson C,Jernberg T,Johnsson Å,Johansson L,Lind L,Löfdahl CG,Melander O,Östgren CJ,

更新日期：2015-12-01 00:00:00

abstract：:Transplantation of foetal dopamine neurons into the striatum of Parkinson's disease patients can provide restoration of the dopamine system and alleviate motor deficits. However, cellular replacement is associated with several problems. As with pharmacological treatments, cell therapy can lead to disabling abnormal in...

journal_title：Journal of internal medicine

authors： Hedlund E,Perlmann T

更新日期：2009-10-01 00:00:00

abstract：:A case of a clinically occult ovarian carcinoma leading to subacute cor pulmonale in a 62-year-old woman is described. The patient was admitted to hospital with increasing respiratory distress. Physical examination and echocardiography showed signs of pulmonary hypertension. She died from circulatory failure. Autopsy ...

journal_title：Journal of internal medicine

authors： Lambert-Jensen P,Mertz H,Nyvad O,Christensen JH

更新日期：1994-11-01 00:00:00

abstract：:To determine the folic acid absorption characteristics of patients with human immunodeficiency virus (HIV) infection, a prospective, controlled, result-blind single-dose oral absorption study was conducted. A total of 25 subjects were fasted and given 5 mg oral folic acid; blood samples were taken at time zero and aft...

journal_title：Journal of internal medicine

authors： Revell P,O'Doherty MJ,Tang A,Savidge GF

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology, pathogenesis and clinical features of hepatocellular carcinoma (HCC) in patients with acute intermittent porphyria (AIP). DESIGN:A retrospective population-based mortality study. SUBJECTS:All inhabitants who died between 1978-1990 (2122) including 33 with AIP, in two municipali...

journal_title：Journal of internal medicine

authors： Andersson C,Bjersing L,Lithner F

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult. METHODS:Markers of cardiac stress (B-type natriuretic peptide, BNP) and inflammation (C-reactive protein, white blood cell count, procalcitonin) as well as t...

journal_title：Journal of internal medicine

authors： Christ-Crain M,Breidthardt T,Stolz D,Zobrist K,Bingisser R,Miedinger D,Leuppi J,Tamm M,Mueller B,Mueller C

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

journal_title：Journal of internal medicine

authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients. DESIGN AND SETTING:This double-blind randomised placebo-controlled trial was performed at the dialysis department of...

journal_title：Journal of internal medicine

authors： Diepeveen SH,Verhoeven GW,Van Der Palen J,Dikkeschei LD,Van Tits LJ,Kolsters G,Offerman JJ,Bilo HJ,Stalenhoef AF

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of the common Finnish and Norwegian mutations in the low density lipoprotein (LDL) receptor gene in Swedish patients with familial hypercholesterolaemia (FH), and to start screening for other mutations in these patients. In contrast to the situation in Norway and Finland, where the f...

journal_title：Journal of internal medicine

authors： Lind S,Eriksson M,Rystedt E,Wiklund O,Angelin B,Eggertsen G

更新日期：1998-07-01 00:00:00

abstract：:The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), is rising globally. Dietary lipid over supply leads to lipid accumulation at ectopic sites, such as skeletal muscle. Ectopic lipid storage is highly correlated with insulin resistance and T2D, likely due to a loss of metabolic flex...

journal_title：Journal of internal medicine

authors： Zacharewicz E,Hesselink MKC,Schrauwen P

更新日期：2018-11-01 00:00:00

abstract：:Multimorbidity, the simultaneous presence of multiple health conditions in an individual, is an increasingly common phenomenon globally. The systematic assessment of the quality of care delivered to people with multimorbidity will be key to informing the organization of services for meeting their complex needs. Yet, c...

journal_title：Journal of internal medicine

authors： Valderas JM,Gangannagaripalli J,Nolte E,Boyd CM,Roland M,Sarria-Santamera A,Jones E,Rijken M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) are often asymptomatic. Angiogenesis is implicated in the physiology of vascular repair and cardiac remodelling, and is one of many pathophysiological processes implicated in heart failure. We hypothesized that plasm...

journal_title：Journal of internal medicine

authors： Patel JV,Abraheem A,Chackathayil J,Gunning M,Creamer J,Hughes EA,Lip GY

更新日期：2009-05-01 00:00:00

abstract：:Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaph...

journal_title：Journal of internal medicine

authors： Serini G,Bussolino F,Maione F,Giraudo E

更新日期：2013-02-01 00:00:00

abstract：:Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system, is today a leading cause of unpredictable lifelong disability in young adults. The treatment of patients in progressive stages remains highly challenging, alluding to our limited understanding of ...

journal_title：Journal of internal medicine

authors： Kular L,Jagodic M

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To evaluate (i) the demineralizing effect of L-thyroxine (LT4) therapy at doses mildly inhibiting serum thyroid stimulating hormone (TSH) in patients with benign nodular goitre; (ii) the efficacy of treatment on nodule size. DESIGN:Cross-sectional study comparing euthyroid women with nodular goitre treated ...

journal_title：Journal of internal medicine

authors： Baldini M,Gallazzi M,Orsatti A,Fossati S,Leonardi P,Cantalamessa L

更新日期：2002-05-01 00:00:00

abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2016-10-01 00:00:00

abstract：:Neutrophil granules store proteins that are critically important for the neutrophil to move from the vascular bed to tissues and to kill microorganisms. This is illustrated in nature when individual proteins are deleted due to inherited mutations of their cognate genes, and such deficiencies result in the conditions l...

journal_title：Journal of internal medicine

authors： Häger M,Cowland JB,Borregaard N

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient's basal...

journal_title：Journal of internal medicine

authors： Recalde-Zamacona B,Tomás-Velázquez A,Campo A,Satrústegui-Alzugaray B,Fernández-Alonso M,Iñigo M,Rodríguez-Mateos M,Di Frisco M,Felgueroso C,Bertó J,Marín-Oto M,Alcaide AB,Zulueta JJ,Seijo L,Landecho MF

更新日期：2020-12-29 00:00:00