Mucosal T-cell responses to HIV: responding at the front lines.

Abstract:

:Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8(+) cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.

journal_name

J Intern Med

authors

Shacklett BL,Critchfield JW,Ferre AL,Hayes TL

doi

10.1111/j.1365-2796.2008.02042.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

58-66

issue

1

eissn

0954-6820

issn

1365-2796

pii

JIM2042

journal_volume

265

pub_type

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