Neuronal cell replacement in Parkinson's disease.

Abstract:

:Transplantation of foetal dopamine neurons into the striatum of Parkinson's disease patients can provide restoration of the dopamine system and alleviate motor deficits. However, cellular replacement is associated with several problems. As with pharmacological treatments, cell therapy can lead to disabling abnormal involuntary movements (dyskinesias). The exclusion of serotonin and GABA neurons, and enrichment of substantia nigra (A9) dopamine neurons, may circumvent this problem. Furthermore, although grafted foetal dopamine neurons can survive in Parkinson's patients for more than a decade, the occurrence of Lewy bodies within such transplanted cells and reduced dopamine transporter and tyrosine hydroxylase expression levels indicate that grafted cells are associated with pathology. It will be important to understand if such abnormalities are host- or graft induced and to develop methods to ensure survival of functional dopamine neurons. Careful preparation of cellular suspensions to minimize graft-induced inflammatory responses might influence the longevity of transplanted cells. Finally, a number of practical and ethical issues are associated with the use of foetal tissue sources. Thus, future cell therapy is aiming towards the use of embryonic stem cell or induced pluripotent stem cell derived dopamine neurons.

journal_name

J Intern Med

authors

Hedlund E,Perlmann T

doi

10.1111/j.1365-2796.2009.02155.x

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

358-71

issue

4

eissn

0954-6820

issn

1365-2796

pii

JIM2155

journal_volume

266

pub_type

杂志文章,评审
  • Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males.

    abstract:OBJECTIVES:To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia. DESIGN:A prospective study. SETTING:Helsinki University Central Hospital, Finland. SUBJECTS:Seventy-one healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin sen...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1997.tb00002.x

    authors: Hautanen A,Räikkönen K,Adlercreutz H

    更新日期:1997-06-01 00:00:00

  • Prevalence and extent of subclinical atherosclerosis in patients with psoriasis.

    abstract:OBJECTIVE:Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN:A cross-sectional study. SETTING AND SUBJECTS:The prevalence and extent of coronary and car...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/joim.12002

    authors: Yiu KH,Yeung CK,Zhao CT,Chan JC,Siu CW,Tam S,Wong CS,Yan GH,Yue WS,Khong PL,Chan HH,Tse HF

    更新日期:2013-03-01 00:00:00

  • Acute and chronic pancreatic disease associated with Yersinia enterocolitica infection: a Norwegian 10-year follow-up study of 458 hospitalized patients.

    abstract::During the period 1974-1983, Yersinia enterocolitica infection was diagnosed in 458 hospitalized patients by antibody response or isolation of the micro-organism. Eight (1.75%) patients showed signs of acute pancreatitis with elevated serum or urine levels of amylase; two patients had acute insulin-dependent diabetes....

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1992.tb00970.x

    authors: Saebø A,Lassen J

    更新日期:1992-05-01 00:00:00

  • Stroke event rates in anticoagulated patients with paroxysmal atrial fibrillation.

    abstract:AIMS:To test the hypothesis that stroke and systemic embolic events (SEE) in the stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) III and V trials are different between paroxysmal and persistent atrial fibrillation (AF). METHODS:Data analysis from two cohorts of patients enrolled in ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2796.2007.01909.x

    authors: Lip GY,Frison L,Grind M,SPORTIF Investigators.

    更新日期:2008-07-01 00:00:00

  • Twins and the mystery of missing heritability: the contribution of gene-environment interactions.

    abstract::Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic var...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2012.02587.x

    authors: Kaprio J

    更新日期:2012-11-01 00:00:00

  • Risk factors for benign oesophageal disease in a random population sample.

    abstract::The association of sex, age, relative weight, smoking and drinking habits, chronic obstructive pulmonary disease (COPD) and economic and marital status, with benign oesophageal disease (BOD) was investigated by means of a point-prevalence study of BOD in a Danish population. A total of 346 individuals, representing su...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1991.tb00399.x

    authors: Andersen LI,Jensen G

    更新日期:1991-07-01 00:00:00

  • Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

    abstract::A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for c...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2006.01725.x

    authors: Björkhem I

    更新日期:2006-12-01 00:00:00

  • Prevalence of hyperinsulinaemia in patients with high blood pressure.

    abstract::A total of 41 patients with hypertension were identified in a survey of 732 healthy factory workers. Twenty-three of these individuals were receiving antihypertensive medication, whereas 18 cases were newly discovered. Plasma glucose and insulin responses to oral glucose and fasting plasma triglyceride (TG), cholester...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1992.tb00529.x

    authors: Zavaroni I,Mazza S,Dall'Aglio E,Gasparini P,Passeri M,Reaven GM

    更新日期:1992-03-01 00:00:00

  • Biofilm formation - what we can learn from recent developments.

    abstract::Although biofilms have been observed early in the history of microbial research, their impact has only recently been fully recognized. Biofilm infections, which contribute to up to 80% of human microbial infections, are associated with common human disorders, such as diabetes mellitus and poor dental hygiene, but also...

    journal_title:Journal of internal medicine

    pub_type:

    doi:10.1111/joim.12782

    authors: Bjarnsholt T,Buhlin K,Dufrêne YF,Gomelsky M,Moroni A,Ramstedt M,Rumbaugh KP,Schulte T,Sun L,Åkerlund B,Römling U

    更新日期:2018-10-01 00:00:00

  • Medicine and science in the fight against doping in sport.

    abstract::The fight against doping in sports commenced as a result of the death of a Danish cyclist during the Rome Olympic Games in 1960. The International Olympic Committee (IOC) established a Medical Commission (IOC-MC) which had the task of designing a strategy to combat the misuse of drugs in Olympic Sport. Some Internatio...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2008.01993.x

    authors: Catlin DH,Fitch KD,Ljungqvist A

    更新日期:2008-08-01 00:00:00

  • Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up.

    abstract:OBJECTIVES:The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2796.2001.00818.x

    authors: Agewall S,Fagerberg B,Berglund G,Schmidt C,Wendelhag I,Wikstrand J,Risk Factor Intervention Study Group, Sweden.

    更新日期:2001-04-01 00:00:00

  • Lipid lowering in severe familial hypercholesterolaemia: efficacy and safety of a new regenerating system for selective apheresis of apolipoprotein B-containing lipoproteins.

    abstract::Preliminary experience of the efficacy and safety of a new regenerating system for selective extracorporeal removal of apolipoprotein B-containing lipoproteins is described. Four patients with familial hyperlipoproteinaemia were studied on 10 occasions. A system of two, parallel, dextran sulphate cellulose columns was...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1989.tb00032.x

    authors: Eriksson M,Berg B,Berglund L,Lantz B,Angelin B

    更新日期:1989-01-01 00:00:00

  • Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.

    abstract:OBJECTIVES:To study fasting and postmethionine-loading (increment and decrement) plasma homocysteine levels in end-stage renal disease (ESRD) patients in relation to B-vitamin status and after folic acid treatment without or with betaine. DESIGN:Plasma total homocysteine (tHcy) and methionine levels were measured in c...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2796.1999.00430.x

    authors: van Guldener C,Janssen MJ,de Meer K,Donker AJ,Stehouwer CD

    更新日期:1999-02-01 00:00:00

  • Localized tuberculosis of the oesophagus: a rare condition.

    abstract::This report describes the case of a male patient with progressive dysphagia, epigastric pain, odynophagia, generalized weakness and a mid-oesophagus ulceration in which biopsies showed acid-fast bacilli and histological evidence of tuberculosis. Culture of the biopsies and the sputum revealed mycobacterium tuberculosi...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1995.tb00902.x

    authors: Leotta SM,Elsborg L

    更新日期:1995-07-01 00:00:00

  • Pharmacogenomic biomarkers for personalized cancer treatment.

    abstract::Personalized medicine involves the selection of the safest and most effective pharmacological treatment based on the molecular characteristics of the patient. In the case of anticancer drugs, tumour cell alterations can have a great impact on drug activity and, in fact, most biomarkers predicting response originate fr...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.12321

    authors: Rodríguez-Antona C,Taron M

    更新日期:2015-02-01 00:00:00

  • Bone marrow or peripheral blood stem cell transplantation from unrelated donors in adult patients with acute myeloid leukaemia, an Acute Leukaemia Working Party analysis in 2262 patients.

    abstract:BACKGROUND:No survival benefit of using blood stem cells instead of bone marrow (BM) has been shown in matched unrelated donor (MUD) transplantation. DESIGN AND METHODS:In a retrospective registry analysis, we compared the use of blood stem cells (n = 1502) and BM (n = 760) from unrelated donors in patients aged 18-60...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2012.02547.x

    authors: Ringdén O,Labopin M,Beelen DW,Volin L,Ehninger G,Finke J,Greinix HT,Kyrcz-Krzemien S,Bunjes D,Brinch L,Niederwieser D,Arnold R,Mohty M,Rocha V,Acute Leukaemia Working Party of European Group for Blood and Marrow Transplantati

    更新日期:2012-11-01 00:00:00

  • Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia.

    abstract:OBJECTIVES:Single nucleotide polymorphisms in genes encoding inflammatory molecules may determine genetic profiles associated with increased risk of development and progression of cardiovascular diseases. In this study, we evaluated distribution and reciprocal interaction of a set of functionally important polymorphism...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2007.01791.x

    authors: Flex A,Gaetani E,Angelini F,Sabusco A,Chillà C,Straface G,Biscetti F,Pola P,Castellot JJ Jr,Pola R

    更新日期:2007-07-01 00:00:00

  • Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTc-MOAB.

    abstract:AIM:Prevalence, optimal diagnostic approach and consequences of clinically unsuspected osteomyelitis in diabetic foot ulcers are unclear. Early diagnosis of this infection may be crucial to ensure correct management. METHODS:We conducted a prospective study in 20 diabetic patients with a chronic foot ulcer (>8 weeks) ...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2796.2007.01877.x

    authors: Schwegler B,Stumpe KD,Weishaupt D,Strobel K,Spinas GA,von Schulthess GK,Hodler J,Böni T,Donath MY

    更新日期:2008-01-01 00:00:00

  • The rationale for using apoA-I as a clinical marker of cardiovascular risk.

    abstract::An inverse relationship between the concentration of high-density lipoprotein (HDL) cholesterol and the risk of developing cardiovascular is well established. There are several documented functions of HDLs that may contribute to a protective role of these lipoproteins. These include the ability of HDLs to promote the ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2006.01647.x

    authors: Barter PJ,Rye KA

    更新日期:2006-05-01 00:00:00

  • Oral ketoconazole prophylaxis for Candida infections during induction therapy for acute leukaemia in adults: more bacteraemias.

    abstract::We determined whether ketoconazole prophylaxis might reduce Candida colonization and infections in adult patients with acute leukaemia. During first-remission induction therapy 50 patients were treated with 200 mg ketoconazole administered orally daily, while 57 patients received placebo in a double-blind, randomized ...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2796.1992.tb00945.x

    authors: Palmblad J,Lönnqvist B,Carlsson B,Grimfors G,Järnmark M,Lerner R,Ljungman P,Nyström-Rosander C,Petrini B,Oberg G

    更新日期:1992-04-01 00:00:00

  • Old patients with hypertension. A 25-year observational study of a geographically defined population (Dalby), aged 67 years at entry.

    abstract:OBJECTIVES:To evaluate the impact of hypertension and other risk factors on mortality, in particular cardiovascular mortality, in a geographically defined population of elderly subjects. DESIGN:An observational 25-year study of a total population. SETTING:The local health centre in the village of Dalby in southern Sw...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:

    authors: Lidfeldt J,Lanke J,Sundquist J,Lindholm LH

    更新日期:1998-12-01 00:00:00

  • Health, health care utilization and living conditions in foreign-born diabetic patients in southern Sweden.

    abstract:OBJECTIVES:To compare foreign- and Swedish-born diabetic subjects regarding health care utilization, complications, clinical and socio-economic characteristics. DESIGN:Cross-sectional study. SETTING:All known diabetic patients living in six defined primary health care districts. SUBJECTS:Of 1861 identified subjects ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1046/j.1365-2796.1997.00161.x

    authors: Hjelm K,Apelqvist J,Nyberg P,Sundquist J,Isacsson A

    更新日期:1997-08-01 00:00:00

  • Pulsatile insulin infusion and glucose-homeostasis in well-controlled type 1 (insulin-dependent) diabetic patients.

    abstract::Pulsatile, intravenous insulin infusion designed to mimic the portal insulin concentrations that emerge physiologically after a meal, has been postulated to improve glucose tolerance in Type 1 (insulin-dependent) diabetic patients. We studied the effects of insulin pulsing (10 i.v. pulses of human insulin of 0.035 U k...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1989.tb01403.x

    authors: Heinemann L,Sonnenberg GE,Hohmann A,Ritzenhoff A,Berger M,Benn J,Sönksen P,Kelley D,Gerich J,Aoki T

    更新日期:1989-11-01 00:00:00

  • Determinants of longevity: genetic, environmental and medical factors.

    abstract::This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past ce...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2796.1996.d01-2853.x

    authors: Christensen K,Vaupel JW

    更新日期:1996-12-01 00:00:00

  • Risk factor clustering in patients with hypertension and non-insulin-dependent diabetes mellitus. The Skaraborg Hypertension Project.

    abstract:OBJECTIVES:To assess the coexistence of hypertension and diabetes, associations with cardiovascular risk factors and the achievement of current treatment goals. DESIGN:A community-based, cross-sectional, observational study. SETTING:Hypertension and diabetes outpatient clinics in primary health care, Skara, Sweden. ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1046/j.1365-2796.1998.00286.x

    authors: Bøg-Hansen E,Lindblad U,Bengtsson K,Ranstam J,Melander A,Råstam L

    更新日期:1998-03-01 00:00:00

  • Effect of diet intervention on long-term mortality in healthy middle-aged men with combined hyperlipidaemia.

    abstract:OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.0954-6820.2003.01248.x

    authors: Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

    更新日期:2004-01-01 00:00:00

  • Quality of care assessment for people with multimorbidity.

    abstract::Multimorbidity, the simultaneous presence of multiple health conditions in an individual, is an increasingly common phenomenon globally. The systematic assessment of the quality of care delivered to people with multimorbidity will be key to informing the organization of services for meeting their complex needs. Yet, c...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/joim.12881

    authors: Valderas JM,Gangannagaripalli J,Nolte E,Boyd CM,Roland M,Sarria-Santamera A,Jones E,Rijken M

    更新日期:2019-03-01 00:00:00

  • A conceptual time window-based model for the early stratification of trauma patients.

    abstract::Progress in the testing of therapies targeting the immune response following trauma, a leading cause of morbidity and mortality worldwide, has been slow. We propose that the design of interventional trials in trauma would benefit from a scheme or platform that could support the identification and implementation of pro...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.12874

    authors: Lamparello AJ,Namas RA,Constantine G,McKinley TO,Elster E,Vodovotz Y,Billiar TR

    更新日期:2019-07-01 00:00:00

  • Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease.

    abstract:OBJECTIVES:In this study, we explore the associations of decreased thyroid hormone levels with inflammation, wasting and survival in biochemically euthyroid patients with end-stage renal disease (ESRD). DESIGN:After exclusion of 23 patients with thyroid-stimulating hormone (TSH) values outside the normal range (0.1-4....

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2007.01865.x

    authors: Carrero JJ,Qureshi AR,Axelsson J,Yilmaz MI,Rehnmark S,Witt MR,Bárány P,Heimbürger O,Suliman ME,Alvestrand A,Lindholm B,Stenvinkel P

    更新日期:2007-12-01 00:00:00

  • Renal failure due to sulphadiazine in AIDS patients with cerebral toxoplasmosis.

    abstract::Cerebral toxoplasmosis is optimally treated with the combination of high doses of sulphadiazine and pyrimethamine. We described two patients with AIDS treated for cerebral toxoplasmosis who developed renal failure due to sulphadiazine-induced crystalluria. Symptoms and renal failure were rapidly reversed with urine al...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1993.tb00685.x

    authors: Fariñas MC,Echevarría S,Sampedro I,González A,Pérez del Molino A,González-Macías J

    更新日期:1993-04-01 00:00:00