Abstract:
OBJECTIVE:To explore the relation between 25-hydroxyvitamin D deficiency and frailty. Frailty is a multidimensional phenotype that describes declining physical function and a vulnerability to adverse outcomes in the setting of physical stress such as illness or hospitalization. Low serum concentrations of 25-hydroxyvitamin D are known to be associated with multiple chronic diseases such as cardiovascular disease and diabetes, in addition to all cause mortality. DESIGN:Using data from the Third National Health and Nutrition Survey (NHANES III), we evaluated the association between low serum 25-hydroxyvitamin D concentration and frailty, defined according to a set of criteria derived from a definition previously described and validated. SUBJECTS:Nationally representative survey of noninstitutionalized US residents collected between 1988 and 1994. RESULTS:25-Hydroxyvitamin D deficiency, defined as a serum concentration <15 ng mL(-1), was associated with a 3.7-fold increase in the odds of frailty amongst whites and a fourfold increase in the odds of frailty amongst non-whites. This association persisted after sensitivity analyses adjusting for season of the year and latitude of residence, intended to reduce misclassification of persons as 25-hydroxyvitamin D deficient or insufficient. CONCLUSION:Low serum 25-hydroxyvitamin D concentrations are associated with frailty amongst older adults.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Wilhelm-Leen ER,Hall YN,Deboer IH,Chertow GMdoi
10.1111/j.1365-2796.2010.02248.xsubject
Has Abstractpub_date
2010-08-01 00:00:00pages
171-80issue
2eissn
0954-6820issn
1365-2796pii
JIM2248journal_volume
268pub_type
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