Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial.

abstract：:This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases b...

journal_title：Journal of internal medicine

authors： Calderón-Larrañaga A,Vetrano DL,Ferrucci L,Mercer SW,Marengoni A,Onder G,Eriksdotter M,Fratiglioni L

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to identify predictors of weight loss in obese men participating in a 2-year behaviour modification programme. DESIGN:Longitudinal, clinical intervention study of a behaviour modifying weight loss program. SETTING:University Hospital, Stockholm, Sweden. SUBJECTS:Forty-four ...

journal_title：Journal of internal medicine

authors： Näslund E,Andersson I,Degerblad M,Kogner P,Kral JG,Rössner S,Hellström PM

更新日期：2000-10-01 00:00:00

abstract：:Breast cancer is not only increasing in the west but also particularly rapidly in eastern countries where traditionally the incidence has been low. The rise in incidence is mainly related to changes in reproductive patterns and lifestyle. These trends could potentially be reversed by defining women at greatest risk an...

journal_title：Journal of internal medicine

authors： Howell A,Astley S,Warwick J,Stavrinos P,Sahin S,Ingham S,McBurney H,Eckersley B,Harvie M,Wilson M,Beetles U,Warren R,Hufton A,Sergeant J,Newman W,Buchan I,Cuzick J,Evans DG

更新日期：2012-04-01 00:00:00

abstract：:The ground-breaking discovery of genotype-phenotype relationships in hereditary medullary thyroid cancer has greatly facilitated early prophylactic thyroidectomy. Its timing depends not solely on a positive gene test but, more importantly, on the type of the REarranged during Transfection (RET) mutation and its underl...

journal_title：Journal of internal medicine

authors： Machens A,Lorenz K,Dralle H

更新日期：2009-07-01 00:00:00

abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2016-10-01 00:00:00

abstract：:Preliminary experience of the efficacy and safety of a new regenerating system for selective extracorporeal removal of apolipoprotein B-containing lipoproteins is described. Four patients with familial hyperlipoproteinaemia were studied on 10 occasions. A system of two, parallel, dextran sulphate cellulose columns was...

journal_title：Journal of internal medicine

authors： Eriksson M,Berg B,Berglund L,Lantz B,Angelin B

更新日期：1989-01-01 00:00:00

abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

journal_title：Journal of internal medicine

authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjögren's syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL). OBJECTIVES:To pr...

journal_title：Journal of internal medicine

authors： Baldini C,Santini E,Rossi C,Donati V,Solini A

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:The magnitude of cardiovascular risk associated with psoriasis has been debated and the prognostic impact of psoriasis following myocardial infarction (MI) is unknown. Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients with psoriasis following first-time MI. DESIG...

journal_title：Journal of internal medicine

authors： Ahlehoff O,Gislason GH,Lindhardsen J,Olesen JB,Charlot M,Skov L,Torp-Pedersen C,Hansen PR

更新日期：2011-09-01 00:00:00

abstract：:Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaph...

journal_title：Journal of internal medicine

authors： Serini G,Bussolino F,Maione F,Giraudo E

更新日期：2013-02-01 00:00:00

abstract：:There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and rep...

journal_title：Journal of internal medicine

authors： Kirkwood TB

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Small LDL particle size has been shown to be associated with coronary artery disease. However, no previous study has been performed relating LDL particle size to ultrasound measurement of atherosclerosis in hypercholesterolaemic subjects. The main aims of the present study were therefore: (i) to investigate ...

journal_title：Journal of internal medicine

authors： Hulthe J,Wiklund O,Bondjers G,Wikstrand J

更新日期：2000-07-01 00:00:00

abstract：:The introduction of targeted biological therapies has revolutionised the management of immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. Following treatment with these therapies, many patients experience significant improvement...

journal_title：Journal of internal medicine

authors： Isaacs JD,Cutolo M,Keystone EC,Park W,Braun J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Red blood cell distribution width (RDW), a measure of variation in erythrocyte volume, has been associated with several cardiovascular disorders, but the relationship with atrial fibrillation (AF) remains unclear. We investigated the association between RDW and incidence of first hospitalization due to AF in...

journal_title：Journal of internal medicine

authors： Adamsson Eryd S,Borné Y,Melander O,Persson M,Smith JG,Hedblad B,Engström G

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Combinations of inhaled corticosteroids (ICSs) and long-acting β2 -agonists (LABAs) are recommended for patients with moderate and severe chronic obstructive pulmonary disease (COPD). However, it is not known whether different fixed combinations are equally effective. The aim of this study was to investigate...

journal_title：Journal of internal medicine

authors： Larsson K,Janson C,Lisspers K,Jørgensen L,Stratelis G,Telg G,Ställberg B,Johansson G

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult. METHODS:Markers of cardiac stress (B-type natriuretic peptide, BNP) and inflammation (C-reactive protein, white blood cell count, procalcitonin) as well as t...

journal_title：Journal of internal medicine

authors： Christ-Crain M,Breidthardt T,Stolz D,Zobrist K,Bingisser R,Miedinger D,Leuppi J,Tamm M,Mueller B,Mueller C

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To assess the prophylactic efficacy of aspirin and a high-dose antioxidant vitamin combination in patients with peripheral arterial disease (PAD) in terms of reduction of the risk of a first vascular event (myocardial infarction, stroke, vascular death) and critical limb ischaemia. DESIGN:Randomized, placebo...

journal_title：Journal of internal medicine

authors： Critical Leg Ischaemia Prevention Study (CLIPS) Group.,Catalano M,Born G,Peto R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-med...

journal_title：Journal of internal medicine

authors： Holm Nielsen S,Tengryd C,Edsfeldt A,Brix S,Genovese F,Bengtsson E,Karsdal M,Leeming DJ,Nilsson J,Goncalves I

更新日期：2019-01-01 00:00:00

abstract：:Infection of mural thrombus over an area of old myocardial infarct was found in an elderly woman with cholangitis. This case is unique since cholangitis was thought to be the cause of septicaemia and ventricular aneurysm was not present. ...

journal_title：Journal of internal medicine

authors： Cheung A,Choi A

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVES:To evaluate (i) the demineralizing effect of L-thyroxine (LT4) therapy at doses mildly inhibiting serum thyroid stimulating hormone (TSH) in patients with benign nodular goitre; (ii) the efficacy of treatment on nodule size. DESIGN:Cross-sectional study comparing euthyroid women with nodular goitre treated ...

journal_title：Journal of internal medicine

authors： Baldini M,Gallazzi M,Orsatti A,Fossati S,Leonardi P,Cantalamessa L

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated t...

journal_title：Journal of internal medicine

authors： Abbenhardt C,McTiernan A,Alfano CM,Wener MH,Campbell KL,Duggan C,Foster-Schubert KE,Kong A,Toriola AT,Potter JD,Mason C,Xiao L,Blackburn GL,Bain C,Ulrich CM

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To study the relationships between plasma renin activity and metabolic cardiovascular risk factors in patients with essential hypertension. SUBJECTS AND DESIGN:Patients with uncomplicated essential hypertension (n = 36) with a diastolic blood pressure of 95-115 mmHg were studied. Assessment of plasma renin ...

journal_title：Journal of internal medicine

authors： Allikmets K,Parik T,Teesalu R

更新日期：1996-01-01 00:00:00

abstract：:A total of 41 patients with hypertension were identified in a survey of 732 healthy factory workers. Twenty-three of these individuals were receiving antihypertensive medication, whereas 18 cases were newly discovered. Plasma glucose and insulin responses to oral glucose and fasting plasma triglyceride (TG), cholester...

journal_title：Journal of internal medicine

authors： Zavaroni I,Mazza S,Dall'Aglio E,Gasparini P,Passeri M,Reaven GM

更新日期：1992-03-01 00:00:00

abstract：:For nearly a decade since the mapping of the multiple endocrine neoplasia type 1 (MEN1) locus to 11q13 and the suggestion that it is a tumour suppressor gene, efforts have been made to identify the gene responsible for this familial cancer syndrome. Recently, we have identified the MEN1 gene by the positional cloning ...

journal_title：Journal of internal medicine

authors： Guru SC,Manickam P,Crabtree JS,Olufemi SE,Agarwal SK,Debelenko LV

更新日期：1998-06-01 00:00:00

abstract：:Cerebral toxoplasmosis is optimally treated with the combination of high doses of sulphadiazine and pyrimethamine. We described two patients with AIDS treated for cerebral toxoplasmosis who developed renal failure due to sulphadiazine-induced crystalluria. Symptoms and renal failure were rapidly reversed with urine al...

journal_title：Journal of internal medicine

authors： Fariñas MC,Echevarría S,Sampedro I,González A,Pérez del Molino A,González-Macías J

更新日期：1993-04-01 00:00:00

abstract：:Neuroendocrine tumour of the small intestine (SI-NET), formerly known as midgut carcinoid tumour, is the most common small intestinal malignancy. The incidence is rising, with recent reports of 0.67 per 100 000 in the USA and 1.12 per 100 000 in Sweden. SI-NETs often present a challenge in terms of diagnosis and treat...

journal_title：Journal of internal medicine

authors： Stålberg P,Westin G,Thirlwell C

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To test the relationship between physical activity and physical fitness, and the relationship between these variables and the primordial risk factor blood pressure (BP). DESIGN:A cross-sectional study of all Danish pupils in the same grade at 'gymnasium' (the Danish upper secondary school). SETTING:Tests an...

journal_title：Journal of internal medicine

authors： Andersen LB

更新日期：1994-09-01 00:00:00

abstract：:Clonal haematopoiesis results from acquired mutations in haematopoietic stem and progenitor cells (HSPCs). These mutations can confer the HSPC with a competitive advantage, leading to their clonal expansion within the limiting bone marrow niche. This process is often insufficient to produce a haematologic malignancy; ...

journal_title：Journal of internal medicine

authors： Min KD,Kour A,Sano S,Walsh K

更新日期：2020-11-01 00:00:00

abstract：:This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past ce...

journal_title：Journal of internal medicine

authors： Christensen K,Vaupel JW

更新日期：1996-12-01 00:00:00

abstract：:Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'om...

journal_title：Journal of internal medicine

authors： Bergström G,Berglund G,Blomberg A,Brandberg J,Engström G,Engvall J,Eriksson M,de Faire U,Flinck A,Hansson MG,Hedblad B,Hjelmgren O,Janson C,Jernberg T,Johnsson Å,Johansson L,Lind L,Löfdahl CG,Melander O,Östgren CJ,

更新日期：2015-12-01 00:00:00