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LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia.

Abstract：

OBJECTIVES:Small LDL particle size has been shown to be associated with coronary artery disease. However, no previous study has been performed relating LDL particle size to ultrasound measurement of atherosclerosis in hypercholesterolaemic subjects. The main aims of the present study were therefore: (i) to investigate the relationship between intima-media thickness (IMT) of the carotid bulb and LDL particle size in patients with primary hypercholesterolaemia (n = 102) and in matched normocholesterolaemic controls (n = 102); and (ii) to investigate the relationship between plaque occurrence in the carotid and femoral arteries and LDL particle size. LDL particle size was determined by subjecting serum to 2-16% polyacrylamide gradient gel electrophoresis. RESULTS:The results showed that patients with primary hypercholesterolaemia had smaller LDL peak particle size compared with healthy control subjects (P < 0.001 for men, P = 0.006 for women). However, the difference in LDL peak particle size between patients with hypercholesterolaemia and controls disappeared when adjusting for serum triglycerides. There was no association between increasing IMT of the carotid bulb and decreasing LDL peak particle size or between the occurrence of moderate to large plaques in the carotid and femoral arteries and small LDL peak particle size. However, metabolic variables such as serum triglycerides, HDL, blood glucose, body mass index, and also systolic blood pressure were associated with LDL peak particle size. CONCLUSION:The lack of an association between atherosclerosis, as measured by ultrasound, and small LDL particle size in patients with hypercholesterolaemia implies that other risk factors, such as hypercholesterolaemia and high blood pressure, may overshadow any importance of small LDL particle size.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Hulthe J,Wiklund O,Bondjers G,Wikstrand J

doi

10.1046/j.1365-2796.2000.00698.x

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

42-52

issue

eissn

0954-6820

issn

1365-2796

pii

jim698

journal_volume

248

pub_type

杂志文章

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LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia.