当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > The role of microRNA in nutritional control.

The role of microRNA in nutritional control.

Abstract：

:MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar and nuclear RNAs) and various other metabolites. This complexity of control is likely to explain how a relatively small part of the DNA that codes for proteins has enabled the evolution of such complex organisms as mammals. Non-protein-coding DNA is therefore thought to carry the memory of early evolutionary steps that led to progressively complex metabolic controls. Clinically, miRNAs are becoming increasingly important following the recognition that some congenital abnormalities can be traced to defects in miRNA processing. The potential for manipulating metabolism and affecting disease processes by the pharmaceutical or biological targeting of specific miRNA pathways is now being tested. miRNAs are also released into the extracellular milieu after packaging by cells into nano-sized extracellular vesicles. Such vesicles can be taken up by adjacent and possibly more distant cells, thereby allowing coordinated intercellular communication in specific tissues. Extracellular miRNAs found in the blood stream may also serve as novel biomarkers for both diagnosing specific forms of cancer and assessing the likelihood of metastasis, and as powerful prognostic indices for various cancers. Here, we discuss the role of intracellular and extracellular miRNAs in nutritional control of various (patho)physiological processes. In this review, we provide an update of the presentations from the 25th Marabou Symposium (Stockholm, 14-16 June 2013) entitled 'Role of miRNA in health and nutrition', attended by 50 international experts

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Nolte-'t Hoen EN,Van Rooij E,Bushell M,Zhang CY,Dashwood RH,James WP,Harris C,Baltimore D

doi

10.1111/joim.12372

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

99-109

issue

2

eissn

0954-6820

issn

1365-2796

journal_volume

278

pub_type

杂志文章

相关文献

JOURNAL OF INTERNAL MEDICINE文献大全
  • Bone marrow or peripheral blood stem cell transplantation from unrelated donors in adult patients with acute myeloid leukaemia, an Acute Leukaemia Working Party analysis in 2262 patients.

    abstract：BACKGROUND:No survival benefit of using blood stem cells instead of bone marrow (BM) has been shown in matched unrelated donor (MUD) transplantation. DESIGN AND METHODS:In a retrospective registry analysis, we compared the use of blood stem cells (n = 1502) and BM (n = 760) from unrelated donors in patients aged 18-60...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2012.02547.x

    authors： Ringdén O,Labopin M,Beelen DW,Volin L,Ehninger G,Finke J,Greinix HT,Kyrcz-Krzemien S,Bunjes D,Brinch L,Niederwieser D,Arnold R,Mohty M,Rocha V,Acute Leukaemia Working Party of European Group for Blood and Marrow Transplantati

    更新日期：2012-11-01 00:00:00

  • Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC).

    abstract：:In this article, we review the current knowledge of the inherited genetics of epithelial ovarian cancer (EOC) susceptibility and clinical outcome. We focus on recent developments in identifying low-penetrance susceptibility genes and the role of the Ovarian Cancer Association Consortium (OCAC) in these discoveries. Th...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2011.02509.x

    authors： Bolton KL,Ganda C,Berchuck A,Pharaoh PD,Gayther SA

    更新日期：2012-04-01 00:00:00

  • Reversal of apparent AIDS dementia complex following treatment with vitamin B12.

    abstract：:The human immunodeficiency virus (HIV)-associated dementia complex is characterized by difficulties in concentration and memory followed by apathy, social withdrawal and motor dysfunction. Decreased serum vitamin B12 levels occur in up to 20% of patients with acquired immune deficiency syndrome (AIDS) and may adversel...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1993.tb01005.x

    authors： Herzlich BC,Schiano TD

    更新日期：1993-06-01 00:00:00

  • The risk of hip fractures in patients with primary hyperparathyroidism: a population-based cohort study with a follow-up of 19 years.

    abstract：OBJECTIVE:To evaluate primary hyperparathyroidism (HPT) as a risk factor for hip fractures. DESIGN:A population-based, record-linked, prospective study with a mean observation time of 17 years (women) and 16.5 years (men). SETTING:A cohort obtained from a register of hospital admissions in the Uppsala Health Care Reg...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1993.tb01017.x

    authors： Larsson K,Ljunghall S,Krusemo UB,Naessén T,Lindh E,Persson I

    更新日期：1993-12-01 00:00:00

  • Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension.

    abstract：OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1995.tb01158.x

    authors： Morise T,Takeuchi Y,Takeda R

    更新日期：1995-02-01 00:00:00

  • Prevalence of hyperinsulinaemia in patients with high blood pressure.

    abstract：:A total of 41 patients with hypertension were identified in a survey of 732 healthy factory workers. Twenty-three of these individuals were receiving antihypertensive medication, whereas 18 cases were newly discovered. Plasma glucose and insulin responses to oral glucose and fasting plasma triglyceride (TG), cholester...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00529.x

    authors： Zavaroni I,Mazza S,Dall'Aglio E,Gasparini P,Passeri M,Reaven GM

    更新日期：1992-03-01 00:00:00

  • The prevalence of coronary heart disease in the multi-ethnic and high diabetes prevalence population of Mauritius.

    abstract：:The prevalence of coronary heart disease (CHD) was determined in a population survey in Mauritius where the prevalence of non-insulin dependent diabetes and mortality from CHD are amongst the highest in the world. Men and women aged 35-74 years of all major ethnic groups were included: Asian Indians (Hindus and Muslim...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1993.tb00672.x

    authors： Tuomilehto J,Li N,Dowse G,Gareeboo H,Chitson P,Fareed D,Min Z,Alberti KG,Zimmet P

    更新日期：1993-02-01 00:00:00

  • Old patients with hypertension. A 25-year observational study of a geographically defined population (Dalby), aged 67 years at entry.

    abstract：OBJECTIVES:To evaluate the impact of hypertension and other risk factors on mortality, in particular cardiovascular mortality, in a geographically defined population of elderly subjects. DESIGN:An observational 25-year study of a total population. SETTING:The local health centre in the village of Dalby in southern Sw...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：

    authors： Lidfeldt J,Lanke J,Sundquist J,Lindholm LH

    更新日期：1998-12-01 00:00:00

  • Hepatitis C in clinical practice.

    abstract：:Hepatitis C virus infection is now one of the most important causes of chronic liver disease. Primary care physicians play an important role in the diagnosis and initial work-up of patients infected with this virus. Understanding which patients may be at risk is the first step. By understanding the correct use of hepa...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2001.00781.x

    authors： Larson AM,Carithers RL

    更新日期：2001-02-01 00:00:00

  • Chronic mesenteric ischaemia: diagnostic challenges and treatment options.

    abstract：OBJECTIVES:A description of the clinical presentation, diagnostic procedure and mode of therapy in three patients suffering from chronic mesenteric ischaemia. DESIGN AND INTERVENTIONS:In all cases, the diagnosis was made on the basis of abdominal complaints in combination with angiographic findings. The primary treatm...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1995.tb01178.x

    authors： Hoogenberg K,Van Essen LH,Van den Dungen JJ,Limburg AJ,Boeve WJ,Kleibeuker JH

    更新日期：1995-03-01 00:00:00

  • Twenty-five years' experience of prophylactic treatment in severe haemophilia A and B.

    abstract：:In Sweden, prophylactic treatment of boys with severe haemophilia has been practised since 1958 in an attempt to convert the disease from a severe to a milder form. The present study population consisted of 60 severe haemophiliacs (52 A, 8 B), aged 3-32 years. Treatment is started when the boys are 1-2 years of age, t...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00546.x

    authors： Nilsson IM,Berntorp E,Löfqvist T,Pettersson H

    更新日期：1992-07-01 00:00:00

  • Peptide-based multi-agonists: a new paradigm in metabolic pharmacology.

    abstract：:Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health concerns. Available anti-obesity treatments include weight loss pharmacotherapies and bariatric surgery. Whilst surgical interventions typically result in significant and sustained weight loss, available pharmacotherapies are far les...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12837

    authors： Brandt SJ,Müller TD,DiMarchi RD,Tschöp MH,Stemmer K

    更新日期：2018-12-01 00:00:00

  • Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine.

    abstract：BACKGROUND:Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote apoptosis in tumour cells; this could be improved with specific biomarkers of apoptosis for monitoring treatment. We recently observed specific metabolic patterns...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12117

    authors： Halama A,Riesen N,Möller G,Hrabě de Angelis M,Adamski J

    更新日期：2013-11-01 00:00:00

  • Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome.

    abstract：OBJECTIVE:Platelet-activating factor (PAF) is a phospholipid inflammatory mediator which is synthesized by a variety of cells, including monocytes and endothelial cells, and PAF can be retained in activated endothelial cell membranes. Furthermore, PAF-like lipids are produced in other phospholipid membranes as in oxidi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.00570.x

    authors： Wu R,Lemne C,De Faire U,Frostegârd J

    更新日期：1999-10-01 00:00:00

  • Recombinant nematode anticoagulant protein c2 and other inhibitors targeting blood coagulation factor VIIa/tissue factor.

    abstract：:Originally isolated from a haematophagous hookworm, recombinant nematode anticoagulant protein c2 (rNAPc2) is an 85-amino acid protein with potent anticoagulant properties. Unlike conventional anticoagulants that attenuate blood coagulation via inhibition of thrombin or activated factor X (FXa) at the downstream porti...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2003.01224.x

    authors： Lee AY,Vlasuk GP

    更新日期：2003-10-01 00:00:00

  • Rapid Emergency Medicine score: a new prognostic tool for in-hospital mortality in nonsurgical emergency department patients.

    abstract：OBJECTIVES:To evaluate the predictive accuracy of the scoring system Rapid Acute Physiology score (RAPS) in nonsurgical patients attending the emergency department (ED) regarding in-hospital mortality and length of stay in hospital (LOS), and to investigate whether the predictive ability of RAPS could be improved by ex...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2004.01321.x

    authors： Olsson T,Terent A,Lind L

    更新日期：2004-05-01 00:00:00

  • Lipid lowering in severe familial hypercholesterolaemia: efficacy and safety of a new regenerating system for selective apheresis of apolipoprotein B-containing lipoproteins.

    abstract：:Preliminary experience of the efficacy and safety of a new regenerating system for selective extracorporeal removal of apolipoprotein B-containing lipoproteins is described. Four patients with familial hyperlipoproteinaemia were studied on 10 occasions. A system of two, parallel, dextran sulphate cellulose columns was...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1989.tb00032.x

    authors： Eriksson M,Berg B,Berglund L,Lantz B,Angelin B

    更新日期：1989-01-01 00:00:00

  • Influence of protease inhibitor therapy on lipoprotein metabolism.

    abstract：OBJECTIVES:Protease inhibitors are efficient drugs as part of highly active antiretroviral therapy. They have been shown to cause hyper- and dyslipoproteinemia. Since antiretroviral therapy is able to delay disease progression and possibly extend life expectancy in HIV-infected individuals, the precise nature of serum ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.00615.x

    authors： Berthold HK,Parhofer KG,Ritter MM,Addo M,Wasmuth JC,Schliefer K,Spengler U,Rockstroh JK

    更新日期：1999-12-01 00:00:00

  • A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill.

    abstract：:Mutations in the cardiac Na+ channel gene SCN5A are responsible for multiple lethal ventricular arrhythmias including Brugada syndrome and congenital long QT syndrome. Here we report a case of Brugada syndrome with ST elevation in the right precordial and inferior leads accompanied by atrial standstill and spontaneous...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.0954-6820.2003.01247.x

    authors： Takehara N,Makita N,Kawabe J,Sato N,Kawamura Y,Kitabatake A,Kikuchi K

    更新日期：2004-01-01 00:00:00

  • Impact of waist circumference versus adiponectin level on subclinical atherosclerosis: a cross-sectional analysis in a sample from the general population.

    abstract：OBJECTIVE:Waist circumference is a clinical marker of obesity and an established risk factor for cardiovascular (CV) disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, was recently proposed as the missing link between obesity and increased cardiovascular risk. We evaluated waist and adipon...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2009.02192.x

    authors： Holewijn S,den Heijer M,van Tits LJ,Swinkels DW,Stalenhoef AF,de Graaf J

    更新日期：2010-06-01 00:00:00

  • The effect of captopril and metoprolol as monotherapy or combined with bendroflumethiazide on blood lipids.

    abstract：:In a 24-week randomized multicentre single-blind study, including mild to moderate hypertensives free from other diseases, the effect on blood lipids of captopril (n = 51) was studied and compared with that of metoprolol (n = 53). In order to keep the diastolic pressure less than 95 mm Hg, bendroflumethiazide was adde...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1365-2796.1990.tb00129.x

    authors： Foss OP,Jensen EK

    更新日期：1990-02-01 00:00:00

  • The epidemiology of hepatocellular carcinoma in patients with acute intermittent porphyria.

    abstract：OBJECTIVE:To describe the epidemiology, pathogenesis and clinical features of hepatocellular carcinoma (HCC) in patients with acute intermittent porphyria (AIP). DESIGN:A retrospective population-based mortality study. SUBJECTS:All inhabitants who died between 1978-1990 (2122) including 33 with AIP, in two municipali...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1996.21847000.x

    authors： Andersson C,Bjersing L,Lithner F

    更新日期：1996-10-01 00:00:00

  • The emerging role of microRNAs in cardiovascular disease.

    abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12298

    authors： Maegdefessel L

    更新日期：2014-12-01 00:00:00

  • The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies.

    abstract：:The Swedish Twin Registry (STR), which today has developed into a unique resource, was first established in the late 1950s to study the importance of smoking and alcohol consumption on cancer and cardiovascular diseases whilst controlling for genetic propensity to disease. Since that time, the Registry has been expand...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2002.01032.x

    authors： Lichtenstein P,De Faire U,Floderus B,Svartengren M,Svedberg P,Pedersen NL

    更新日期：2002-09-01 00:00:00

  • What else adds to hypertension in predicting stroke? An incident case-referent study.

    abstract：OBJECTIVES:To examine to what extent traditional biomedical risk factors and social factors can predict, separately or jointly, first-ever stroke event, and to explore to what extent other risk factors might add to hypertension/elevated blood pressure as a stroke risk factor. DESIGN:An incident case-referent study. S...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2000.00746.x

    authors： Ohgren B,Weinehall L,Stegmayr B,Boman K,Hallmans G,Wall S

    更新日期：2000-12-01 00:00:00

  • Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency.

    abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,实务指引,评审

    doi：10.1111/joim.12162

    authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

    更新日期：2014-02-01 00:00:00

  • A multimarker risk stratification approach to non-ST elevation acute coronary syndrome: implications of troponin T, CRP, NT pro-BNP and fibrin D-dimer levels.

    abstract：INTRODUCTION:Biomarkers have emerged as interesting predictors of risk in non-ST elevation acute coronary syndromes (non-ST ACS). The aim of this study was to define the utility of the combined measurement of troponin T (TnT), C-reactive protein (CRP), NT pro-brain natriuretic peptide (NT pro-BNP) and D-dimer as biomar...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2007.01871.x

    authors： Tello-Montoliu A,Marín F,Roldán V,Mainar L,López MT,Sogorb F,Vicente V,Lip GY

    更新日期：2007-12-01 00:00:00

  • Strategies for the prevention of senile (type II) osteoporosis: an update.

    abstract：:Hip fractures in the elderly represent a global issue, associated with significant morbidity and mortality. Considering the magnitude of the problem, any substantial reduction in the hip fracture burden depends on prevention. In view of the complex pathogenesis of senile (type II) osteoporosis, preventive strategies s...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1996.427779000.x

    authors： Boonen S,Dequeker J

    更新日期：1996-05-01 00:00:00

  • Hormone replacement therapy in healthy postmenopausal women. Effects on intraplatelet cyclic guanosine monophosphate, plasma endothelin-1 and neopterin.

    abstract：OBJECTIVES:To evaluate beneficial effects of postmenopausal hormone replacement therapy (HRT) on endothelial function, measured as intraplatelet cyclic guanosine monophosphate (cGMP, mediator of nitric oxide), cyclic adenosine monophosphate (cAMP, mediator of prostacyclin) and plasma endothelin-1 (ET-1), and on monocyt...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2796.2000.00613.x

    authors： Anwaar I,Rendell M,Gottsäter A,Lindgärde F,Hulthén UL,Mattiasson I

    更新日期：2000-04-01 00:00:00

  • Reflexogenic neuronal and humoral responses to selective stimulation of low-pressure cardiopulmonary receptors in man.

    abstract：:This study was conducted to determine the relative importance of efferent muscle sympathetic nerve activity (MSA), vasopressin (ADH) and atrial natriuretic peptide (ANP) in the short-term neurohumoral response to moderate changes in low-pressure cardiopulmonary receptor activity. The low-pressure receptors were stimul...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00323.x

    authors： Agewall S,Rhea B,Persson B,Karlberg B,Wallin G,Andersson OK

    更新日期：1991-02-01 00:00:00