Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension.

abstract：:In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates the number of erythrocytes within the circulation to provide adequate tissue oxygenation. EPO also mediates other effects directed towards optimizing oxygen delivery to tissues, e.g. modulating regional blood flow and reducing b...

journal_title：Journal of internal medicine

authors： Brines M,Cerami A

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

journal_title：Journal of internal medicine

authors： Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

journal_title：Journal of internal medicine

authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown. OBJECTIVE:To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season. METHODS:A subcohort of 5002 Swedish women (mean age 68 years), randomly selecte...

journal_title：Journal of internal medicine

authors： Michaëlsson K,Wolk A,Byberg L,Mitchell A,Mallmin H,Melhus H

更新日期：2017-02-01 00:00:00

abstract：AIMS:To test the hypothesis that stroke and systemic embolic events (SEE) in the stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) III and V trials are different between paroxysmal and persistent atrial fibrillation (AF). METHODS:Data analysis from two cohorts of patients enrolled in ...

journal_title：Journal of internal medicine

authors： Lip GY,Frison L,Grind M,SPORTIF Investigators.

更新日期：2008-07-01 00:00:00

abstract：:In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood pressure was in the range 95-120 mmHg were randomly allocated to groups that received either hydrochlorothiazide or metoprolol, or both drugs when the response to one of them was...

journal_title：Journal of internal medicine

authors： Monmany J,Domingo P,Gomez JA,Sanz F,Roca-Cusachs A,Nolla J,Jane F

更新日期：1990-10-01 00:00:00

abstract：:The hypothesis that asymptomatic visual field defects can be found in patients with carotid transient ischaemic attacks (TIA) or minor strokes was tested. Twenty-two consecutive male patients with TIA and 18 patients with minor strokes from the carotid artery territory were examined by perimetry, cerebral computerised...

journal_title：Journal of internal medicine

authors： Falke P,Abela BM Jr,Krakau CE,Lilja B,Lindgärde F,Maly P,Stavenow L

更新日期：1991-06-01 00:00:00

abstract：:This study was conducted to determine the relative importance of efferent muscle sympathetic nerve activity (MSA), vasopressin (ADH) and atrial natriuretic peptide (ANP) in the short-term neurohumoral response to moderate changes in low-pressure cardiopulmonary receptor activity. The low-pressure receptors were stimul...

journal_title：Journal of internal medicine

authors： Agewall S,Rhea B,Persson B,Karlberg B,Wallin G,Andersson OK

更新日期：1991-02-01 00:00:00

abstract：:Two hundred consecutive patients with femoral neck fractures (FNF) and 200 controls matched by age, sex, nursing home residency and number of admissions within the last 2 years, were interviewed about recent drug use. The matching criteria were chosen to achieve case and control groups that were comparable with regard...

journal_title：Journal of internal medicine

authors： Jensen J,Nielsen LH,Lyhne N,Hallas J,Brøsen K,Gram LF

更新日期：1991-01-01 00:00:00

abstract：:We describe a 57-year-old male with hypertrophic obstructive cardiomyopathy and occult blood loss. Septal alcohol ablation reduced the left ventricular outflow tract obstruction and eliminated recurrent bleeding. The case resembles Heyde's syndrome, i.e. the association between occult gastrointestinal bleeding and aor...

journal_title：Journal of internal medicine

authors： Riis Hansen P,Hassager C

更新日期：2003-04-01 00:00:00

abstract：:The past few years have witnessed a major breakthrough in the understanding of the molecular mechanisms and ultrastructural changes behind the development of proteinuria. The discovery of several proteins in the glomerular podocyte and slit diaphragm, where mutations lead to disease, has revealed the importance of thi...

journal_title：Journal of internal medicine

authors： Tryggvason K,Pettersson E

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Platelet-activating factor (PAF) is a phospholipid inflammatory mediator which is synthesized by a variety of cells, including monocytes and endothelial cells, and PAF can be retained in activated endothelial cell membranes. Furthermore, PAF-like lipids are produced in other phospholipid membranes as in oxidi...

journal_title：Journal of internal medicine

authors： Wu R,Lemne C,De Faire U,Frostegârd J

更新日期：1999-10-01 00:00:00

abstract：:Ten adult patients with a severe nephrotic syndrome resistant to conventional immunosuppression were treated with cyclosporin A (CyA) for a mean period of 11 months. CyA was effective in all but two patients, as evaluated by 24-h urine protein excretion and clinical appearance. In general the best effect of CyA was se...

journal_title：Journal of internal medicine

authors： Nyrop M,Olgaard K

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The UKPDS 34 showed that intensive treatment with metformin significantly reduces macrovascular end-points and mortality in individuals with newly diagnosed type 2 diabetes compared with intensive treatment with insulin or sulphonylurea derivatives, despite similar glycaemic control. How this should be expla...

journal_title：Journal of internal medicine

authors： Wulffelé MG,Kooy A,de Zeeuw D,Stehouwer CD,Gansevoort RT

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:To analyse whether there is an association between country of birth in first-generation immigrants and first hospitalization for or death from coronary heart disease (CHD) and to analyse whether this association remains in second-generation immigrants. DESIGN:In this follow-up study, the MigMed database at ...

journal_title：Journal of internal medicine

authors： Sundquist K,Li X

更新日期：2006-04-01 00:00:00

abstract：:A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

journal_title：Journal of internal medicine

authors： Berkman N,Meirow D,Katzir Z,Bar-On H

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:Sunlight exposure of the skin is known to be the most important source of vitamin D. The aims of this study were: (i) to estimate vitamin D status amongst sunlight-deprived individuals (veiled Arab women, veiled ethnic Danish Moslem women and Danish controls); and (ii) through food intake analysis to estimat...

journal_title：Journal of internal medicine

authors： Glerup H,Mikkelsen K,Poulsen L,Hass E,Overbeck S,Thomsen J,Charles P,Eriksen EF

更新日期：2000-02-01 00:00:00

abstract：:Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in th...

journal_title：Journal of internal medicine

authors： Capitini CM,Chisti AA,Mackall CL

更新日期：2009-08-01 00:00:00

abstract：:A five-year follow-up, by means of a personal interview, was performed on patients below the age of 40 years with acute chest pain without obvious organic cause (n = 64). They had been consecutively admitted to the emergency unit over a period of 8 weeks, and had all been subjected to a thorough medical and psychosoci...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1992-01-01 00:00:00

abstract：:An inverse relationship between the concentration of high-density lipoprotein (HDL) cholesterol and the risk of developing cardiovascular is well established. There are several documented functions of HDLs that may contribute to a protective role of these lipoproteins. These include the ability of HDLs to promote the ...

journal_title：Journal of internal medicine

authors： Barter PJ,Rye KA

更新日期：2006-05-01 00:00:00

abstract：:During the course of an inflammatory process in the thoracic part of the spinal cord, a previously healthy male suffered two myocardial infarctions in separate coronary territories. A coronary angiogram revealed only minor wall changes in one coronary artery. We hypothesize that the myocardial infarctions may have bee...

journal_title：Journal of internal medicine

authors： Lappegård KT,Justad G,Prytz JF,Manhenke C

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk predi...

journal_title：Journal of internal medicine

authors： Kleber ME,Goliasch G,Grammer TB,Pilz S,Tomaschitz A,Silbernagel G,Maurer G,März W,Niessner A

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the association between the proximal level of the clot and the severity of pulmonary embolism (PE). METHODS:The cohort consisted of 99 consecutive patients with PE diagnosed by multi-detector computed tomography. A new score was constructed by calculating the mean val...

journal_title：Journal of internal medicine

authors： Ghanima W,Abdelnoor M,Holmen LO,Nielssen BE,Sandset PM

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine if an acute nicotine infusion alters insulin sensitivity to a similar degree in type 2 diabetic patients as in healthy control subjects. DESIGN:. Double-blind, cross-over, placebo-controlled, randomized experimental study. Nicotine 0.3 microg kg-1 min(-1) or NaCl was inf...

journal_title：Journal of internal medicine

authors： Axelsson T,Jansson PA,Smith U,Eliasson B

更新日期：2001-06-01 00:00:00

abstract：:The fight against doping in sports commenced as a result of the death of a Danish cyclist during the Rome Olympic Games in 1960. The International Olympic Committee (IOC) established a Medical Commission (IOC-MC) which had the task of designing a strategy to combat the misuse of drugs in Olympic Sport. Some Internatio...

journal_title：Journal of internal medicine

authors： Catlin DH,Fitch KD,Ljungqvist A

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:We hypothesized that low presenting systolic blood pressure (SBP) predicted cardioembolic stroke aetiology. DESIGN:Active and passive surveillance were used to identify all ischaemic strokes as part of the Brain Attack Surveillance in Corpus Christi (BASIC) population-based study. Multinomial logistic regres...

journal_title：Journal of internal medicine

authors： Meurer WJ,Sánchez BN,Smith MA,Lisabeth LD,Majersik JJ,Brown DL,Uchino K,Bonikowski FP,Mendizabal JE,Zahuranec DB,Morgenstern LB

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL) in chronic heart failure (HF) of ischaemic aetiology. BACKGROUND:Neutrophil gelatinase-associated lipocalin is a marker of kidney injury as well as matrix degradation and inflammation and has previously been shown to be increa...

journal_title：Journal of internal medicine

authors： Nymo SH,Ueland T,Askevold ET,Flo TH,Kjekshus J,Hulthe J,Wikstrand J,McMurray J,Van Veldhuisen DJ,Gullestad L,Aukrust P,Yndestad A

更新日期：2012-05-01 00:00:00

abstract：:Hepatitis C virus infection is now one of the most important causes of chronic liver disease. Primary care physicians play an important role in the diagnosis and initial work-up of patients infected with this virus. Understanding which patients may be at risk is the first step. By understanding the correct use of hepa...

journal_title：Journal of internal medicine

authors： Larson AM,Carithers RL

更新日期：2001-02-01 00:00:00

abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...

journal_title：Journal of internal medicine

authors： Segal AW

更新日期：2019-10-01 00:00:00

abstract：:Orthostatic hypotension (OH) is a relatively common heterogenous and multifactorial disorder, traditionally classified as neurogenic (less common but often more severe) or nonneurogenic (more common, with no direct signs of autonomic nervous system disease). The different clinical variants of orthostatic intolerance i...

journal_title：Journal of internal medicine

authors： Fedorowski A,Melander O

更新日期：2013-04-01 00:00:00