Hepatitis C in clinical practice.

abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

journal_title：Journal of internal medicine

authors： Maegdefessel L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Small LDL particle size has been shown to be associated with coronary artery disease. However, no previous study has been performed relating LDL particle size to ultrasound measurement of atherosclerosis in hypercholesterolaemic subjects. The main aims of the present study were therefore: (i) to investigate ...

journal_title：Journal of internal medicine

authors： Hulthe J,Wiklund O,Bondjers G,Wikstrand J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Bile acid (BA) synthesis is essential in cholesterol and lipid homoeostasis. METHODS:Serum samples from 435 normal and 23 cholecystectomized subjects were obtained after overnight fasting and assayed for markers of BA and cholesterol synthesis, as well as cholesterol absorption. We determined whether BA syn...

journal_title：Journal of internal medicine

authors： Gälman C,Angelin B,Rudling M

更新日期：2011-12-01 00:00:00

abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...

journal_title：Journal of internal medicine

authors： Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:the results of experimental studies suggest that vitamin D deficiency activates the renin-angiotensin system and predisposes to hypertension. Results of previous epidemiological studies investigating the association between 25-hydroxyvitamin D [25(OH)D] status and hypertension have not been consistent, perha...

journal_title：Journal of internal medicine

authors： Burgaz A,Byberg L,Rautiainen S,Orsini N,Håkansson N,Arnlöv J,Sundström J,Lind L,Melhus H,Michaëlsson K,Wolk A

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Hypovitaminosis D, a condition that is highly prevalent in older adults aged 65 years and above, is associated with brain changes and dementia. Given the rapidly accumulating and complex contribution of the literature in the field of vitamin D and cognition, clear guidance is needed for researchers and clini...

journal_title：Journal of internal medicine

authors： Annweiler C,Dursun E,Féron F,Gezen-Ak D,Kalueff AV,Littlejohns T,Llewellyn DJ,Millet P,Scott T,Tucker KL,Yilmazer S,Beauchet O

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to estimate the prevalence of hypertrophic cardiomyopathy (HCM) in 3607 men from the Reykjavik study of 1979-81. Of these, 452 men had an abnormal (group A) and 3155 a normal electrocardiogram. An echocardiographic control group of 128 men was selected from cohorts with a normal electroca...

journal_title：Journal of internal medicine

authors： Agnarsson UT,Hardarson T,Hallgrimsson J,Sigfusson N

更新日期：1992-12-01 00:00:00

abstract：:Originally isolated from a haematophagous hookworm, recombinant nematode anticoagulant protein c2 (rNAPc2) is an 85-amino acid protein with potent anticoagulant properties. Unlike conventional anticoagulants that attenuate blood coagulation via inhibition of thrombin or activated factor X (FXa) at the downstream porti...

journal_title：Journal of internal medicine

authors： Lee AY,Vlasuk GP

更新日期：2003-10-01 00:00:00

abstract：:Calcium is important for bone health. It has been customary to focus on dietary calcium intake, but of central importance for the body needs in the individual patient is the actual calcium absorption. This absorption consists of an active vitamin D-mediated component and a passive diffusional component. A number of di...

journal_title：Journal of internal medicine

authors： Charles P

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown. OBJECTIVE:To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season. METHODS:A subcohort of 5002 Swedish women (mean age 68 years), randomly selecte...

journal_title：Journal of internal medicine

authors： Michaëlsson K,Wolk A,Byberg L,Mitchell A,Mallmin H,Melhus H

更新日期：2017-02-01 00:00:00

abstract：:The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals...

journal_title：Journal of internal medicine

authors： Bouton C

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Heart failure is characterized by chronically increased adenosine levels, which are thought to express a protective anti-heart failure activation of the adenosinergic system. The aim of the study was to assess whether the activation of adenosinergic system in idiopathic dilated cardiomyopathy (IDC) can be mi...

journal_title：Journal of internal medicine

authors： Laghi-Pasini F,Guideri F,Petersen C,Lazzerini PE,Sicari R,Capecchi PL,Picano E

更新日期：2003-12-01 00:00:00

abstract：:This review describes global patterns of tobacco use and the mechanisms by which tobacco use is involved in carcinogenesis. A second part will discuss the association between tobacco use and risk of specific cancer types. Tobacco use has traditionally been a practice of high-income countries, but it has recently been ...

journal_title：Journal of internal medicine

authors： Kuper H,Adami HO,Boffetta P

更新日期：2002-06-01 00:00:00

abstract：:In the clinic, obesity and anorexia constitute prevalent problems whose manifestations are encountered in virtually every field of medicine. However, as the command centre for regulating food intake and energy metabolism is located in the brain, the basic neuroscientist sees in the same disorders malfunctions of a mod...

journal_title：Journal of internal medicine

authors： Broberger C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Patients with venous thromboembolism (VTE) secondary to transient risk factors may develop VTE recurrences after discontinuing anticoagulation. Identifying at-risk patients could help to guide the duration of therapy. METHODS:We used the RIETE database to assess the prognostic value of d-dimer testing after...

journal_title：Journal of internal medicine

authors： Avnery O,Martin M,Bura-Riviere A,Barillari G,Mazzolai L,Mahé I,Marchena PJ,Verhamme P,Monreal M,Ellis MH,RIETE Investigators.

更新日期：2020-01-01 00:00:00

abstract：:A case of a 44-year-old patient with recurrent deep venous thrombosis (DVT) caused by congenital dysgenesis of the inferior vena cava (IVC) in coincidence with heterozygous factor V Leiden mutation is presented. The IVC malformation was a fortuitous finding because the vascular malformation of the collateral draining ...

journal_title：Journal of internal medicine

authors： Schneider JG,Eynatten MV,Dugi KA,Duex M,Nawroth PP

更新日期：2002-09-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance...

journal_title：Journal of internal medicine

authors： Turner AR,Kader AK,Xu J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to identify predictors of weight loss in obese men participating in a 2-year behaviour modification programme. DESIGN:Longitudinal, clinical intervention study of a behaviour modifying weight loss program. SETTING:University Hospital, Stockholm, Sweden. SUBJECTS:Forty-four ...

journal_title：Journal of internal medicine

authors： Näslund E,Andersson I,Degerblad M,Kogner P,Kral JG,Rössner S,Hellström PM

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

journal_title：Journal of internal medicine

authors： Morise T,Takeuchi Y,Takeda R

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:To study the association between postural hypotension and (i) electrolyte levels and (ii) neurohumoral factors in elderly hypertensive patients using diuretics. DESIGN:Cross-sectional study of patients and controls. SETTING:The subjects were gathered from senior citizen clubs or they were referred to the st...

journal_title：Journal of internal medicine

authors： Luutonen S,Neuvonen P,Ruskoaho H,Räihä I,Rajala T,Antila K,Sourander L

更新日期：1995-04-01 00:00:00

abstract：:A five-year follow-up, by means of a personal interview, was performed on patients below the age of 40 years with acute chest pain without obvious organic cause (n = 64). They had been consecutively admitted to the emergency unit over a period of 8 weeks, and had all been subjected to a thorough medical and psychosoci...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The aims of the study were (i) to examine which antithrombotic therapy patients with known atrial fibrillation use at the point of time when they suffer an ischaemic stroke, (ii) to evaluate the effects of optimal antithrombotic treatment on outcome and severity of the stroke. METHODS:Patients with known at...

journal_title：Journal of internal medicine

authors： Indredavik B,Rohweder G,Lydersen S

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:To assess the clinical course of renal function in relation to risk factors in NIDDM patients with normo- and microalbuminuria. DESIGN:Prospective clinical study. SETTING:Outpatient diabetic clinic. SUBJECTS:Thirty-two NIDDM patients with normo- or microalbuminuria followed for (mean (range)) 5.5 (3.3-7.5...

journal_title：Journal of internal medicine

authors： Nielsen S,Schmitz A,Rehling M,Mogensen CE

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To analyse the associations between serum gamma-glutamyl transpeptidase activity (GTP) and the components of the metabolic syndrome. DESIGN:Cross-sectional, observational study of hypertensive patients and controls. SETTING:The participating subjects visited the research laboratory of the Department of Inte...

journal_title：Journal of internal medicine

authors： Rantala AO,Lilja M,Kauma H,Savolainen MJ,Reunanen A,Kesäniemi YA

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients. DESIGN AND SETTING:This double-blind randomised placebo-controlled trial was performed at the dialysis department of...

journal_title：Journal of internal medicine

authors： Diepeveen SH,Verhoeven GW,Van Der Palen J,Dikkeschei LD,Van Tits LJ,Kolsters G,Offerman JJ,Bilo HJ,Stalenhoef AF

更新日期：2005-05-01 00:00:00

abstract：:Cardiac pheochromocytoma is a rare tumour and may be difficult to localize. We present a 32-year-old male with a cardiac pheochromocytoma that was successfully resected. An initial unenhanced CT did not reveal the tumour. MIBG-scintigraphy indicated the location, but to get full information, a dynamic contrast-enhance...

journal_title：Journal of internal medicine

authors： Jönsson A,Hallengren B,Manhem P,Lilja B,Stavenow L,Ståhl E,Törnquist C

更新日期：1994-07-01 00:00:00

abstract：:Millions of people worldwide receive agents targeting the renin-angiotensin system (RAS) to treat hypertension or statins to lower cholesterol. The RAS and cholesterol metabolic pathways in the brain are autonomous from their systemic counterparts and are interrelated through the cholesterol metabolite 27-hydroxychole...

journal_title：Journal of internal medicine

authors： Petek B,Villa-Lopez M,Loera-Valencia R,Gerenu G,Winblad B,Kramberger MG,Ismail MA,Eriksdotter M,Garcia-Ptacek S

更新日期：2018-12-01 00:00:00

abstract：:Coronary heart disease (CHD) has its origin in childhood. High cholesterol levels measured in children and adolescents are indicative of concurrent atherosclerotic changes and probably predict adult coronary heart disease. We review here the relevance of screening children, adolescents or young adults for serum lipid ...

journal_title：Journal of internal medicine

authors： Porkka KV,Viikari JS

更新日期：1994-08-01 00:00:00

abstract：:As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer st...

journal_title：Journal of internal medicine

authors： Sutlu T,Alici E

更新日期：2009-08-01 00:00:00

abstract：:Gene mutations at the low density lipoprotein (LDL) receptor locus were screened in 210 alleles of Japanese patients with familial hypercholesterolaemia (FH). In the present study, two types of novel mutation were identified by genomic Southern blotting using human LDL receptor cDNA probes. An approximately 12 kb dele...

journal_title：Journal of internal medicine

authors： Kajinami K,Mabuchi H,Inazu A,Fujita H,Koizumi J,Takeda R,Matsue T,Kibata M

更新日期：1990-04-01 00:00:00