当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > Elemental diet: a therapeutic approach in chronic inflammatory bowel disease.

Elemental diet: a therapeutic approach in chronic inflammatory bowel disease.

Abstract：

:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volunteers was executed to investigate palatability of the two diets. The patients were randomized in a double-blind study to the two diet regimes for 14 d. A simultaneous determination of laboratory data including plasma C3c split product and urinary excretion of 51Cr-EDTA was carried out together with a careful registration of the clinical symptoms and signs. No significant effect on the stage of clinical activity was seen in CD. A significant effect on clinical activity was obtained in both UC groups. The clinical improvement was primarily due to a decrease in number of bowel movements both in the elemental diet group and in the group of patients on the blended normal diet. The gross appearance of rectal mucosa did not improve during the study period in the Pepti 2000 or in the placebo group. The concentration of complement split products in plasma remained unchanged. 51Cr-EDTA excretion, as an expression of a leaky bowel mucosa, also remained unchanged. It was concluded that an effect on inflammation could not be demonstrated even if both diets seem to have a beneficial effect on the stage of clinical activity, especially diarrhoea, in patients with UC.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

doi

10.1111/j.1365-2796.1989.tb00089.x

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

325-31

issue

5

eissn

0954-6820

issn

1365-2796

journal_volume

225

pub_type

临床试验,杂志文章,随机对照试验

相关文献

JOURNAL OF INTERNAL MEDICINE文献大全
  • Pseudoxanthoma Elasticum overlaps Hereditary Spastic Paraplegia Type 56.

    abstract：PURPOSE:Pseudoxanthoma elasticum (PXE) is a recessive disorder involving skin, eyes and arteries, mainly caused by ABCC6 pathogenic variants. However, almost one fifth of patients remain genetically unsolved despite extensive genetic screening of ABCC6, as illustrated in a large French PXE series of 220 cases. We searc...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.13193

    authors： Legrand A,Pujol C,Durand CM,Mesnil A,Rubera I,Duranton C,Zuily S,Sousa AB,Renaud M,Boucher JL,Pietrancosta N,Adham S,Orssaud C,Marelli C,Casali C,Ziccardi L,Villain N,Ewenczyk C,Durr A,Mignot C,Stevanin G,Billon

    更新日期：2020-10-27 00:00:00

  • Compliance with and efficacy of treatment with pravastatin and cholestyramine: a randomized study on lipid-lowering in primary care.

    abstract：OBJECTIVES:Lipid-lowering drugs as 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors and cholestyramine are effective in reducing cardiovascular morbidity both in primary and secondary prevention. Patient compliance is an important determinant of the outcome of therapy. This study was designed to co...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2796.1998.00294.x

    authors： Eriksson M,Hådell K,Holme I,Walldius G,Kjellström T

    更新日期：1998-05-01 00:00:00

  • Neuronal cell replacement in Parkinson's disease.

    abstract：:Transplantation of foetal dopamine neurons into the striatum of Parkinson's disease patients can provide restoration of the dopamine system and alleviate motor deficits. However, cellular replacement is associated with several problems. As with pharmacological treatments, cell therapy can lead to disabling abnormal in...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2009.02155.x

    authors： Hedlund E,Perlmann T

    更新日期：2009-10-01 00:00:00

  • The role of microRNA in nutritional control.

    abstract：:MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar a...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12372

    authors： Nolte-'t Hoen EN,Van Rooij E,Bushell M,Zhang CY,Dashwood RH,James WP,Harris C,Baltimore D

    更新日期：2015-08-01 00:00:00

  • Can the course of high dose cotrimoxazole for Pneumocystis carinii pneumonia in AIDS be shorter? A possible solution to the problem of cotrimoxazole toxicity.

    abstract：:Fifty consecutive patients with confirmed PCP received a high dose of cotrimoxazole for 14 d, or until development of intolerance, directly followed by reduced dose maintenance therapy. Seven individuals died during the high dose course. Twenty (47%) of the 43 survivors showed toxicity reactions that necessitated dose...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1990.tb00172.x

    authors： Eeftinck Schattenkerk JK,Lange JM,van Steenwijk RP,Danner SA

    更新日期：1990-05-01 00:00:00

  • Combined effects of obesity and physical activity in predicting mortality among men.

    abstract：OBJECTIVE:We evaluated the hypothesis that higher levels of total daily physical activity can eliminate the increased mortality rate associated with overweight and obesity. DESIGN:Population-based prospective cohort study. SETTING:Central Sweden. SUBJECTS:A total of 37,633 men at baseline 45-79 years of age and free...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2008.01985.x

    authors： Orsini N,Bellocco R,Bottai M,Pagano M,Michaelsson K,Wolk A

    更新日期：2008-11-01 00:00:00

  • Gastrointestinal inflammation: lessons from metabolic modulators.

    abstract：:The link between inflammation and metabolism was apparent already early last century, but has recently been revitalized following molecular studies of atherosclerosis, obesity and insulin resistance. A growing list of nuclear receptors, pivotal players in lipid, xenobiotic and energy metabolism has been identified as ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2008.01964.x

    authors： Arulampalam V

    更新日期：2008-06-01 00:00:00

  • Narrow hips and broad waist circumferences independently contribute to increased risk of non-insulin-dependent diabetes mellitus.

    abstract：OBJECTIVES:Patients with non-insulin-dependent diabetes mellitus (NIDDM) have been shown to be more obese and have higher waist-to-hips circumference ratios compared to nondiabetics. In this study, we tried to dissociate obesity, waist and hip circumference from NIDDM. DESIGN:A cross-sectional population-based case-co...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1997.00235.x

    authors： Seidell JC,Han TS,Feskens EJ,Lean ME

    更新日期：1997-11-01 00:00:00

  • Quality of care assessment for people with multimorbidity.

    abstract：:Multimorbidity, the simultaneous presence of multiple health conditions in an individual, is an increasingly common phenomenon globally. The systematic assessment of the quality of care delivered to people with multimorbidity will be key to informing the organization of services for meeting their complex needs. Yet, c...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12881

    authors： Valderas JM,Gangannagaripalli J,Nolte E,Boyd CM,Roland M,Sarria-Santamera A,Jones E,Rijken M

    更新日期：2019-03-01 00:00:00

  • High D-dimer levels increase the likelihood of pulmonary embolism.

    abstract：:Objective. To determine the utility of high quantitative D-dimer levels in the diagnosis of pulmonary embolism. Methods. D-dimer testing was performed in consecutive patients with suspected pulmonary embolism. We included patients with suspected pulmonary embolism with a high risk for venous thromboembolism, i.e. hosp...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2796.2008.01972.x

    authors： Tick LW,Nijkeuter M,Kramer MH,Hovens MM,Büller HR,Leebeek FW,Huisman MV,Christopher Study Investigators.

    更新日期：2008-08-01 00:00:00

  • Interpretation of data from multiple trials: a critical review.

    abstract：:The objective was to review the current status of meta-analysis, the process of combining the results of similar investigations, which was described in 1976. It has evolved rapidly, and thousands have already been published. Meta-analysis may be performed in a narrative form or in the preferred statistical format, whi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1997.118127000.x

    authors： Conn HO

    更新日期：1997-03-01 00:00:00

  • A patient with osteomalacia as single presenting symptom of gluten-sensitive enteropathy.

    abstract：:A 59-year-old male patient presented with invalidating osteomalacia of 2.5 years' duration. The osteomalacia was caused by severe malabsorption due to gluten-sensitive enteropathy (GSE). There were no other signs or symptoms of GSE in this patient. Clinical presentation with monosymptomatic osteomalacia is very unusua...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00554.x

    authors： De Boer WA,Tytgat GN

    更新日期：1992-07-01 00:00:00

  • Apolipoprotein B48 metabolism in chylomicrons and very low-density lipoproteins and its role in triglyceride transport in normo- and hypertriglyceridemic human subjects.

    abstract：BACKGROUND:Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular disease mandates further exploration of the integrated metabolism of chylomicrons and very low-density lipoproteins (VLDL). METHODS:Novel tracer techniques and an integrated multi-compartmental model were used to determ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.13017

    authors： Björnson E,Packard CJ,Adiels M,Andersson L,Matikainen N,Söderlund S,Kahri J,Hakkarainen A,Lundbom N,Lundbom J,Sihlbom C,Thorsell A,Zhou H,Taskinen MR,Borén J

    更新日期：2020-10-01 00:00:00

  • Bradydysrhythmia-related presyncope secondary to pheochromocytoma.

    abstract：:Pheochromocytoma endures as a life-threatening disorder. In the absence of systemic hypertension, diagnosis may be difficult. We present a 46-year-old normotensive male with a history of presyncope. One of these episodes could be documented, and revealed symptomatic bradycardia suspicious of sinus node arrest. Due to ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1997.00198.x

    authors： Zweiker R,Tiemann M,Eber B,Schumacher M,Fruhwald FM,Lipp R,Lax S,Pristautz H,Klein W

    更新日期：1997-09-01 00:00:00

  • Hyponatraemia in acute brain disease.

    abstract：:Hyponatraemia (HN) can result from a wide range of mechanisms, and therapy must be individualized. Two theories of the origin of HN in acute brain disease have prevailed. The first is the cerebral salt wasting syndrome (CSWS), where excessive natriuresis caused by some unknown cerebral natriuretic factor lowers the to...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.1992.tb00588.x

    authors： Kröll M,Juhler M,Lindholm J

    更新日期：1992-10-01 00:00:00

  • Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score.

    abstract：OBJECTIVE:Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk predi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12189

    authors： Kleber ME,Goliasch G,Grammer TB,Pilz S,Tomaschitz A,Silbernagel G,Maurer G,März W,Niessner A

    更新日期：2014-08-01 00:00:00

  • Prevalence of factor V gene mutation amongst myocardial infarction patients and healthy controls is higher in Sweden than in other countries.

    abstract：OBJECTIVE:Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding fo...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1996.470808000.x

    authors： Holm J,Zöller B,Berntorp E,Erhardt L,Dahlbäck B

    更新日期：1996-03-01 00:00:00

  • Multiple myeloma and chronic myelomonocytic leukaemia developing in a patient with autoimmune disease.

    abstract：:A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00457.x

    authors： Habashi HM,Sharp RA,Pippard MJ

    更新日期：1991-10-01 00:00:00

  • Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTc-MOAB.

    abstract：AIM:Prevalence, optimal diagnostic approach and consequences of clinically unsuspected osteomyelitis in diabetic foot ulcers are unclear. Early diagnosis of this infection may be crucial to ensure correct management. METHODS:We conducted a prospective study in 20 diabetic patients with a chronic foot ulcer (>8 weeks) ...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2796.2007.01877.x

    authors： Schwegler B,Stumpe KD,Weishaupt D,Strobel K,Spinas GA,von Schulthess GK,Hodler J,Böni T,Donath MY

    更新日期：2008-01-01 00:00:00

  • Prednisolone in the treatment of severe malignant hypercalcaemia in metastatic breast cancer: a randomized study.

    abstract：:To determine the effect of prednisolone on severe hypercalcaemia in women with metastatic breast cancer, 30 patients with serum ionized calcium above 1.60 mmol l-1 (reference range 1.15-1.35 mmol l-1) entered a randomized trial. Performance status before entry to the trial and survival time after hypercalcaemia were a...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2796.1992.tb00578.x

    authors： Kristensen B,Ejlertsen B,Holmegaard SN,Krarup-Hansen A,Transbøl I,Mouridsen H

    更新日期：1992-09-01 00:00:00

  • The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.

    abstract：OBJECTIVE:To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL) in chronic heart failure (HF) of ischaemic aetiology. BACKGROUND:Neutrophil gelatinase-associated lipocalin is a marker of kidney injury as well as matrix degradation and inflammation and has previously been shown to be increa...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2796.2011.02503.x

    authors： Nymo SH,Ueland T,Askevold ET,Flo TH,Kjekshus J,Hulthe J,Wikstrand J,McMurray J,Van Veldhuisen DJ,Gullestad L,Aukrust P,Yndestad A

    更新日期：2012-05-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma.

    abstract：:Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, inc...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1993.tb00765.x

    authors： Wetzler M,Estrov Z,Talpaz M,Markowitz A,Gutterman JU,Kurzrock R

    更新日期：1993-10-01 00:00:00

  • Twins and the mystery of missing heritability: the contribution of gene-environment interactions.

    abstract：:Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic var...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2012.02587.x

    authors： Kaprio J

    更新日期：2012-11-01 00:00:00

  • Rapid and correct diagnosis of myocardial infarction: standardized case history and clinical examination provide important information for correct referral to monitored beds.

    abstract：:The value of thorough examination of the case history as a diagnostic tool on hospitalization of patients with suspected myocardial infarction was investigated in three independent prospective studies. Use of a limited number of pain-related elements (= 'criteria'), that had already been obtained in the emergency room...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00322.x

    authors： Jonsbu J,Rollag A,Aase O,Lippestad CT,Arnesen KE,Erikssen J,Koss A

    更新日期：1991-02-01 00:00:00

  • High rate of nonspecific anti-hepatitis C reactivity amongst homosexual men in comparison with that found in other sexually active groups and blood donors. Viral Hepatitis and AIDS Study Group.

    abstract：OBJECTIVES:To investigate the concordance of anti-hepatitis C virus (anti-HCV) reactivity by a second-generation enzyme immunoassay (EIA-2) and by a four-antigen recombinant immunoblot assay (4-RIBA) in homosexual men, in comparison with that found in other sexually active groups and blood donors. DESIGN:Prospective s...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1994.tb01122.x

    authors： Andreu J,Abad MA,Sanchez-Quijano A,Torronteras R,Luque F,Garcia de las Heras J,Soto B,Pineda JA,Leal M,Lissen E

    更新日期：1994-07-01 00:00:00

  • Frequency and effect of optimal anticoagulation before onset of ischaemic stroke in patients with known atrial fibrillation.

    abstract：BACKGROUND:The aims of the study were (i) to examine which antithrombotic therapy patients with known atrial fibrillation use at the point of time when they suffer an ischaemic stroke, (ii) to evaluate the effects of optimal antithrombotic treatment on outcome and severity of the stroke. METHODS:Patients with known at...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2005.01512.x

    authors： Indredavik B,Rohweder G,Lydersen S

    更新日期：2005-08-01 00:00:00

  • Plasma ionized calcium and cardiovascular risk factors in mild primary hyperparathyroidism: effects of long-term treatment with active vitamin D (alphacalcidol).

    abstract：:Primary hyperparathyroidism (HPT) has been associated with hypertension, hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. In the present study, plasma ionized calcium (Ca2+) was studied in relation to cardiovascular risk factors in 20 subjects with mild hypertension. Plasma Ca2+ was found to be negatively ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00955.x

    authors： Lind L,Wengle B,Lithell H,Ljunghall S

    更新日期：1992-04-01 00:00:00

  • What else adds to hypertension in predicting stroke? An incident case-referent study.

    abstract：OBJECTIVES:To examine to what extent traditional biomedical risk factors and social factors can predict, separately or jointly, first-ever stroke event, and to explore to what extent other risk factors might add to hypertension/elevated blood pressure as a stroke risk factor. DESIGN:An incident case-referent study. S...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2000.00746.x

    authors： Ohgren B,Weinehall L,Stegmayr B,Boman K,Hallmans G,Wall S

    更新日期：2000-12-01 00:00:00

  • The genetical history of humans and the great apes.

    abstract：:When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2002.00907.x

    authors： Kaessmann H,Pääbo S

    更新日期：2002-01-01 00:00:00

  • Autoimmunity and extranodal lymphocytic infiltrates in lymphoproliferative disorders.

    abstract：OBJECTIVE:To examine the relationship between autoimmunity and extranodal lymphocytic infiltrates in different lymphoproliferative disorders with immunoglobulin alterations. SUBJECTS AND DESIGN:A clinical review combined with a retrospective cohort study of 380 patients, 28 with monoclonal gammopathy of undetermined s...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.0443f.x

    authors： Jønsson V,Wiik A,Hou-Jensen K,Christiansen M,Ryder LP,Madsen HO,Geisler C,Hansen MM,Thomsen K,Vorstrup S,Svejgaard A

    更新日期：1999-03-01 00:00:00