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Prevalence of factor V gene mutation amongst myocardial infarction patients and healthy controls is higher in Sweden than in other countries.

Abstract：

OBJECTIVE:Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding for coagulation factor V (FV:Q506). To test the importance of the FV:Q506 mutation in premature myocardial infarction (MI), its prevalence was investigated in Swedish patients with MI before the age of 50 years. DESIGN, SETTING AND SUBJECTS:In a retrospective case-control study, the FV:Q506 mutation was investigated in 101 survivors of MI (79 men, 22 women) and in 101 healthy sex- and age-matched controls. MAIN OUTCOME MEASURE:The prevalence of FV:Q506 mutation. RESULTS:The FV:Q506 mutation was found in 18% of patients versus 11% of controls (P = 0.16). The mutation was significantly more frequent amongst male patients than amongst controls (23 vs. 10%; P = 0.03), the calculated odds ratio being 2.6 (95% CI, 1.1-6.4). CONCLUSION:The high prevalence of the FV:Q506 mutation found amongst Swedish MI patients, especially amongst men, is noteworthy, and calls for further studies on the outcome of MI in APC-resistant patients. The prevalence of the FV:Q506 mutation in controls is higher than figures reported from other countries, suggesting that at least 10% of the Swedish population are carriers of a congenital prothrombotic disorder.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Holm J,Zöller B,Berntorp E,Erhardt L,Dahlbäck B

doi

10.1046/j.1365-2796.1996.470808000.x

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

221-6

issue

3

eissn

0954-6820

issn

1365-2796

journal_volume

239

pub_type

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