The clinical course of renal function in NIDDM patients with normo- and microalbuminuria.

abstract：:Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular smooth muscle cells, but th...

journal_title：Journal of internal medicine

authors： Bankir L,Bichet DG,Morgenthaler NG

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:Obesity has generally been associated with higher bone density and lower fracture risk. However, weight-related indices of obesity may be related differently to health end-points, compared with fat-related indices (such as body fat distribution and fat mass), as they may capture different dimensions of obesi...

journal_title：Journal of internal medicine

authors： Moayyeri A,Luben RN,Wareham NJ,Khaw KT

更新日期：2012-05-01 00:00:00

abstract：:In a prospective study, the clinicopathological effect of prednisolone was evaluated in six patients with collagenous colitis. Prednisolone was associated with a significant decrease in stool frequency. However, the effect was transitory, since the diarrhoea recurred when prednisolone treatment was discontinued. There...

journal_title：Journal of internal medicine

authors： Sloth H,Bisgaard C,Grove A

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:The effects of atorvastatin, a new synthetic HMG-CoA reductase inhibitor, were investigated in patients with familial hypercholesterolaemia (FH), with high LDLc levels whilst on standard treatment. DESIGN:Open treatment with 40 mg atorvastatin daily for 6 weeks, followed by another 6 weeks with 80 mg atorva...

journal_title：Journal of internal medicine

authors： Hoogerbrugge N

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:It is well known that pulmonary function is associated with all-cause and cardiovascular (CV) death. Less is known about the association between respiratory symptoms and mortality and whether such an association is independent of physical fitness. In this study, we assessed the association of breathlessness ...

journal_title：Journal of internal medicine

authors： Stavem K,Sandvik L,Erikssen J

更新日期：2006-10-01 00:00:00

abstract：:Millions of people worldwide receive agents targeting the renin-angiotensin system (RAS) to treat hypertension or statins to lower cholesterol. The RAS and cholesterol metabolic pathways in the brain are autonomous from their systemic counterparts and are interrelated through the cholesterol metabolite 27-hydroxychole...

journal_title：Journal of internal medicine

authors： Petek B,Villa-Lopez M,Loera-Valencia R,Gerenu G,Winblad B,Kramberger MG,Ismail MA,Eriksdotter M,Garcia-Ptacek S

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:We hypothesized that low presenting systolic blood pressure (SBP) predicted cardioembolic stroke aetiology. DESIGN:Active and passive surveillance were used to identify all ischaemic strokes as part of the Brain Attack Surveillance in Corpus Christi (BASIC) population-based study. Multinomial logistic regres...

journal_title：Journal of internal medicine

authors： Meurer WJ,Sánchez BN,Smith MA,Lisabeth LD,Majersik JJ,Brown DL,Uchino K,Bonikowski FP,Mendizabal JE,Zahuranec DB,Morgenstern LB

更新日期：2009-03-01 00:00:00

abstract：:A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for c...

journal_title：Journal of internal medicine

authors： Björkhem I

更新日期：2006-12-01 00:00:00

abstract：:Hypersensitivity to progesterone is rare, but the occurrence of skin rash in the luteal phase of the menstrual cycle or during pregnancy should alert one to this possibility. The diagnosis can be readily confirmed by intradermal testing and is eminently treatable by ovulation suppression. ...

journal_title：Journal of internal medicine

authors： Teelucksingh S,Edwards CR

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVES:Statins reduce low-density lipoprotein cholesterol (LDL-C) and can raise high-density lipoprotein cholesterol (HDL-C). HDL-bound paraoxonase-1 (PON1) is associated with variations in plasma HDL-C, and may, therefore, contribute to changes of HDL-C during statin therapy. DESIGN:The effects of baseline PON1 s...

journal_title：Journal of internal medicine

authors： Himbergen TM,van Tits LJ,Voorbij HA,de Graaf J,Stalenhoef AF,Roest M

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:To analyse and evaluate current practice of asthma therapy by use of computerized prescription data. DESIGN:Descriptive, non-interventive. SETTING:A pharmacoepidemiological database on computerized refund claims from pharmacies in the Odense region in Denmark. SUBJECTS:Persons aged 20-44, presenting presc...

journal_title：Journal of internal medicine

authors： Hallas J,Hansen NC

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To ascertain whether carotid intraplaque haemorrhage (IH) in patients undergoing carotid artery surgery is a predictor of increased cardiac mortality over a 5.5 year follow-up. DESIGN AND SUBJECTS:Carotid artery plaques were obtained at surgery from 47 consecutive patients (41 men, six women), median age 67 ...

journal_title：Journal of internal medicine

authors： Falke P,Mätzsch T,Sternby NH,Bergqvist D,Stavenow L

更新日期：1995-08-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseas...

journal_title：Journal of internal medicine

authors： de Serres F,Blanco I

更新日期：2014-10-01 00:00:00

abstract：:Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disorder characterized by periodic attacks of fever and inflammation, due to mutations in the gene coding for the TNF type I receptor (TNFRSF1A). A 16-year-old patient with the diagnosis of TRAPS was admitted to hospital ...

journal_title：Journal of internal medicine

authors： Stjernberg-Salmela S,Kivisaari A,Puolakkainen P,Färkkilä M,Kemppainen E,Ranki A,Pettersson T

更新日期：2006-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar a...

journal_title：Journal of internal medicine

authors： Nolte-'t Hoen EN,Van Rooij E,Bushell M,Zhang CY,Dashwood RH,James WP,Harris C,Baltimore D

更新日期：2015-08-01 00:00:00

abstract：:The socio-economic impact of Alzheimer's disease (AD) and other dementias is enormous, and the potential economic challenges ahead are clear given the projected future numbers of individuals with these conditions. Because of the high prevalence and cost of dementia, it is very important to assess any intervention from...

journal_title：Journal of internal medicine

authors： Wimo A,Ballard C,Brayne C,Gauthier S,Handels R,Jones RW,Jonsson L,Khachaturian AS,Kramberger M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. DESIGN:A case-control study nested within a prospective population study. SUBJECTS:The study cases included 441 men 45-64 years old with n...

journal_title：Journal of internal medicine

authors： Reunanen A,Roivainen M,Kleemola M,Saikku P,Leinonen M,Hovi T,Knekt P,Leino A,Aromaa A

更新日期：2002-11-01 00:00:00

abstract：:A 61-year-old female patient, treated for hyperthyroidism with thiamazole, developed a severe maturation arrest in the granulocytic lineage and a total agranulocytosis. Subcutaneous GM-CSF was started immediately and given for 6 days. Bone marrow samples were taken before GM-CSF therapy and on days 3 and 8. An increas...

journal_title：Journal of internal medicine

authors： Björkholm M,Pisa P,Arver S,Beran M

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Addition of assessment of comorbid diseases ('D') and oxygen saturation ('S') to the CRB-65 score has been recommended to improve its accuracy for risk stratification in community-acquired pneumonia (CAP). The aim of this study was to validate the resulting DS-CRB-65 score in a large cohort of patients with ...

journal_title：Journal of internal medicine

authors： Kolditz M,Ewig S,Schütte H,Suttorp N,Welte T,Rohde G,CAPNETZ study group.

更新日期：2015-08-01 00:00:00

abstract：:Two cases of young healthy males presenting with cardiac tamponade and developing clinical adrenal insufficiency within a few weeks are described. On presentation they had a brisk inflammatory response with complement activation. Both had signs of subclinical hepatitis, and both have later shown evidence of thyroid in...

journal_title：Journal of internal medicine

authors： Torfoss D,von de Lippe E,Jacobsen D

更新日期：1997-06-01 00:00:00

abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS:The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence cas...

journal_title：Journal of internal medicine

authors： Thrainsdottir IS,Hardarson T,Thorgeirsson G,Sigvaldason H,Sigfusson N

更新日期：2003-04-01 00:00:00

abstract：:Hypertriglyceridaemia, as defined by fasting triglyceride levels of greater than 2.8 mmol l-1, is a prevalent dyslipoproteinaemia in our population. The underlying pathophysiological mechanisms that result in elevations of plasma triglycerides are heterogeneous and, in most cases, incompletely understood. However, in ...

journal_title：Journal of internal medicine

authors： Fojo SS,Brewer HB

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Hypertension is an important risk factor for cardiovascular disease. The latest guidelines recommend regular physical exercise as initial step or adjunct in the treatment of hypertension. We investigated the association between physical activity and the degree of hypertension, as well as the relation to indi...

journal_title：Journal of internal medicine

authors： Felmeden DC,Spencer CG,Blann AD,Beevers DG,Lip GY

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:We evaluated the hypothesis that higher levels of total daily physical activity can eliminate the increased mortality rate associated with overweight and obesity. DESIGN:Population-based prospective cohort study. SETTING:Central Sweden. SUBJECTS:A total of 37,633 men at baseline 45-79 years of age and free...

journal_title：Journal of internal medicine

authors： Orsini N,Bellocco R,Bottai M,Pagano M,Michaelsson K,Wolk A

更新日期：2008-11-01 00:00:00

abstract：:Studies of zinc status in insulin-dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B-cell. We therefore prospectively followed 26 patients (14 males and 12 femal...

journal_title：Journal of internal medicine

authors： Melchior T,Simonsen KW,Johannessen AC,Binder C

更新日期：1989-07-01 00:00:00

abstract：:Dysbetalipoproteinaemia is a genetic disorder characterized by accumulation of lipoprotein remnant particles in the plasma, accelerated atherosclerosis, and the abnormal apoprotein E2. Uncontrolled diabetes mellitus can aggravate the hyperlipidaemia associated with this disorder, presumably by increasing triglyceride ...

journal_title：Journal of internal medicine

authors： Duell PB,Bierman EL

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:IgA nephropathy (IgAN) is a common complex disease with a strong genetic involvement. We aimed to identify novel, rare, highly penetrant risk variants combining family-based linkage analysis with whole-exome sequencing (WES). METHODS:Linkage analysis of 16 kindreds of South Italian ancestry was performed us...

journal_title：Journal of internal medicine

authors： Cox SN,Pesce F,El-Sayed Moustafa JS,Sallustio F,Serino G,Kkoufou C,Giampetruzzi A,Ancona N,Falchi M,Schena FP,European IgAN Consortium.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Structural remodelling of left ventricle is a common feature in the progression of congestive heart failure (CHF). Matrix metalloproteinases (MMPs) have been directly implicated as they degrade extracellular proteins. To test the hypothesis that MMP-and its inhibitor, tissue type inhibitor of matrix metallop...

journal_title：Journal of internal medicine

authors： Jordán A,Roldán V,García M,Monmeneu J,de Burgos FG,Lip GY,Marín F

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:A low level of education is associated with an increased risk of developing a dementia disorder, as well as with a higher risk of cardiovascular disease. The aim of this study was to investigate the association between education and cardiovascular risk factors, and to study the relation between these factors...

journal_title：Journal of internal medicine

authors： Kilander L,Nyman H,Boberg M,Lithell H

更新日期：1997-10-01 00:00:00