The seasonal importance of serum 25-hydroxyvitamin D for bone mineral density in older women.


BACKGROUND:The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown. OBJECTIVE:To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season. METHODS:A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003-2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS). RESULTS:In samples collected during summer, we found a gradual increase in BMD of the total hip up to a S-25OHD level of 40 nmol L-1 (6% of the cohort). In women with S-25OHD concentrations below 30 nmol L-1 during summer, adjusted BMD was 11% lower [95% confidence interval (CI) 3-19] and in those with S-25OHD levels of 30-40 nmol L-1 BMD was 6% lower (95% CI 1-11), compared with women with S-25OHD levels above 80 nmol L-1 . Low S-25OHD concentrations during summer (<30 nmol L-1 ) were also associated with higher adjusted relative risk of osteoporosis (4.9; 95% CI 2.9-8.4) compared with concentrations above 80 nmol L-1 . By contrast, no differences in mean BMD values between categories of S-25OHD were found during winter. CONCLUSIONS:Summer concentrations of S-25OHD appear to be the most useful to predict BMD, whereas winter levels have limited value. To determine a S-25OHD cut-off level for vitamin D deficiency, it may be necessary to take into account the season of blood collection.


J Intern Med


Michaëlsson K,Wolk A,Byberg L,Mitchell A,Mallmin H,Melhus H




Has Abstract


2017-02-01 00:00:00












  • Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.

    abstract::Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX are tendon xanthomas, cataracts and progressive neurological dysfunction. Here, we characterize an adult fem...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Hansson M,Olin M,Floren CH,von Bahr S,van't Hooft F,Meaney S,Eggertsen G,Björkhem I

    更新日期:2007-05-01 00:00:00

  • Autoimmune progesterone dermatitis.

    abstract::Hypersensitivity to progesterone is rare, but the occurrence of skin rash in the luteal phase of the menstrual cycle or during pregnancy should alert one to this possibility. The diagnosis can be readily confirmed by intradermal testing and is eminently treatable by ovulation suppression. ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Teelucksingh S,Edwards CR

    更新日期:1990-02-01 00:00:00

  • Utility of genome-wide association study findings: prostate cancer as a translational research paradigm.

    abstract::Genome-wide association studies have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Turner AR,Kader AK,Xu J

    更新日期:2012-04-01 00:00:00

  • Rapid Emergency Medicine score: a new prognostic tool for in-hospital mortality in nonsurgical emergency department patients.

    abstract:OBJECTIVES:To evaluate the predictive accuracy of the scoring system Rapid Acute Physiology score (RAPS) in nonsurgical patients attending the emergency department (ED) regarding in-hospital mortality and length of stay in hospital (LOS), and to investigate whether the predictive ability of RAPS could be improved by ex...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Olsson T,Terent A,Lind L

    更新日期:2004-05-01 00:00:00

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    abstract::There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and rep...

    journal_title:Journal of internal medicine

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    authors: Kirkwood TB

    更新日期:2008-02-01 00:00:00

  • Mucosal T-cell responses to HIV: responding at the front lines.

    abstract::Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanism...

    journal_title:Journal of internal medicine

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    authors: Shacklett BL,Critchfield JW,Ferre AL,Hayes TL

    更新日期:2009-01-01 00:00:00

  • Cardiac pheochromocytoma.

    abstract::Cardiac pheochromocytoma is a rare tumour and may be difficult to localize. We present a 32-year-old male with a cardiac pheochromocytoma that was successfully resected. An initial unenhanced CT did not reveal the tumour. MIBG-scintigraphy indicated the location, but to get full information, a dynamic contrast-enhance...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Jönsson A,Hallengren B,Manhem P,Lilja B,Stavenow L,Ståhl E,Törnquist C

    更新日期:1994-07-01 00:00:00

  • Acute papillary muscle rupture in a patient with clostridial sepsis.

    abstract::We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Schulz R,Andreas S,Weise B,Werner GS

    更新日期:1997-03-01 00:00:00

  • Influence of protease inhibitor therapy on lipoprotein metabolism.

    abstract:OBJECTIVES:Protease inhibitors are efficient drugs as part of highly active antiretroviral therapy. They have been shown to cause hyper- and dyslipoproteinemia. Since antiretroviral therapy is able to delay disease progression and possibly extend life expectancy in HIV-infected individuals, the precise nature of serum ...

    journal_title:Journal of internal medicine

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    authors: Berthold HK,Parhofer KG,Ritter MM,Addo M,Wasmuth JC,Schliefer K,Spengler U,Rockstroh JK

    更新日期:1999-12-01 00:00:00

  • Vaccines modulating lipoprotein autoimmunity as a possible future therapy for cardiovascular disease.

    abstract::Current strategies for prevention of cardiovascular disease focus on risk factor intervention. Although these have been proven both safe and effective results from randomized clinical trials suggest that it is difficult to achieve relative risk reductions exceeding 40% with this approach. To further improve efficacy f...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Nilsson J,Fredrikson GN,Björkbacka H,Chyu KY,Shah PK

    更新日期:2009-09-01 00:00:00

  • Hypoglycaemia caused by atypical insulin antibodies in a patient with benign monoclonal gammopathy.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Arnqvist HJ,Halban PA,Mathiesen UL,Zahnd G,von Schenck H

    更新日期:1993-10-01 00:00:00

  • Hyponatraemia in acute brain disease.

    abstract::Hyponatraemia (HN) can result from a wide range of mechanisms, and therapy must be individualized. Two theories of the origin of HN in acute brain disease have prevailed. The first is the cerebral salt wasting syndrome (CSWS), where excessive natriuresis caused by some unknown cerebral natriuretic factor lowers the to...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Kröll M,Juhler M,Lindholm J

    更新日期:1992-10-01 00:00:00

  • Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study.

    abstract:BACKGROUND:Cigarette smoking has been identified as a major modifiable risk factor for coronary heart disease and mortality. However, findings on the relationship between smoking and atrial fibrillation (AF) have been inconsistent. Furthermore, findings from previous studies were based on self-reported smoking. OBJECT...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Zuo H,Nygård O,Vollset SE,Ueland PM,Ulvik A,Midttun Ø,Meyer K,Igland J,Sulo G,Tell GS

    更新日期:2018-01-01 00:00:00

  • Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women.

    abstract:OBJECTIVES:There is currently widespread exposure to the toxic metal cadmium through the diet as well as through smoking, and it has been suggested that cadmium exposure may increase the risk of cardiovascular disease. Here we examined whether cadmium exposure is associated with prevalence and growth of atherosclerotic...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Fagerberg B,Bergström G,Borén J,Barregard L

    更新日期:2012-12-01 00:00:00

  • Rapid and correct diagnosis of myocardial infarction: standardized case history and clinical examination provide important information for correct referral to monitored beds.

    abstract::The value of thorough examination of the case history as a diagnostic tool on hospitalization of patients with suspected myocardial infarction was investigated in three independent prospective studies. Use of a limited number of pain-related elements (= 'criteria'), that had already been obtained in the emergency room...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Jonsbu J,Rollag A,Aase O,Lippestad CT,Arnesen KE,Erikssen J,Koss A

    更新日期:1991-02-01 00:00:00

  • The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the LIFE study.

    abstract:OBJECTIVES:Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Fossum E,Gleim GW,Kjeldsen SE,Kizer JR,Julius S,Devereux RB,Brady WE,Hille DA,Lyle PA,Dahlöf B

    更新日期:2007-10-01 00:00:00

  • Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Näslund E,Andersson I,Degerblad M,Kogner P,Kral JG,Rössner S,Hellström PM

    更新日期:2000-10-01 00:00:00

  • Hypersensitivity reaction associated with acute hepatic dysfunction following a single intravenous dose of procainamide.

    abstract::Rare cases of hepatotoxicity have been attributed to the antiarrhythmic agent procainamide. We here describe the case of a patient who had a hypersensitivity reaction to procainamide with fever, chills, arthralgia, abdominal pain and acute elevations of serum aminotransferase activities and bilirubin concentration. Th...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Worman HJ,Ip JH,Winters SL,Tepper DC,Gomes AJ

    更新日期:1992-10-01 00:00:00

  • Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. A prospective cohort study.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: de Jong SC,Stehouwer CD,van den Berg M,Geurts TW,Bouter LM,Rauwerda JA

    更新日期:1999-07-01 00:00:00

  • Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Priore Oliva C,Carubbi F,Schaap FG,Bertolini S,Calandra S

    更新日期:2008-04-01 00:00:00

  • Vasopressin: physiology, assessment and osmosensation.

    abstract::Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular smooth muscle cells, but th...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Bankir L,Bichet DG,Morgenthaler NG

    更新日期:2017-10-01 00:00:00

  • No difference in blood thiamine diphosphate levels between Swedish Caucasian patients with congestive heart failure treated with furosemide and patients without heart failure.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Yue QY,Beermann B,Lindström B,Nyquist O

    更新日期:1997-12-01 00:00:00

  • Intra-abdominal abscess in a patient with tumour necrosis factor receptor-associated periodic syndrome.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Stjernberg-Salmela S,Kivisaari A,Puolakkainen P,Färkkilä M,Kemppainen E,Ranki A,Pettersson T

    更新日期:2006-02-01 00:00:00

  • The epidemiology of hepatocellular carcinoma in patients with acute intermittent porphyria.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Andersson C,Bjersing L,Lithner F

    更新日期:1996-10-01 00:00:00

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    authors: Emilsson L,Lindahl B,Köster M,Lambe M,Ludvigsson JF

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Ernst E

    更新日期:1990-06-01 00:00:00

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Riis Hansen P,Hassager C

    更新日期:2003-04-01 00:00:00

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Dullaart RP,Vergeer M,de Vries R,Kappelle PJ,Dallinga-Thie GM

    更新日期:2012-05-01 00:00:00

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Ravn HB,Dørup I

    更新日期:1997-01-01 00:00:00