The seasonal importance of serum 25-hydroxyvitamin D for bone mineral density in older women.

Abstract:

BACKGROUND:The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown. OBJECTIVE:To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season. METHODS:A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003-2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS). RESULTS:In samples collected during summer, we found a gradual increase in BMD of the total hip up to a S-25OHD level of 40 nmol L-1 (6% of the cohort). In women with S-25OHD concentrations below 30 nmol L-1 during summer, adjusted BMD was 11% lower [95% confidence interval (CI) 3-19] and in those with S-25OHD levels of 30-40 nmol L-1 BMD was 6% lower (95% CI 1-11), compared with women with S-25OHD levels above 80 nmol L-1 . Low S-25OHD concentrations during summer (<30 nmol L-1 ) were also associated with higher adjusted relative risk of osteoporosis (4.9; 95% CI 2.9-8.4) compared with concentrations above 80 nmol L-1 . By contrast, no differences in mean BMD values between categories of S-25OHD were found during winter. CONCLUSIONS:Summer concentrations of S-25OHD appear to be the most useful to predict BMD, whereas winter levels have limited value. To determine a S-25OHD cut-off level for vitamin D deficiency, it may be necessary to take into account the season of blood collection.

journal_name

J Intern Med

authors

Michaëlsson K,Wolk A,Byberg L,Mitchell A,Mallmin H,Melhus H

doi

10.1111/joim.12563

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

167-178

issue

2

eissn

0954-6820

issn

1365-2796

journal_volume

281

pub_type

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