当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.

Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.

Abstract：

BACKGROUND:Bile acid (BA) synthesis is essential in cholesterol and lipid homoeostasis. METHODS:Serum samples from 435 normal and 23 cholecystectomized subjects were obtained after overnight fasting and assayed for markers of BA and cholesterol synthesis, as well as cholesterol absorption. We determined whether BA synthesis was related to fibroblast growth factor 19 (FGF19; a circulating metabolic regulator that is thought to inhibit BA synthesis), gender, age and serum lipids. RESULTS:Bile acid synthesis varied more than 9-fold in normal individuals and was 29% higher in men than in women. Whilst low-density lipoprotein cholesterol increased with age, BA and cholesterol synthesis were stable. BA production was positively correlated with serum triglycerides (TGs), and 35% of individuals with a high level (>95th percentile) of BA synthesis had hypertriglyceridaemia (HTG) (>95th percentile). Serum FGF19 levels varied by 7-fold in normal individuals and were related inversely to BA synthesis but were not related to gender, plasma lipids or history of cholecystectomy. CONCLUSIONS:Bile acid synthesis has a wide inter-individual variation, is lower in women than in men and is correlated positively with serum TGs. High BA production is frequently linked to HTG. Age-related hypercholesterolaemia is not associated with changes in BA or cholesterol production, nor to an increase in cholesterol absorption. In humans, the circulating level of FGF19 may regulate hepatic BA production under fasting conditions.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Gälman C,Angelin B,Rudling M

doi

10.1111/j.1365-2796.2011.02466.x

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

580-8

issue

6

eissn

0954-6820

issn

1365-2796

journal_volume

270

pub_type

杂志文章

相关文献

JOURNAL OF INTERNAL MEDICINE文献大全
  • The emerging role of microRNAs in cardiovascular disease.

    abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12298

    authors： Maegdefessel L

    更新日期：2014-12-01 00:00:00

  • Lean mass and physical activity as predictors of bone mineral density in 16-20-year old women.

    abstract：OBJECTIVE:The aim of the study was to quantify the inter-relationship between bone mineral density and physical activity, muscle strength, and body mass composition in a group of healthy 16-20-year-old women. DESIGN:A cross-sectional study. SETTING:Reykjavik area. SUBJECTS:Two-hundred and fifty-four Icelandic Caucas...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.00486.x

    authors： Valdimarsson O,Kristinsson JO,Stefansson SO,Valdimarsson S,Sigurdsson G

    更新日期：1999-05-01 00:00:00

  • Atrial fibrillation or flutter and stroke: a Danish population-based study of the effectiveness of oral anticoagulation in clinical practice.

    abstract：OBJECTIVES:A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2002.01009.x

    authors： Frost L,Johnsen SP,Pedersen L,Toft E,Husted S,Sørensen HT

    更新日期：2002-07-01 00:00:00

  • Two IgM paraproteins bearing cryoglobulin and anti-smooth muscle activities in a patient with Waldenström's macroglobulinaemia.

    abstract：:A 52-year-old white male subject with typical clinical and laboratory findings of Waldenström's macroglobulinaemia is described. Two paraprotein peaks of IgM lambda class, with different physical and chemical properties and different amino acid compositions, in both heavy and light chains, were found in the patient's ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00312.x

    authors： Ruiz-Palomo F,Revilla Y,Gonzales Porque P,Serrano Rios M

    更新日期：1991-01-01 00:00:00

  • Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene.

    abstract：:APOA5 encodes a novel apolipoprotein (apo A-V) which appears to be a modulator of plasma triglyceride (TG). In apoA5 knock out mice plasma TG level increases almost fourfold, whereas in human APOA5 transgenic mice it decreases by 70%. Some SNPs in the APOA5 gene have been associated with variations in plasma TG in hum...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2007.01912.x

    authors： Priore Oliva C,Carubbi F,Schaap FG,Bertolini S,Calandra S

    更新日期：2008-04-01 00:00:00

  • Liver fibrosis attributed to lipid lowering medications: two cases.

    abstract：:We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2001.00848.x

    authors： Punthakee Z,Scully LJ,Guindi MM,Ooi TC

    更新日期：2001-09-01 00:00:00

  • Sheehan's syndrome: differential diagnosis in the acute phase.

    abstract：:Many studies have been done in the later course of Sheehan's syndrome, but very few have documented the acute phase with clinical, endocrine and imaging data. We present the case of a young woman complaining of severe headache after delivery, who developed hypopituitarism. Magnetic resonance imaging (MRI) disclosed th...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1998.00370.x

    authors： Dejager S,Gerber S,Foubert L,Turpin G

    更新日期：1998-09-01 00:00:00

  • Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

    abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12022

    authors： Lewis I,Pairman J,Spickett G,Newton JL

    更新日期：2013-05-01 00:00:00

  • Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease.

    abstract：OBJECTIVES:In this study, we explore the associations of decreased thyroid hormone levels with inflammation, wasting and survival in biochemically euthyroid patients with end-stage renal disease (ESRD). DESIGN:After exclusion of 23 patients with thyroid-stimulating hormone (TSH) values outside the normal range (0.1-4....

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2007.01865.x

    authors： Carrero JJ,Qureshi AR,Axelsson J,Yilmaz MI,Rehnmark S,Witt MR,Bárány P,Heimbürger O,Suliman ME,Alvestrand A,Lindholm B,Stenvinkel P

    更新日期：2007-12-01 00:00:00

  • Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study.

    abstract：OBJECTIVES:Obesity has generally been associated with higher bone density and lower fracture risk. However, weight-related indices of obesity may be related differently to health end-points, compared with fat-related indices (such as body fat distribution and fat mass), as they may capture different dimensions of obesi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2011.02443.x

    authors： Moayyeri A,Luben RN,Wareham NJ,Khaw KT

    更新日期：2012-05-01 00:00:00

  • Multiple endocrine neoplasia type 2 syndromes may be associated with renal malformations.

    abstract：OBJECTIVE:The RET proto-oncogene is known to be the susceptibility gene for various disease phenotypes, including multiple endocrine neoplasia type 2 (MEN 2). Recent studies have also suggested an involvement of RET in the development of the mammalian kidney. Although kidney agenesis or dysgenesis has been observed in ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2001.00846.x

    authors： Loré F,Talidis F,Di Cairano G,Renieri A

    更新日期：2001-07-01 00:00:00

  • Very low level of microalbuminuria is associated with increased risk of death in subjects with cardiovascular or cerebrovascular diseases.

    abstract：BACKGROUND:The original definition of microalbuminuria (20-200 microg min-1 or 15-150 microg min-1 overnight) is based on studies of patients with diabetes, in whom microalbuminuria was associated with increased risk of chronic renal failure. In a recent report an overnight urinary albumin excretion (UAE) above only 5 ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2006.01679.x

    authors： Klausen KP,Scharling H,Jensen JS

    更新日期：2006-09-01 00:00:00

  • Effect of diet intervention on long-term mortality in healthy middle-aged men with combined hyperlipidaemia.

    abstract：OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.0954-6820.2003.01248.x

    authors： Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

    更新日期：2004-01-01 00:00:00

  • Effect of pancreas transplantation on glucose counterregulation in insulin-dependent diabetic patients prone to severe hypoglycaemia.

    abstract：:Pancreatic transplantation was performed in three patients with insulin-dependent diabetes mellitus in whom recurrent and severe episodes of hypoglycaemia had been found to be due to defective glucose counterregulation. Thus in these patients the spontaneous blood glucose recovery after insulin-induced hypoglycaemia (...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00484.x

    authors： Bolinder J,Wahrenberg H,Persson A,Linde B,Tydén G,Groth CG,Ostman J

    更新日期：1991-12-01 00:00:00

  • Intermittent intravenous followed by intermittent oral 1 alpha(OH)D3 treatment of secondary hyperparathyroidism in uraemia.

    abstract：OBJECTIVES:To examine whether intermittent oral 1 alpha(OH)D3 treatment of patients on haemodialysis with secondary hyperparathyroidism (HPT) was able to maintain the marked suppression of PTH, which previously had been induced by an intermittent intravenous administration of 1 alpha(OH)D3. Simultaneously, the effect o...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2796.1996.469810000.x

    authors： Brandi L,Daugaard H,Egsmose C,Tvedegaard E,Kjaerulff Nielsen P,Olgaard K

    更新日期：1996-04-01 00:00:00

  • Understanding ageing from an evolutionary perspective.

    abstract：:There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and rep...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2007.01901.x

    authors： Kirkwood TB

    更新日期：2008-02-01 00:00:00

  • Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

    abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2010.02294.x

    authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

    更新日期：2011-03-01 00:00:00

  • Connecting the brain cholesterol and renin-angiotensin systems: potential role of statins and RAS-modifying medications in dementia.

    abstract：:Millions of people worldwide receive agents targeting the renin-angiotensin system (RAS) to treat hypertension or statins to lower cholesterol. The RAS and cholesterol metabolic pathways in the brain are autonomous from their systemic counterparts and are interrelated through the cholesterol metabolite 27-hydroxychole...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12838

    authors： Petek B,Villa-Lopez M,Loera-Valencia R,Gerenu G,Winblad B,Kramberger MG,Ismail MA,Eriksdotter M,Garcia-Ptacek S

    更新日期：2018-12-01 00:00:00

  • Chronic rhinosinusitis is associated with prolonged SARS-CoV2 RNA shedding in upper respiratory tract samples: A case-control study.

    abstract：BACKGROUND:SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient's basal...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.13237

    authors： Recalde-Zamacona B,Tomás-Velázquez A,Campo A,Satrústegui-Alzugaray B,Fernández-Alonso M,Iñigo M,Rodríguez-Mateos M,Di Frisco M,Felgueroso C,Bertó J,Marín-Oto M,Alcaide AB,Zulueta JJ,Seijo L,Landecho MF

    更新日期：2020-12-29 00:00:00

  • Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response.

    abstract：:In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates the number of erythrocytes within the circulation to provide adequate tissue oxygenation. EPO also mediates other effects directed towards optimizing oxygen delivery to tissues, e.g. modulating regional blood flow and reducing b...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2008.02024.x

    authors： Brines M,Cerami A

    更新日期：2008-11-01 00:00:00

  • Secondary prevention of heart disease amongst patients with lipid abnormalities: practice and trends in the United States.

    abstract：:Patients with established coronary disease and abnormalities of lipid metabolism represent a particularly important subgroup, since their mortality risk is typically 10 times greater than that amongst-subjects with comparable risk factors but no clinical history. Such patients are commonly treated initially with anti-...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1997.109132000.x

    authors： Brown BG,Zhao XQ,Bardsley J,Albers JJ

    更新日期：1997-04-01 00:00:00

  • Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study.

    abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/joim.12052

    authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

    更新日期：2013-07-01 00:00:00

  • Review of 103 Swedish Healthcare Quality Registries.

    abstract：BACKGROUND AND OBJECTIVES:In the past two decades, an increasing number of nationwide, Swedish Healthcare Quality Registries (QRs) focusing on specific disorders have been initiated, mostly by physicians. Here, we describe the purpose, organization, variables, coverage and completeness of 103 Swedish QRs. METHODS:From...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12303

    authors： Emilsson L,Lindahl B,Köster M,Lambe M,Ludvigsson JF

    更新日期：2015-01-01 00:00:00

  • Novel gene mutations at the low density lipoprotein receptor locus: FH-Kanazawa and FH-Okayama.

    abstract：:Gene mutations at the low density lipoprotein (LDL) receptor locus were screened in 210 alleles of Japanese patients with familial hypercholesterolaemia (FH). In the present study, two types of novel mutation were identified by genomic Southern blotting using human LDL receptor cDNA probes. An approximately 12 kb dele...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1990.tb00153.x

    authors： Kajinami K,Mabuchi H,Inazu A,Fujita H,Koizumi J,Takeda R,Matsue T,Kibata M

    更新日期：1990-04-01 00:00:00

  • Effects of atorvastatin on serum lipids of patients with familial hypercholesterolaemia.

    abstract：OBJECTIVES:The effects of atorvastatin, a new synthetic HMG-CoA reductase inhibitor, were investigated in patients with familial hypercholesterolaemia (FH), with high LDLc levels whilst on standard treatment. DESIGN:Open treatment with 40 mg atorvastatin daily for 6 weeks, followed by another 6 weeks with 80 mg atorva...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2796.1998.00352.x

    authors： Hoogerbrugge N

    更新日期：1998-08-01 00:00:00

  • Low frequency of the common Norwegian and Finnish LDL-receptor mutations in Swedish patients with familial hypercholesterolaemia.

    abstract：OBJECTIVE:To evaluate the frequency of the common Finnish and Norwegian mutations in the low density lipoprotein (LDL) receptor gene in Swedish patients with familial hypercholesterolaemia (FH), and to start screening for other mutations in these patients. In contrast to the situation in Norway and Finland, where the f...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1998.00309.x

    authors： Lind S,Eriksson M,Rystedt E,Wiklund O,Angelin B,Eggertsen G

    更新日期：1998-07-01 00:00:00

  • The origins of the developmental origins theory.

    abstract：:Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-u...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2007.01809.x

    authors： Barker DJ

    更新日期：2007-05-01 00:00:00

  • Spinal tuberculosis: overlooked?

    abstract：OBJECTIVE:The aim of the present study was to ascertain the degree of occurrence of tuberculous infection in patients presenting with low back pain (LBP). METHODS:Forty consecutive patients seeking primary medical attention for the main symptom of LBP and presenting to the Rheumatology Outpatient Clinic of our institu...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2006.01675.x

    authors： Abou-Raya S,Abou-Raya A

    更新日期：2006-08-01 00:00:00

  • Treatment with anti-inflammatory drugs in community-acquired pneumonia.

    abstract：:Pneumonia exhibits a broad range of severity, from mildly symptomatic at one end to fulminant septic shock and death at the other. Although an adequate inflammatory response is necessary for the clearance of microorganisms, excessive inflammation can lead to ongoing local and systemic damage. Because of this extended ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2012.02554.x

    authors： Meijvis SC,van de Garde EM,Rijkers GT,Bos WJ

    更新日期：2012-07-01 00:00:00

  • Clinical characteristics and predictors of the duration of SARS-CoV-2 viral shedding in 140 healthcare workers.

    abstract：BACKGROUND:Epidemiological and clinical features of patients with COVID-19 have been reported, but none of them focused on medical staff, and few predictors of the duration of viral shedding have been reported. It is urgent to help healthcare workers prevent and recover quickly from the coronavirus disease 2019 (COVID-...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.13160

    authors： Liu W,Liu Y,Xu Z,Jiang T,Kang Y,Zhu G,Chen Z

    更新日期：2020-12-01 00:00:00