当前位置： SCI文献检索 > JOURNAL OF INTERNAL MEDICINE期刊下所有文献 > Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis.

Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis.

Abstract：

OBJECTIVES:Hypocitraturia is a risk factor for calcium nephrolithiasis. 1,25(OH)2D3 influences renal citrate handling and enhances citraturia. The aim of this study was to evaluate the relationship between vitamin D receptor (VDR) allelic variant and urinary citrate excretion in recurrent stone formers (SF) patients. DESIGN:Case-control study. SUBJECTS:A total of 220 recurrent calcium oxalate SF patients and 114 healthy control (C) subjects were enrolled for this study. Subjects with urinary tract infections, hyperparathyroidism, cystinuria >70 micromol/24 h, gouty diathesis, renal tubular acidosis, renal failure, chronic diarrhoeal states, intake of thiazide diuretics, angiotensin-converting enzyme (ACE)-inhibitors, glucocorticoids or oestrogens were excluded. A standard constant diet was given for 7 days. The 24-h urinary citrate excretion and the active tubular reabsorption of filtered citrate (Rcit) were evaluated. Hypocitraturia was defined as a urinary citrate excretion lower than 1.7 mmol day-1. Stone formers patients and C were genotyped for BsmI and TaqI VDR alleles. Contingency table chi-square tests were used to compare genotype frequencies in hypocitraturic SF patients, normocitraturic SF and C. RESULTS:The prevalence of hypocitraturia in SF patients was 32.7% (72 of 200). Hypocitraturia in these patients resulted from excessive Rcit of a normal load of citrate. We found a different distribution (P < 0.05) of BsmI and TaqI VDR genotypes in hypocitraturic SF patients compared with normocitraturic SF and C. In particular, the prevalence of bb and TT VDR genotypes in hypocitraturic SF was significantly higher than in normocitraturic SF and C. CONCLUSIONS:These results point to a genetic association between BsmI and TaqI VDR polymorphisms and idiopathic hypocitraturia in calcium-oxalate recurrent SF patients.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Mossetti G,Vuotto P,Rendina D,Numis FG,Viceconti R,Giordano F,Cioffi M,Scopacasa F,Nunziata V

doi

10.1046/j.1365-2796.2003.01086.x

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

194-200

issue

2

eissn

0954-6820

issn

1365-2796

pii

1086

journal_volume

253

pub_type

杂志文章

相关文献

JOURNAL OF INTERNAL MEDICINE文献大全
  • Do drug costs affect physicians' prescription decisions?

    abstract：OBJECTIVE:To study the impact of the cost of pharmaceuticals on physicians' decisions about drug prescription. DESIGN:A simulation protocol for the treatment of two patients, one with mild and the other with a severe form of urinary tract infection (UTI), was designed. Thirty family physicians in outpatient clinics an...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1997.137143000.x

    authors： Hart J,Salman H,Bergman M,Neuman V,Rudniki C,Gilenberg D,Matalon A,Djaldetti M

    更新日期：1997-05-01 00:00:00

  • Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies.

    abstract：OBJECTIVES:Autoantibodies to apolipoprotein (apo) B-100 peptides are present in human plasma and have been shown to be associated with decreased cardiovascular risk. The present study aimed to determine if apo B-100 peptide vaccines are atheroprotective in mice expressing human apo B-100 and if the effectiveness of the...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2008.01995.x

    authors： Fredrikson GN,Björkbacka H,Söderberg I,Ljungcrantz I,Nilsson J

    更新日期：2008-12-01 00:00:00

  • Pathogenic immune mechanisms at the neuromuscular synapse: the role of specific antibody-binding epitopes in myasthenia gravis.

    abstract：:Autoantibodies against three different postsynaptic antigens and one presynaptic antigen at the neuromuscular junction are known to cause myasthenic syndromes. The mechanisms by which these antibodies cause muscle weakness vary from antigenic modulation and complement-mediated membrane damage to inhibition of endogeno...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12163

    authors： Huijbers MG,Lipka AF,Plomp JJ,Niks EH,van der Maarel SM,Verschuuren JJ

    更新日期：2014-01-01 00:00:00

  • HIV infection and bone disease.

    abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12520

    authors： Compston J

    更新日期：2016-10-01 00:00:00

  • Autoimmunity and extranodal lymphocytic infiltrates in lymphoproliferative disorders.

    abstract：OBJECTIVE:To examine the relationship between autoimmunity and extranodal lymphocytic infiltrates in different lymphoproliferative disorders with immunoglobulin alterations. SUBJECTS AND DESIGN:A clinical review combined with a retrospective cohort study of 380 patients, 28 with monoclonal gammopathy of undetermined s...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1999.0443f.x

    authors： Jønsson V,Wiik A,Hou-Jensen K,Christiansen M,Ryder LP,Madsen HO,Geisler C,Hansen MM,Thomsen K,Vorstrup S,Svejgaard A

    更新日期：1999-03-01 00:00:00

  • The origins of the developmental origins theory.

    abstract：:Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-u...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2007.01809.x

    authors： Barker DJ

    更新日期：2007-05-01 00:00:00

  • Hypersensitivity reaction associated with acute hepatic dysfunction following a single intravenous dose of procainamide.

    abstract：:Rare cases of hepatotoxicity have been attributed to the antiarrhythmic agent procainamide. We here describe the case of a patient who had a hypersensitivity reaction to procainamide with fever, chills, arthralgia, abdominal pain and acute elevations of serum aminotransferase activities and bilirubin concentration. Th...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00599.x

    authors： Worman HJ,Ip JH,Winters SL,Tepper DC,Gomes AJ

    更新日期：1992-10-01 00:00:00

  • Cardiac pheochromocytoma.

    abstract：:Cardiac pheochromocytoma is a rare tumour and may be difficult to localize. We present a 32-year-old male with a cardiac pheochromocytoma that was successfully resected. An initial unenhanced CT did not reveal the tumour. MIBG-scintigraphy indicated the location, but to get full information, a dynamic contrast-enhance...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1994.tb01126.x

    authors： Jönsson A,Hallengren B,Manhem P,Lilja B,Stavenow L,Ståhl E,Törnquist C

    更新日期：1994-07-01 00:00:00

  • When to initiate and discontinue biologic treatments for rheumatoid arthritis?

    abstract：:The introduction of biologic therapies heralded a new era in the treatment for chronic inflammatory autoimmune diseases of which rheumatoid arthritis is one of the most prevalent. From a scientific point of view, these therapies demonstrated that the targeting of individual cytokines or cell-surface markers is a very ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.2011.02355.x

    authors： Chatzidionysiou K,van Vollenhoven RF

    更新日期：2011-06-01 00:00:00

  • Twenty-five years' experience of prophylactic treatment in severe haemophilia A and B.

    abstract：:In Sweden, prophylactic treatment of boys with severe haemophilia has been practised since 1958 in an attempt to convert the disease from a severe to a milder form. The present study population consisted of 60 severe haemophiliacs (52 A, 8 B), aged 3-32 years. Treatment is started when the boys are 1-2 years of age, t...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00546.x

    authors： Nilsson IM,Berntorp E,Löfqvist T,Pettersson H

    更新日期：1992-07-01 00:00:00

  • Renal artery embolism: thrombolysis with recombinant tissue-type plasminogen activator.

    abstract：:The case of a patient with acute occlusion of the right renal artery due to an embolus is described. Using transoesophageal echocardiography, the left atrial appendage could be identified as the source of embolism. Twenty hours after the onset of symptoms, the embolus could be successfully dissolved with an intra-arte...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2796.1990.tb00232.x

    authors： Mügge A,Gulba DC,Frei U,Wagenbreth I,Grote R,Daniel WG,Lichtlen PR

    更新日期：1990-09-01 00:00:00

  • Secondary prevention of heart disease amongst patients with lipid abnormalities: practice and trends in the United States.

    abstract：:Patients with established coronary disease and abnormalities of lipid metabolism represent a particularly important subgroup, since their mortality risk is typically 10 times greater than that amongst-subjects with comparable risk factors but no clinical history. Such patients are commonly treated initially with anti-...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1997.109132000.x

    authors： Brown BG,Zhao XQ,Bardsley J,Albers JJ

    更新日期：1997-04-01 00:00:00

  • Blunted increase in plasma adenosine levels following dipyridamole stress in dilated cardiomyopathy patients.

    abstract：BACKGROUND:Heart failure is characterized by chronically increased adenosine levels, which are thought to express a protective anti-heart failure activation of the adenosinergic system. The aim of the study was to assess whether the activation of adenosinergic system in idiopathic dilated cardiomyopathy (IDC) can be mi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2003.01234.x

    authors： Laghi-Pasini F,Guideri F,Petersen C,Lazzerini PE,Sicari R,Capecchi PL,Picano E

    更新日期：2003-12-01 00:00:00

  • The dysmetabolic syndrome.

    abstract：:The first unifying definition for the metabolic syndrome was proposed by WHO in 1998. In accordance to this, patients with type 2 diabetes mellitus or impaired glucose tolerance have the syndrome if they fulfil two of the criteria: hypertension, dyslipidaemia, obesity/abdominal obesity and microalbuminuria. Persons wi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.2001.00864.x

    authors： Groop L,Orho-Melander M

    更新日期：2001-08-01 00:00:00

  • The epidemiology of hepatocellular carcinoma in patients with acute intermittent porphyria.

    abstract：OBJECTIVE:To describe the epidemiology, pathogenesis and clinical features of hepatocellular carcinoma (HCC) in patients with acute intermittent porphyria (AIP). DESIGN:A retrospective population-based mortality study. SUBJECTS:All inhabitants who died between 1978-1990 (2122) including 33 with AIP, in two municipali...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1996.21847000.x

    authors： Andersson C,Bjersing L,Lithner F

    更新日期：1996-10-01 00:00:00

  • Rapid Emergency Medicine score: a new prognostic tool for in-hospital mortality in nonsurgical emergency department patients.

    abstract：OBJECTIVES:To evaluate the predictive accuracy of the scoring system Rapid Acute Physiology score (RAPS) in nonsurgical patients attending the emergency department (ED) regarding in-hospital mortality and length of stay in hospital (LOS), and to investigate whether the predictive ability of RAPS could be improved by ex...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2004.01321.x

    authors： Olsson T,Terent A,Lind L

    更新日期：2004-05-01 00:00:00

  • Drugs and femoral neck fracture: a case-control study.

    abstract：:Two hundred consecutive patients with femoral neck fractures (FNF) and 200 controls matched by age, sex, nursing home residency and number of admissions within the last 2 years, were interviewed about recent drug use. The matching criteria were chosen to achieve case and control groups that were comparable with regard...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1991.tb00302.x

    authors： Jensen J,Nielsen LH,Lyhne N,Hallas J,Brøsen K,Gram LF

    更新日期：1991-01-01 00:00:00

  • Determinants of longevity: genetic, environmental and medical factors.

    abstract：:This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past ce...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2796.1996.d01-2853.x

    authors： Christensen K,Vaupel JW

    更新日期：1996-12-01 00:00:00

  • Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis.

    abstract：:We report on a 43-year-old male patient with Ehlers-Danlos syndrome (EDS) type IV with acute myocardial infarction (MI) without organic coronary stenosis. The disease was complicated with pneumothorax, subcutaneous and mediastinal emphysema, and splenic artery rupture. Three of the patient's family members suffered su...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.2001.00761.x

    authors： Nishiyama Y,Nejima J,Watanabe A,Kotani E,Sakai N,Hatamochi A,Shinkai H,Kiuchi K,Tamura K,Shimada T,Takano T,Katayama Y

    更新日期：2001-01-01 00:00:00

  • Acute papillary muscle rupture in a patient with clostridial sepsis.

    abstract：:We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1046/j.1365-2796.1997.100115000.x

    authors： Schulz R,Andreas S,Weise B,Werner GS

    更新日期：1997-03-01 00:00:00

  • Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score.

    abstract：OBJECTIVE:Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk predi...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/joim.12189

    authors： Kleber ME,Goliasch G,Grammer TB,Pilz S,Tomaschitz A,Silbernagel G,Maurer G,März W,Niessner A

    更新日期：2014-08-01 00:00:00

  • Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up.

    abstract：OBJECTIVES:The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-...

    journal_title：Journal of internal medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2796.2001.00818.x

    authors： Agewall S,Fagerberg B,Berglund G,Schmidt C,Wendelhag I,Wikstrand J,Risk Factor Intervention Study Group, Sweden.

    更新日期：2001-04-01 00:00:00

  • Personalized medicine approaches in epilepsy.

    abstract：:Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time betw...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1111/joim.12322

    authors： Walker LE,Mirza N,Yip VLM,Marson AG,Pirmohamed M

    更新日期：2015-02-01 00:00:00

  • The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review.

    abstract：BACKGROUND:The UKPDS 34 showed that intensive treatment with metformin significantly reduces macrovascular end-points and mortality in individuals with newly diagnosed type 2 diabetes compared with intensive treatment with insulin or sulphonylurea derivatives, despite similar glycaemic control. How this should be expla...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/j.1365-2796.2004.01328.x

    authors： Wulffelé MG,Kooy A,de Zeeuw D,Stehouwer CD,Gansevoort RT

    更新日期：2004-07-01 00:00:00

  • Diagnosing isolated cardiac sarcoidosis.

    abstract：OBJECTIVES:Cardiac sarcoidosis (CS) without clinically apparent extracardiac disease may escape detection because of the poor sensitivity of endomyocardial biopsy (EMB). We set out to analyse our experience of repeated and imaging-guided biopsies in clinically isolated CS. METHODS:We retrospectively reviewed the medic...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2011.02396.x

    authors： Kandolin R,Lehtonen J,Graner M,Schildt J,Salmenkivi K,Kivistö SM,Kupari M

    更新日期：2011-11-01 00:00:00

  • Acetazolamide-associated aplastic anaemia.

    abstract：:Eleven cases of acetazolamide-associated aplastic anaemia were reported in Sweden during a 17-year period. There were six women and five men with a median age of 71 years (range 63-85 years). The median dose of acetazolamide was 500 mg, and the median duration of treatment was 3 months (range 2-71 months). Ten of the ...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1990.tb00290.x

    authors： Keisu M,Wiholm BE,Ost A,Mortimer O

    更新日期：1990-12-01 00:00:00

  • Prevalence of hyperinsulinaemia in patients with high blood pressure.

    abstract：:A total of 41 patients with hypertension were identified in a survey of 732 healthy factory workers. Twenty-three of these individuals were receiving antihypertensive medication, whereas 18 cases were newly discovered. Plasma glucose and insulin responses to oral glucose and fasting plasma triglyceride (TG), cholester...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.1992.tb00529.x

    authors： Zavaroni I,Mazza S,Dall'Aglio E,Gasparini P,Passeri M,Reaven GM

    更新日期：1992-03-01 00:00:00

  • Relationship of QT interval duration with carotid intima media thickness in a clinically healthy population undergoing cardiovascular risk screening.

    abstract：OBJECTIVES:To investigate the relationship between cardiac repolarization (QT interval duration) and intima media thickness (IMT) of the carotid arteries as surrogate measures of subclinical atherosclerosis. DESIGN:Prospective study with consecutive subjects enrolled in the SAPHIR program (Salzburg Atherosclerosis Pre...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2004.01436.x

    authors： Strohmer B,Pichler M,Iglseder B,Paulweber B

    更新日期：2005-03-01 00:00:00

  • Prospective study of body size and risk for stroke amongst women below age 60.

    abstract：:The relation between obesity, particularly abdominal obesity, and risk of stroke amongst women remains unclear. In 1991-1992, a prospective study was initiated in Sweden amongst women who returned a self-administered questionnaire. Through linkage with nation-wide registries, 45,449 women, free of stroke at entry, wer...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：10.1111/j.1365-2796.2006.01706.x

    authors： Lu M,Ye W,Adami HO,Weiderpass E

    更新日期：2006-11-01 00:00:00

  • Old patients with hypertension. A 25-year observational study of a geographically defined population (Dalby), aged 67 years at entry.

    abstract：OBJECTIVES:To evaluate the impact of hypertension and other risk factors on mortality, in particular cardiovascular mortality, in a geographically defined population of elderly subjects. DESIGN:An observational 25-year study of a total population. SETTING:The local health centre in the village of Dalby in southern Sw...

    journal_title：Journal of internal medicine

    pub_type： 杂志文章

    doi：

    authors： Lidfeldt J,Lanke J,Sundquist J,Lindholm LH

    更新日期：1998-12-01 00:00:00