Abstract:
OBJECTIVE:Therapeutic paracentesis in patients with cirrhosis is associated with a circulatory dysfunction. Intravenous albumin has been used to prevent the circulatory dysfunction; however, the use of albumin is controversial and costly. Splanchnic vasodilation is mainly responsible for circulatory dysfunction in these patients. There are no reports of use of noradrenaline, a vasoconstrictor, on the prevention of paracentesis-induced circulatory dysfunction in patients with cirrhosis. Therefore, we studied the preventive effect of noradrenaline on paracentesis-induced circulatory dysfunction in patients with cirrhosis after therapeutic paracentesis and compared it with that of intravenous albumin in a randomized pilot study. METHODS:Forty patients with cirrhosis and tense ascites underwent therapeutic paracentesis with albumin or noradrenaline in a randomized controlled trial at a tertiary centre. Effective arterial blood volume was assessed by measuring plasma renin activity at baseline and at 6 days after treatment. RESULTS:Effective arterial blood volume as indicated by plasma renin activity before and 6 days after paracentesis did not differ in the two groups (20.62 +/- 10.27-22.02 +/- 10.15 ng mL(-1) h(-1); P = 0.11 in the albumin group and 19.66 +/- 8.91-20.78 +/- 9.41 ng mL(-1) h(-1); P = 0.37 in the noradrenaline group). Plasma aldosterone concentration before and 6 days after paracentesis were also similar in both groups (1196.5 +/- 434.2-1217.0 +/- 405.7 pg mL(-1); P = 0.7 in the albumin group and 1206.0 +/- 522.5-1273.5 +/- 444.8 pg mL(-1); P = 0.22 in the noradrenaline group). The cost of noradrenaline treatment was significantly lower when compared with that of albumin (P < 0.001). CONCLUSIONS:Noradrenaline is as effective as albumin in preventing paracentesis-induced circulatory dysfunction in patients with cirrhosis after therapeutic paracentesis, but at a fraction of the cost.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Singh V,Kumar B,Nain CK,Singh B,Sharma N,Bhalla A,Sharma AKdoi
10.1111/j.1365-2796.2006.01654.xsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
62-8issue
1eissn
0954-6820issn
1365-2796pii
JIM1654journal_volume
260pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:The aim of the present study was to ascertain the degree of occurrence of tuberculous infection in patients presenting with low back pain (LBP). METHODS:Forty consecutive patients seeking primary medical attention for the main symptom of LBP and presenting to the Rheumatology Outpatient Clinic of our institu...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.2006.01675.x
更新日期:2006-08-01 00:00:00
abstract::Cytokine production is necessary to protect against pathogens and promote tissue repair, but excessive cytokine release can lead to systemic inflammation, organ failure and death. Inflammatory responses are finely regulated to effectively guard from noxious stimuli. The central nervous system interacts dynamically wit...
journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2796.2009.02098.x
更新日期:2009-06-01 00:00:00
abstract::The relation between obesity, particularly abdominal obesity, and risk of stroke amongst women remains unclear. In 1991-1992, a prospective study was initiated in Sweden amongst women who returned a self-administered questionnaire. Through linkage with nation-wide registries, 45,449 women, free of stroke at entry, wer...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.2006.01706.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:The efficacy of octreotide was studied in a group of patients with biochemical evidence of insulinoma. DESIGN:A phase-II study. SETTING:A university department of internal medicine. SUBJECTS:Seven patients with biochemical evidence of insulinoma and without metastatic lesions. INTERVENTION:Daily treatmen...
journal_title:Journal of internal medicine
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2796.1994.tb01067.x
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Apolipoprotein A-V (apoAV) contributes to the regulation of triglyceride metabolism, which plays a role in the pathogenesis of atherosclerotic diseases. We therefore ascertained determinants of hepatic APOA5 transcript and apoAV plasma levels in humans. DESIGN:We determined influences of anthropometric varia...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.2008.01987.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:The Cardiovascular Risk in Young Finns Study is an on-going multicentre study of atherosclerosis precursors in Finnish children and young adults. We have collected risk factor data in the 21-year follow-up performed in 2001. The aims of this analysis were to examine the levels, secular trends and east-west d...
journal_title:Journal of internal medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2796.2004.01308.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN:A cross-sectional study. SETTING AND SUBJECTS:The prevalence and extent of coronary and car...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/joim.12002
更新日期:2013-03-01 00:00:00
abstract::Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic var...
journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2796.2012.02587.x
更新日期:2012-11-01 00:00:00
abstract::A patient with undiagnosed, long-standing coeliac disease had multiple hot spots on skeletal scintigraphy, similar to those observed in malignant disease metastatic to the skeleton. A gluten-free diet corrected the pathological laboratory values, and a repeat skeletal scintigram 15 months after the first one was norma...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1990.tb00252.x
更新日期:1990-10-01 00:00:00
abstract::Two hundred consecutive patients with femoral neck fractures (FNF) and 200 controls matched by age, sex, nursing home residency and number of admissions within the last 2 years, were interviewed about recent drug use. The matching criteria were chosen to achieve case and control groups that were comparable with regard...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1991.tb00302.x
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the concentrations of magnesium (Mg), potassium (K) and sodium,potassium pumps (Na,K pumps) in skeletal muscle in patients with chronic obstructive lung disease (COLD) treated with or without diuretics. DESIGN:An open cross-sectional study. SETTING:COLD patients admitted to the Medical Departme...
journal_title:Journal of internal medicine
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更新日期:1997-01-01 00:00:00
abstract::Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system, is today a leading cause of unpredictable lifelong disability in young adults. The treatment of patients in progressive stages remains highly challenging, alluding to our limited understanding of ...
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pub_type: 杂志文章,评审
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journal_title:Journal of internal medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2008-07-01 00:00:00
abstract::Studies of zinc status in insulin-dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B-cell. We therefore prospectively followed 26 patients (14 males and 12 femal...
journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1989.tb01353.x
更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2013-11-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1995.tb00925.x
更新日期:1995-09-01 00:00:00
abstract::During the course of an inflammatory process in the thoracic part of the spinal cord, a previously healthy male suffered two myocardial infarctions in separate coronary territories. A coronary angiogram revealed only minor wall changes in one coronary artery. We hypothesize that the myocardial infarctions may have bee...
journal_title:Journal of internal medicine
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
doi:10.1111/j.1365-2796.1990.tb00185.x
更新日期:1990-07-01 00:00:00
abstract::This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases b...
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2020-12-30 00:00:00
abstract::Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, inc...
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pub_type: 杂志文章
doi:10.1111/j.1365-2796.1993.tb00765.x
更新日期:1993-10-01 00:00:00
abstract::We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use...
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pub_type: 杂志文章
doi:10.1046/j.1365-2796.2001.00848.x
更新日期:2001-09-01 00:00:00
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journal_title:Journal of internal medicine
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更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Evidence of an association between job strain and obesity is inconsistent, mostly limited to small-scale studies, and does not distinguish between categories of underweight or obesity subclasses. OBJECTIVES:To examine the association between job strain and body mass index (BMI) in a large adult population. ...
journal_title:Journal of internal medicine
pub_type: 杂志文章,meta分析
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更新日期:2012-07-01 00:00:00
abstract::The first unifying definition for the metabolic syndrome was proposed by WHO in 1998. In accordance to this, patients with type 2 diabetes mellitus or impaired glucose tolerance have the syndrome if they fulfil two of the criteria: hypertension, dyslipidaemia, obesity/abdominal obesity and microalbuminuria. Persons wi...
journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1111/joim.12279
更新日期:2015-01-01 00:00:00