Job strain in relation to body mass index: pooled analysis of 160 000 adults from 13 cohort studies.

Abstract:

BACKGROUND:Evidence of an association between job strain and obesity is inconsistent, mostly limited to small-scale studies, and does not distinguish between categories of underweight or obesity subclasses. OBJECTIVES:To examine the association between job strain and body mass index (BMI) in a large adult population. METHODS:We performed a pooled cross-sectional analysis based on individual-level data from 13 European studies resulting in a total of 161 746 participants (49% men, mean age, 43.7 years). Longitudinal analysis with a median follow-up of 4 years was possible for four cohort studies (n = 42 222). RESULTS:A total of 86 429 participants were of normal weight (BMI 18.5-24.9 kg m(-2) ), 2149 were underweight (BMI < 18.5 kg m(-2) ), 56 572 overweight (BMI 25.0-29.9 kg m(-2) ) and 13 523 class I (BMI 30-34.9 kg m(-2) ) and 3073 classes II/III (BMI ≥ 35 kg m(-2) ) obese. In addition, 27 010 (17%) participants reported job strain. In cross-sectional analyses, we found increased odds of job strain amongst underweight [odds ratio 1.12, 95% confidence interval (CI) 1.00-1.25], obese class I (odds ratio 1.07, 95% CI 1.02-1.12) and obese classes II/III participants (odds ratio 1.14, 95% CI 1.01-1.28) as compared with participants of normal weight. In longitudinal analysis, both weight gain and weight loss were related to the onset of job strain during follow-up. CONCLUSIONS:In an analysis of European data, we found both weight gain and weight loss to be associated with the onset of job strain, consistent with a 'U'-shaped cross-sectional association between job strain and BMI. These associations were relatively modest; therefore, it is unlikely that intervention to reduce job strain would be effective in combating obesity at a population level.

journal_name

J Intern Med

authors

Nyberg ST,Heikkilä K,Fransson EI,Alfredsson L,De Bacquer D,Bjorner JB,Bonenfant S,Borritz M,Burr H,Casini A,Clays E,Dragano N,Erbel R,Geuskens GA,Goldberg M,Hooftman WE,Houtman IL,Jöckel KH,Kittel F,Knutsson A,Kos

doi

10.1111/j.1365-2796.2011.02482.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

65-73

issue

1

eissn

0954-6820

issn

1365-2796

journal_volume

272

pub_type

杂志文章,meta分析
  • A patient with osteomalacia as single presenting symptom of gluten-sensitive enteropathy.

    abstract::A 59-year-old male patient presented with invalidating osteomalacia of 2.5 years' duration. The osteomalacia was caused by severe malabsorption due to gluten-sensitive enteropathy (GSE). There were no other signs or symptoms of GSE in this patient. Clinical presentation with monosymptomatic osteomalacia is very unusua...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1992.tb00554.x

    authors: De Boer WA,Tytgat GN

    更新日期:1992-07-01 00:00:00

  • Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study.

    abstract:BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/joim.12052

    authors: Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

    更新日期:2013-07-01 00:00:00

  • Poikilothermia syndrome.

    abstract::Poikilothermia syndrome is a rare cause of intrinsic thermoregulatory failure. Patients with this syndrome regulate body temperature poorly, if at all. Recently, a patient was referred to us who had clinical evidence of poikilothermia syndrome, as well as long-standing multiple sclerosis. Computerized tomography and m...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2796.1998.00384.x

    authors: Kurz A,Sessler DI,Tayefeh F,Goldberger R

    更新日期:1998-11-01 00:00:00

  • Tobacco use, cancer causation and public health impact.

    abstract::This review describes global patterns of tobacco use and the mechanisms by which tobacco use is involved in carcinogenesis. A second part will discuss the association between tobacco use and risk of specific cancer types. Tobacco use has traditionally been a practice of high-income countries, but it has recently been ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2796.2002.00993.x

    authors: Kuper H,Adami HO,Boffetta P

    更新日期:2002-06-01 00:00:00

  • Clinical presentation and treatment of orthopaedic implant-associated infection.

    abstract::Orthopaedic implants are highly susceptible to infection. The aims of treatment of infection associated with internal fixation devices are fracture consolidation and prevention of chronic osteomyelitis. Complete biofilm eradication is not the primary goal, as remaining adherent microorganisms can be removed with the d...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/joim.12233

    authors: Zimmerli W

    更新日期:2014-08-01 00:00:00

  • Hypoglycaemia caused by atypical insulin antibodies in a patient with benign monoclonal gammopathy.

    abstract::We describe a 48-year-old woman with recurrent severe hypoglycaemia apparently caused by a paraprotein with insulin-binding capacity. Very high fasting values were found for serum insulin (170 and > 250 mU l-1) as well as for proinsulin 125 pmol l-1 and an insulinoma was suspected. Hypoglycaemia developed after an ora...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1993.tb00766.x

    authors: Arnqvist HJ,Halban PA,Mathiesen UL,Zahnd G,von Schenck H

    更新日期:1993-10-01 00:00:00

  • Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene.

    abstract::APOA5 encodes a novel apolipoprotein (apo A-V) which appears to be a modulator of plasma triglyceride (TG). In apoA5 knock out mice plasma TG level increases almost fourfold, whereas in human APOA5 transgenic mice it decreases by 70%. Some SNPs in the APOA5 gene have been associated with variations in plasma TG in hum...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2007.01912.x

    authors: Priore Oliva C,Carubbi F,Schaap FG,Bertolini S,Calandra S

    更新日期:2008-04-01 00:00:00

  • Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors.

    abstract::Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well-documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase-derived prostaglandins which act to modulate pathologic processes that would normally imp...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2796.2003.01146.x

    authors: Gambaro G,Perazella MA

    更新日期:2003-06-01 00:00:00

  • Prevalence and extent of subclinical atherosclerosis in patients with psoriasis.

    abstract:OBJECTIVE:Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN:A cross-sectional study. SETTING AND SUBJECTS:The prevalence and extent of coronary and car...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/joim.12002

    authors: Yiu KH,Yeung CK,Zhao CT,Chan JC,Siu CW,Tam S,Wong CS,Yan GH,Yue WS,Khong PL,Chan HH,Tse HF

    更新日期:2013-03-01 00:00:00

  • Thrombosis formation on atherosclerotic lesions and plaque rupture.

    abstract::Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of cardiovascular ischaemic events. The evolution of vascular disease involves a combination of endothelial dysfunction, extensive lipid deposition in the intima, exacerbated innate and adaptive immune responses, proliferation of ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.12296

    authors: Badimon L,Vilahur G

    更新日期:2014-12-01 00:00:00

  • The origins of the developmental origins theory.

    abstract::Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-u...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2007.01809.x

    authors: Barker DJ

    更新日期:2007-05-01 00:00:00

  • Epigenetic insights into multiple sclerosis disease progression.

    abstract::Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system, is today a leading cause of unpredictable lifelong disability in young adults. The treatment of patients in progressive stages remains highly challenging, alluding to our limited understanding of ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.13045

    authors: Kular L,Jagodic M

    更新日期:2020-07-01 00:00:00

  • Gamma-glutamyl transpeptidase and the metabolic syndrome.

    abstract:OBJECTIVE:To analyse the associations between serum gamma-glutamyl transpeptidase activity (GTP) and the components of the metabolic syndrome. DESIGN:Cross-sectional, observational study of hypertensive patients and controls. SETTING:The participating subjects visited the research laboratory of the Department of Inte...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1046/j.1365-2796.2000.00723.x

    authors: Rantala AO,Lilja M,Kauma H,Savolainen MJ,Reunanen A,Kesäniemi YA

    更新日期:2000-09-01 00:00:00

  • Reflexogenic neuronal and humoral responses to selective stimulation of low-pressure cardiopulmonary receptors in man.

    abstract::This study was conducted to determine the relative importance of efferent muscle sympathetic nerve activity (MSA), vasopressin (ADH) and atrial natriuretic peptide (ANP) in the short-term neurohumoral response to moderate changes in low-pressure cardiopulmonary receptor activity. The low-pressure receptors were stimul...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1991.tb00323.x

    authors: Agewall S,Rhea B,Persson B,Karlberg B,Wallin G,Andersson OK

    更新日期:1991-02-01 00:00:00

  • The role of microRNA in nutritional control.

    abstract::MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar a...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/joim.12372

    authors: Nolte-'t Hoen EN,Van Rooij E,Bushell M,Zhang CY,Dashwood RH,James WP,Harris C,Baltimore D

    更新日期:2015-08-01 00:00:00

  • Two IgM paraproteins bearing cryoglobulin and anti-smooth muscle activities in a patient with Waldenström's macroglobulinaemia.

    abstract::A 52-year-old white male subject with typical clinical and laboratory findings of Waldenström's macroglobulinaemia is described. Two paraprotein peaks of IgM lambda class, with different physical and chemical properties and different amino acid compositions, in both heavy and light chains, were found in the patient's ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1991.tb00312.x

    authors: Ruiz-Palomo F,Revilla Y,Gonzales Porque P,Serrano Rios M

    更新日期:1991-01-01 00:00:00

  • Dental infections in association with cerebral infarction in young and middle-aged men.

    abstract::The association between dental infections and cerebral infarction was investigated in a case-control study involving 40 patients with ischaemic cerebral infarction under the age of 50, and 40 randomly selected community controls matched for sex and age. Poor oral health, as assessed by two indices measuring the severi...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1989.tb00060.x

    authors: Syrjänen J,Peltola J,Valtonen V,Iivanainen M,Kaste M,Huttunen JK

    更新日期:1989-03-01 00:00:00

  • Gastrointestinal inflammation: lessons from metabolic modulators.

    abstract::The link between inflammation and metabolism was apparent already early last century, but has recently been revitalized following molecular studies of atherosclerosis, obesity and insulin resistance. A growing list of nuclear receptors, pivotal players in lipid, xenobiotic and energy metabolism has been identified as ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2796.2008.01964.x

    authors: Arulampalam V

    更新日期:2008-06-01 00:00:00

  • High D-dimer levels increase the likelihood of pulmonary embolism.

    abstract::Objective. To determine the utility of high quantitative D-dimer levels in the diagnosis of pulmonary embolism. Methods. D-dimer testing was performed in consecutive patients with suspected pulmonary embolism. We included patients with suspected pulmonary embolism with a high risk for venous thromboembolism, i.e. hosp...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2796.2008.01972.x

    authors: Tick LW,Nijkeuter M,Kramer MH,Hovens MM,Büller HR,Leebeek FW,Huisman MV,Christopher Study Investigators.

    更新日期:2008-08-01 00:00:00

  • The required beta cell research for improving treatment of type 2 diabetes.

    abstract::In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hypergl...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.12096

    authors: Thorens B

    更新日期:2013-09-01 00:00:00

  • Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension.

    abstract:OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1995.tb01158.x

    authors: Morise T,Takeuchi Y,Takeda R

    更新日期:1995-02-01 00:00:00

  • Age-related increase of pulse pressure and plasminogen activator inhibitor-1 I/D gene polymorphism in essential hypertension.

    abstract:BACKGROUND:Pulse pressure (PP), a marker of cyclic strain on the arterial wall, is a significant predictor of cardiovascular (CV) risk, particularly regarding the incidence of coronary arterial stenosis. Genes related to haemostatic and/or fibrinolytic factors are consistently influenced in vitro by mechanical strain. ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2004.01427.x

    authors: Mourad JJ,du Cailar G,Nazal EM,Safar ME,Mimran A

    更新日期:2005-01-01 00:00:00

  • The hospital: battleground or meeting place? Ethical considerations regarding a fair distribution of new medical technologies.

    abstract::Here, the notion of distributive justice is explored in relation to the introduction and the application of new medical technologies within the clinical setting. The point of departure is that, in the decision making process on what is necessary and fair in patient care, participants will mobilize different ethical mo...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.1995.tb01237.x

    authors: van der Kloot Meijburg HH

    更新日期:1995-12-01 00:00:00

  • The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.

    abstract:OBJECTIVE:To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL) in chronic heart failure (HF) of ischaemic aetiology. BACKGROUND:Neutrophil gelatinase-associated lipocalin is a marker of kidney injury as well as matrix degradation and inflammation and has previously been shown to be increa...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2796.2011.02503.x

    authors: Nymo SH,Ueland T,Askevold ET,Flo TH,Kjekshus J,Hulthe J,Wikstrand J,McMurray J,Van Veldhuisen DJ,Gullestad L,Aukrust P,Yndestad A

    更新日期:2012-05-01 00:00:00

  • Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.

    abstract:OBJECTIVES:To study fasting and postmethionine-loading (increment and decrement) plasma homocysteine levels in end-stage renal disease (ESRD) patients in relation to B-vitamin status and after folic acid treatment without or with betaine. DESIGN:Plasma total homocysteine (tHcy) and methionine levels were measured in c...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2796.1999.00430.x

    authors: van Guldener C,Janssen MJ,de Meer K,Donker AJ,Stehouwer CD

    更新日期:1999-02-01 00:00:00

  • Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis.

    abstract:BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-2796.2012.02576.x

    authors: Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

    更新日期:2013-01-01 00:00:00

  • Relationship of QT interval duration with carotid intima media thickness in a clinically healthy population undergoing cardiovascular risk screening.

    abstract:OBJECTIVES:To investigate the relationship between cardiac repolarization (QT interval duration) and intima media thickness (IMT) of the carotid arteries as surrogate measures of subclinical atherosclerosis. DESIGN:Prospective study with consecutive subjects enrolled in the SAPHIR program (Salzburg Atherosclerosis Pre...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1365-2796.2004.01436.x

    authors: Strohmer B,Pichler M,Iglseder B,Paulweber B

    更新日期:2005-03-01 00:00:00

  • Effects of long-term treatment with metoprolol and hydrochlorothiazide on plasma lipids and lipoproteins.

    abstract::In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood pressure was in the range 95-120 mmHg were randomly allocated to groups that received either hydrochlorothiazide or metoprolol, or both drugs when the response to one of them was...

    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2796.1990.tb00240.x

    authors: Monmany J,Domingo P,Gomez JA,Sanz F,Roca-Cusachs A,Nolla J,Jane F

    更新日期:1990-10-01 00:00:00

  • Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease.

    abstract::Cardiovascular disorders including hypertension and associated renal disease are major health problems affecting more than 1.5 billion people worldwide. Apart from nonmodifiable factors such as ageing, family history and gender, both sedentary lifestyle and unhealthy dietary habits are considered as major risk factors...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.12818

    authors: Carlstrom M,Montenegro MF

    更新日期:2019-01-01 00:00:00

  • Coeliac disease and noncoeliac wheat or gluten sensitivity.

    abstract::Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are requ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1111/joim.13120

    authors: Rej A,Aziz I,Sanders DS

    更新日期:2020-11-01 00:00:00