Strategies for the prevention of senile (type II) osteoporosis: an update.

abstract：:Somatostatin receptors are expressed on the majority of neuroendocrine tumours. The presence of these receptors is clinically useful. First, long-term treatment with somatostatin analogues controls hormonal hypersecretion, which controls flushing attacks, watery diarrhoea, hypoglycaemia and electrolyte disorders in pa...

journal_title：Journal of internal medicine

authors： Lamberts SW,Hofland LJ,Lely AJ,de Herder WW

更新日期：1998-06-01 00:00:00

abstract：:Hepatitis C virus infection is now one of the most important causes of chronic liver disease. Primary care physicians play an important role in the diagnosis and initial work-up of patients infected with this virus. Understanding which patients may be at risk is the first step. By understanding the correct use of hepa...

journal_title：Journal of internal medicine

authors： Larson AM,Carithers RL

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated t...

journal_title：Journal of internal medicine

authors： Abbenhardt C,McTiernan A,Alfano CM,Wener MH,Campbell KL,Duggan C,Foster-Schubert KE,Kong A,Toriola AT,Potter JD,Mason C,Xiao L,Blackburn GL,Bain C,Ulrich CM

更新日期：2013-08-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseas...

journal_title：Journal of internal medicine

authors： de Serres F,Blanco I

更新日期：2014-10-01 00:00:00

abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

journal_title：Journal of internal medicine

authors： Maegdefessel L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:A description of the clinical presentation, diagnostic procedure and mode of therapy in three patients suffering from chronic mesenteric ischaemia. DESIGN AND INTERVENTIONS:In all cases, the diagnosis was made on the basis of abdominal complaints in combination with angiographic findings. The primary treatm...

journal_title：Journal of internal medicine

authors： Hoogenberg K,Van Essen LH,Van den Dungen JJ,Limburg AJ,Boeve WJ,Kleibeuker JH

更新日期：1995-03-01 00:00:00

abstract：:The hypothesis that asymptomatic visual field defects can be found in patients with carotid transient ischaemic attacks (TIA) or minor strokes was tested. Twenty-two consecutive male patients with TIA and 18 patients with minor strokes from the carotid artery territory were examined by perimetry, cerebral computerised...

journal_title：Journal of internal medicine

authors： Falke P,Abela BM Jr,Krakau CE,Lilja B,Lindgärde F,Maly P,Stavenow L

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVES:The mortality from coronary heart disease (CHD) is exceptionally low in northernmost Finland, the Sámi (formerly known as Lapp) area. To clarify the reasons for this, the levels of serum cholesterol, other classic risk factors, and major antioxidants, alpha-tocopherol, retinol, albumin and selenium were dete...

journal_title：Journal of internal medicine

authors： Luoma PV,Näyhä S,Sikkilä K,Hassi J

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:To evaluate (i) the demineralizing effect of L-thyroxine (LT4) therapy at doses mildly inhibiting serum thyroid stimulating hormone (TSH) in patients with benign nodular goitre; (ii) the efficacy of treatment on nodule size. DESIGN:Cross-sectional study comparing euthyroid women with nodular goitre treated ...

journal_title：Journal of internal medicine

authors： Baldini M,Gallazzi M,Orsatti A,Fossati S,Leonardi P,Cantalamessa L

更新日期：2002-05-01 00:00:00

abstract：:Eleven cases of acetazolamide-associated aplastic anaemia were reported in Sweden during a 17-year period. There were six women and five men with a median age of 71 years (range 63-85 years). The median dose of acetazolamide was 500 mg, and the median duration of treatment was 3 months (range 2-71 months). Ten of the ...

journal_title：Journal of internal medicine

authors： Keisu M,Wiholm BE,Ost A,Mortimer O

更新日期：1990-12-01 00:00:00

abstract：:Neuroendocrine tumour of the small intestine (SI-NET), formerly known as midgut carcinoid tumour, is the most common small intestinal malignancy. The incidence is rising, with recent reports of 0.67 per 100 000 in the USA and 1.12 per 100 000 in Sweden. SI-NETs often present a challenge in terms of diagnosis and treat...

journal_title：Journal of internal medicine

authors： Stålberg P,Westin G,Thirlwell C

更新日期：2016-12-01 00:00:00

abstract：:Type 2 diabetes (T2DM) is a rapidly growing public health problem. It is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. The factors underlying incre...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:To examine the occurrence over time of the metabolic syndrome (MetS) according to different definitions and the relation to change during follow-up in carotid artery intima-media thickness (IMT), measured by ultrasound. DESIGN:A cohort of 316, originally 58-year-old men, initially free of diabetes and cardi...

journal_title：Journal of internal medicine

authors： Wallenfeldt K,Hulthe J,Fagerberg B

更新日期：2005-07-01 00:00:00

abstract：:Recent studies have demonstrated that replacement of C-peptide to normal physiological concentrations in insulin-dependent diabetic (IDDM) patients on a short-term basis (1-3 h) results in decreased glomerular hyperfiltration, augmented glucose utilization and improved autonomic nervous function. More prolonged admini...

journal_title：Journal of internal medicine

authors： Wahren J,Johansson BL,Wallberg-Henriksson H,Linde B,Fernqvist-Forbes E,Zierath JR

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to define the phenotype in three families with mild haemophilia A and to determine restriction fragment length polymorphisms (RFLP), which could support a hypothesis of a common progenitor of the families. DESIGN:Family survey. SETTING:Index cases were identified in and outside hos...

journal_title：Journal of internal medicine

authors： Jensson O,Stenbjerg Bernvil S,Jónsdóttir S,Ingerslev J

更新日期：1994-05-01 00:00:00

abstract：:A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for c...

journal_title：Journal of internal medicine

authors： Björkhem I

更新日期：2006-12-01 00:00:00

abstract：:As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer st...

journal_title：Journal of internal medicine

authors： Sutlu T,Alici E

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The contribution of plasma lipids to cardiovascular risk is usually evaluated by measuring plasma concentrations of total cholesterol, triglycerides and HDL cholesterol, and calculating LDL cholesterol concentration. We investigated plasma concentrations of apolipoproteins and lipoprotein particles in women ...

journal_title：Journal of internal medicine

authors： Nielsen NE,Olsson AG,Swahn E

更新日期：2000-01-01 00:00:00

abstract：:Dysbetalipoproteinaemia is a genetic disorder characterized by accumulation of lipoprotein remnant particles in the plasma, accelerated atherosclerosis, and the abnormal apoprotein E2. Uncontrolled diabetes mellitus can aggravate the hyperlipidaemia associated with this disorder, presumably by increasing triglyceride ...

journal_title：Journal of internal medicine

authors： Duell PB,Bierman EL

更新日期：1991-01-01 00:00:00

abstract：:We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use...

journal_title：Journal of internal medicine

authors： Punthakee Z,Scully LJ,Guindi MM,Ooi TC

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The relationship between physical activity and cognitive function is intriguing but controversial. We performed a systematic meta-analysis of all the available prospective studies that investigated the association between physical activity and risk of cognitive decline in nondemented subjects. METHODS:We con...

journal_title：Journal of internal medicine

authors： Sofi F,Valecchi D,Bacci D,Abbate R,Gensini GF,Casini A,Macchi C

更新日期：2011-01-01 00:00:00

abstract：:Clinical symptoms were studied in 69 consecutive patients below the age of 40 years who were attending the emergency unit because of unexplained chest pain. In a structured interview a few weeks after the emergency visit, only one-third of the patients reported that they believed in the doctor's diagnosis; they believ...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:To examine to what extent traditional biomedical risk factors and social factors can predict, separately or jointly, first-ever stroke event, and to explore to what extent other risk factors might add to hypertension/elevated blood pressure as a stroke risk factor. DESIGN:An incident case-referent study. S...

journal_title：Journal of internal medicine

authors： Ohgren B,Weinehall L,Stegmayr B,Boman K,Hallmans G,Wall S

更新日期：2000-12-01 00:00:00

abstract：:Forty-one patients with hyperprolactinaemia and suspected prolactinomas were studied. Growth hormone (GH) and thyrotropin (TSH) secretory patterns after thyrotropin releasing hormone (TRH) were affected in the majority of patients. The disturbances were observed regardless of tumour size as indicated by the radiologic...

journal_title：Journal of internal medicine

authors： Brismar K,Hulting AL,Werner S

更新日期：1990-11-01 00:00:00

abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

journal_title：Journal of internal medicine

authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

更新日期：2014-02-01 00:00:00

abstract：:Previous studies in patients with peripheral arterial disease (PAD) have shown that the prognosis is relatively good when the distal systolic ankle index (ankle systolic pressure/arm systolic pressure) is above 50% and the distal toe systolic pressure is above 40 mmHg. In 132 patients suspected of PAD in the legs we i...

journal_title：Journal of internal medicine

authors： Christensen JH,Freundlich M,Jacobsen BA,Falstie-Jensen N

更新日期：1989-08-01 00:00:00

abstract：:Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaph...

journal_title：Journal of internal medicine

authors： Serini G,Bussolino F,Maione F,Giraudo E

更新日期：2013-02-01 00:00:00

abstract：:The objective was to review the current status of meta-analysis, the process of combining the results of similar investigations, which was described in 1976. It has evolved rapidly, and thousands have already been published. Meta-analysis may be performed in a narrative form or in the preferred statistical format, whi...

journal_title：Journal of internal medicine

authors： Conn HO

更新日期：1997-03-01 00:00:00

abstract：:We investigated the determinants of maximal intima-media thickness of common carotid arteries in a population-based sample of 1224 Eastern Finnish men aged 42, 48, 54 or 60 years. A high-resolution B-mode ultrasonographic examination was performed as part of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD)....

journal_title：Journal of internal medicine

authors： Salonen R,Salonen JT

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:To study the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL) in chronic heart failure (HF) of ischaemic aetiology. BACKGROUND:Neutrophil gelatinase-associated lipocalin is a marker of kidney injury as well as matrix degradation and inflammation and has previously been shown to be increa...

journal_title：Journal of internal medicine

authors： Nymo SH,Ueland T,Askevold ET,Flo TH,Kjekshus J,Hulthe J,Wikstrand J,McMurray J,Van Veldhuisen DJ,Gullestad L,Aukrust P,Yndestad A

更新日期：2012-05-01 00:00:00