Abstract：
OBJECTIVE:The relationship between physical activity and cognitive function is intriguing but controversial. We performed a systematic meta-analysis of all the available prospective studies that investigated the association between physical activity and risk of cognitive decline in nondemented subjects. METHODS:We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library and bibliographies of retrieved articles up to January 2010. Studies were included if they analysed prospectively the association between physical activity and cognitive decline in nondemented subjects. RESULTS:After the review process, 15 prospective studies (12 cohorts) were included in the final analysis. These studies included 33,816 nondemented subjects followed for 1-12 years. A total of 3210 patients showed cognitive decline during the follow-up. The cumulative analysis for all the studies under a random-effects model showed that subjects who performed a high level of physical activity were significantly protected (-38%) against cognitive decline during the follow-up (hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.54-0.70; P < 0.00001). Furthermore, even analysis of low-to-moderate level exercise also showed a significant protection (-35%) against cognitive impairment (HR 0.65, 95% CI 0.57-0.75; P < 0.00001). CONCLUSION:This is the first meta-analysis to evaluate the role of physical activity on cognitive decline amongst nondemented subjects. The present results suggest a significant and consistent protection for all levels of physical activity against the occurrence of cognitive decline.
journal_name
J Intern Medjournal_title
Journal of internal medicineauthors
Sofi F,Valecchi D,Bacci D,Abbate R,Gensini GF,Casini A,Macchi Cdoi
10.1111/j.1365-2796.2010.02281.xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
107-17issue
1eissn
0954-6820issn
1365-2796journal_volume
269pub_type
杂志文章,meta分析,评审abstract：BACKGROUND:Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult. METHODS:Markers of cardiac stress (B-type natriuretic peptide, BNP) and inflammation (C-reactive protein, white blood cell count, procalcitonin) as well as t...
journal_title：Journal of internal medicine
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2796.2008.01934.x
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:A description of the clinical presentation, diagnostic procedure and mode of therapy in three patients suffering from chronic mesenteric ischaemia. DESIGN AND INTERVENTIONS:In all cases, the diagnosis was made on the basis of abdominal complaints in combination with angiographic findings. The primary treatm...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1995.tb01178.x
更新日期：1995-03-01 00:00:00
abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2796.1989.tb00089.x
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVES:It is well known that pulmonary function is associated with all-cause and cardiovascular (CV) death. Less is known about the association between respiratory symptoms and mortality and whether such an association is independent of physical fitness. In this study, we assessed the association of breathlessness ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2006.01693.x
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:The Cardiovascular Risk in Young Finns Study is an on-going multicentre study of atherosclerosis precursors in Finnish children and young adults. We have collected risk factor data in the 21-year follow-up performed in 2001. The aims of this analysis were to examine the levels, secular trends and east-west d...
journal_title：Journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2796.2004.01308.x
更新日期：2004-04-01 00:00:00
abstract：:The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12610
更新日期：2017-07-01 00:00:00
abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12298
更新日期：2014-12-01 00:00:00
abstract：:Studies of zinc status in insulin-dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B-cell. We therefore prospectively followed 26 patients (14 males and 12 femal...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb01353.x
更新日期：1989-07-01 00:00:00
abstract：OBJECTIVE:To study the impact of the cost of pharmaceuticals on physicians' decisions about drug prescription. DESIGN:A simulation protocol for the treatment of two patients, one with mild and the other with a severe form of urinary tract infection (UTI), was designed. Thirty family physicians in outpatient clinics an...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.137143000.x
更新日期：1997-05-01 00:00:00
abstract：:Ten adult patients with a severe nephrotic syndrome resistant to conventional immunosuppression were treated with cyclosporin A (CyA) for a mean period of 11 months. CyA was effective in all but two patients, as evaluated by 24-h urine protein excretion and clinical appearance. In general the best effect of CyA was se...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1990.tb00120.x
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:To evaluate beneficial effects of postmenopausal hormone replacement therapy (HRT) on endothelial function, measured as intraplatelet cyclic guanosine monophosphate (cGMP, mediator of nitric oxide), cyclic adenosine monophosphate (cAMP, mediator of prostacyclin) and plasma endothelin-1 (ET-1), and on monocyt...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2796.2000.00613.x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Lymphangioleiomyomatosis (LAM) can occur as in isolated form (sporadic LAM) or as a pulmonary manifestation of tuberous sclerosis complex (TSC) (TSC-associated LAM). Recent studies, however, revealed that both forms of LAM are genetically related but that sporadic LAM is a distinct clinical entity caused by ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2004.01356.x
更新日期：2004-08-01 00:00:00
abstract：:Transplantation of foetal dopamine neurons into the striatum of Parkinson's disease patients can provide restoration of the dopamine system and alleviate motor deficits. However, cellular replacement is associated with several problems. As with pharmacological treatments, cell therapy can lead to disabling abnormal in...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2009.02155.x
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To examine the feasibility and efficacy of a multifactorial intervention programme directed towards hypercholesterolaemia, smoking, and diabetes mellitus in treated hypertensive patients after more than 3 years' follow-up and to describe the incidence of cardiovascular complications. DESIGN:Open, randomized,...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2796.1994.tb00858.x
更新日期：1994-12-01 00:00:00
abstract：:We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.100115000.x
更新日期：1997-03-01 00:00:00
abstract：:A case of a 44-year-old patient with recurrent deep venous thrombosis (DVT) caused by congenital dysgenesis of the inferior vena cava (IVC) in coincidence with heterozygous factor V Leiden mutation is presented. The IVC malformation was a fortuitous finding because the vascular malformation of the collateral draining ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.2002.01034.x
更新日期：2002-09-01 00:00:00
abstract：:Genome-wide association studies have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.2012.02522.x
更新日期：2012-04-01 00:00:00
abstract：:Orthopaedic implants are highly susceptible to infection. The aims of treatment of infection associated with internal fixation devices are fracture consolidation and prevention of chronic osteomyelitis. Complete biofilm eradication is not the primary goal, as remaining adherent microorganisms can be removed with the d...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/joim.12233
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:To compare foreign- and Swedish-born diabetic subjects regarding health care utilization, complications, clinical and socio-economic characteristics. DESIGN:Cross-sectional study. SETTING:All known diabetic patients living in six defined primary health care districts. SUBJECTS:Of 1861 identified subjects ...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1997.00161.x
更新日期：1997-08-01 00:00:00
abstract：:Left ventricular filling pattern was assessed by pulsed Doppler echocardiography at rest and during handgrip exercise in 33 healthy middle-aged subjects. The peak mitral flow-velocities during the early rapid filling phase (E) and during late (atrial) filling (A) were measured and the ratio of these peak flow-velociti...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb01388.x
更新日期：1989-10-01 00:00:00
abstract：:Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system, is today a leading cause of unpredictable lifelong disability in young adults. The treatment of patients in progressive stages remains highly challenging, alluding to our limited understanding of ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.13045
更新日期：2020-07-01 00:00:00
abstract：:Neutrophil granules store proteins that are critically important for the neutrophil to move from the vascular bed to tissues and to kill microorganisms. This is illustrated in nature when individual proteins are deleted due to inherited mutations of their cognate genes, and such deficiencies result in the conditions l...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2010.02237.x
更新日期：2010-07-01 00:00:00
abstract：:To determine the effect of prednisolone on severe hypercalcaemia in women with metastatic breast cancer, 30 patients with serum ionized calcium above 1.60 mmol l-1 (reference range 1.15-1.35 mmol l-1) entered a randomized trial. Performance status before entry to the trial and survival time after hypercalcaemia were a...
journal_title：Journal of internal medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2796.1992.tb00578.x
更新日期：1992-09-01 00:00:00
abstract：:Pulsatile, intravenous insulin infusion designed to mimic the portal insulin concentrations that emerge physiologically after a meal, has been postulated to improve glucose tolerance in Type 1 (insulin-dependent) diabetic patients. We studied the effects of insulin pulsing (10 i.v. pulses of human insulin of 0.035 U k...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1111/j.1365-2796.1989.tb01403.x
更新日期：1989-11-01 00:00:00
abstract：:Monitoring survival of cancer patients using data collected by population-based cancer registries is an important component of cancer control. In this setting, patient survival is often summarized using net survival, that is survival from cancer if there were no other possible causes of death. Although net survival is...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.13139
更新日期：2021-01-01 00:00:00
abstract：:The systemic regulation of immune reactions by the nervous system is well studied and depends on the release of hormones. Some regional regulations of immune reactions, on the other hand, depend on specific neural pathways. Better understanding of these regulations will expand therapeutic applications for neuroimmune ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.12912
更新日期：2019-09-01 00:00:00
abstract：:Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are requ...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/joim.13120
更新日期：2020-11-01 00:00:00
abstract：AIM:To describe the mortality and mode of death over 5 years, and factors associated with death amongst patients with acute chest pain. PATIENTS:All patients who came to the emergency department at Sahlgrenska Hospital in Göteborg with acute chest pain or other symptoms raising suspicion of acute myocardial infarction...
journal_title：Journal of internal medicine
pub_type： 杂志文章
doi：10.1046/j.1365-2796.1998.00244.x
更新日期：1998-01-01 00:00:00
abstract：:A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for c...
journal_title：Journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2796.2006.01725.x
更新日期：2006-12-01 00:00:00
abstract：:Objective. To determine the utility of high quantitative D-dimer levels in the diagnosis of pulmonary embolism. Methods. D-dimer testing was performed in consecutive patients with suspected pulmonary embolism. We included patients with suspected pulmonary embolism with a high risk for venous thromboembolism, i.e. hosp...
journal_title：Journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2796.2008.01972.x
更新日期：2008-08-01 00:00:00
