Clinical symptoms in young adults with atypical chest pain attending the emergency department.


:Clinical symptoms were studied in 69 consecutive patients below the age of 40 years who were attending the emergency unit because of unexplained chest pain. In a structured interview a few weeks after the emergency visit, only one-third of the patients reported that they believed in the doctor's diagnosis; they believed in a psychological or cardiac origin of the pain more often than the doctors. The chest pain was most often described as oppressive and/or stabbing. In 95% of cases it was central or left-sided. Associated symptoms were commonly reported, breathlessness being most commonly reported by two-thirds of the patients, followed by dizziness, palpitation and numbness/tingling. Mental symptoms such as tiredness, anxiety and tension were frequently reported. On the basis of the background literature the aetiology is discussed. We conclude that immediate symptom analysis, including psychosomatic symptoms, particularly breathing problems, is of central importance.


J Intern Med


Roll M,Kollind M,Theorell T




Has Abstract


1991-09-01 00:00:00












  • Twenty-four hour ambulatory blood pressure in the population.

    abstract:OBJECTIVES:To establish a population-based 24-h ambulatory blood pressure (ABP) reference material with day/night mean BP calculated by standardized and true bedtimes. DESIGN:A cross-sectional study of 200 randomly selected subjects (20 men and 20 women in each 10-year age interval 20-70 years) in Linköping, Sweden. ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Nyström F,Malmström O,Karlberg BE,Ohman KP

    更新日期:1996-11-01 00:00:00

  • Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.

    abstract::We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI). Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases. Biological data mainly revealed hepatic failure and lactic acidosis. Histological examination of liver biopsies sho...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Bissuel F,Bruneel F,Habersetzer F,Chassard D,Cotte L,Chevallier M,Bernuau J,Lucet JC,Trepo C

    更新日期:1994-04-01 00:00:00

  • High serum alpha-tocopherol, albumin, selenium and cholesterol, and low mortality from coronary heart disease in northern Finland.

    abstract:OBJECTIVES:The mortality from coronary heart disease (CHD) is exceptionally low in northernmost Finland, the Sámi (formerly known as Lapp) area. To clarify the reasons for this, the levels of serum cholesterol, other classic risk factors, and major antioxidants, alpha-tocopherol, retinol, albumin and selenium were dete...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Luoma PV,Näyhä S,Sikkilä K,Hassi J

    更新日期:1995-01-01 00:00:00

  • The genetical history of humans and the great apes.

    abstract::When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Kaessmann H,Pääbo S

    更新日期:2002-01-01 00:00:00

  • Health economic evaluation of treatments for Alzheimer's disease: impact of new diagnostic criteria.

    abstract::The socio-economic impact of Alzheimer's disease (AD) and other dementias is enormous, and the potential economic challenges ahead are clear given the projected future numbers of individuals with these conditions. Because of the high prevalence and cost of dementia, it is very important to assess any intervention from...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Wimo A,Ballard C,Brayne C,Gauthier S,Handels R,Jones RW,Jonsson L,Khachaturian AS,Kramberger M

    更新日期:2014-03-01 00:00:00

  • Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels.

    abstract:OBJECTIVES:To determine whether mutations in APOA1 affect levels of high-density lipoprotein (HDL) cholesterol and to predict risk of ischaemic heart disease (IHD) and total mortality in the general population. BACKGROUND:Epidemiologically, risk of IHD is inversely related to HDL cholesterol levels. Mutations in apoli...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Haase CL,Frikke-Schmidt R,Nordestgaard BG,Kateifides AK,Kardassis D,Nielsen LB,Andersen CB,Køber L,Johnsen AH,Grande P,Zannis VI,Tybjaerg-Hansen A

    更新日期:2011-08-01 00:00:00

  • Frequency and effect of optimal anticoagulation before onset of ischaemic stroke in patients with known atrial fibrillation.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Indredavik B,Rohweder G,Lydersen S

    更新日期:2005-08-01 00:00:00

  • The prevalence of coronary heart disease in the multi-ethnic and high diabetes prevalence population of Mauritius.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Tuomilehto J,Li N,Dowse G,Gareeboo H,Chitson P,Fareed D,Min Z,Alberti KG,Zimmet P

    更新日期:1993-02-01 00:00:00

  • Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Kleber ME,Goliasch G,Grammer TB,Pilz S,Tomaschitz A,Silbernagel G,Maurer G,März W,Niessner A

    更新日期:2014-08-01 00:00:00

  • Prospective study of body size and risk for stroke amongst women below age 60.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Lu M,Ye W,Adami HO,Weiderpass E

    更新日期:2006-11-01 00:00:00

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    abstract::This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past ce...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Christensen K,Vaupel JW

    更新日期:1996-12-01 00:00:00

  • Predicting ischaemic stroke subtype from presenting systolic blood pressure: the BASIC Project.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,多中心研究


    authors: Meurer WJ,Sánchez BN,Smith MA,Lisabeth LD,Majersik JJ,Brown DL,Uchino K,Bonikowski FP,Mendizabal JE,Zahuranec DB,Morgenstern LB

    更新日期:2009-03-01 00:00:00

  • Quality of lipid-lowering therapy in patients with ischaemic heart disease: a register-based study in 3477 patients.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章,多中心研究


    authors: Kanstrup H,Lassen JF,Heickendorff L,Lauritzen T,Larsen ML

    更新日期:2004-03-01 00:00:00

  • Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension.

    abstract:OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Morise T,Takeuchi Y,Takeda R

    更新日期:1995-02-01 00:00:00

  • Angiotensin-converting enzyme gene polymorphism in relation to HLA-DR in sarcoidosis.

    abstract:OBJECTIVES:To investigate if an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene associates with HLA-DR alleles previously found to be of prognostic interest in Scandinavian sarcoidosis patients. This may contribute to characteristics associated with these HLA-DR alleles, such as a ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Planck A,Eklund A,Yamaguchi E,Grunewald J

    更新日期:2002-03-01 00:00:00

  • Hyaluronan turnover in relation to infection and sepsis.

    abstract::Sepsis is a major clinical problem in intensive care. The mortality in septic shock is high, and predominantly due to cardiovascular collapse and multiple organ dysfunction. In sepsis high levels of circulating hyaluronan have been found, correlating to disease severity and prognosis. The reason behind the increased l...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Berg S

    更新日期:1997-07-01 00:00:00

  • Neuronal cell replacement in Parkinson's disease.

    abstract::Transplantation of foetal dopamine neurons into the striatum of Parkinson's disease patients can provide restoration of the dopamine system and alleviate motor deficits. However, cellular replacement is associated with several problems. As with pharmacological treatments, cell therapy can lead to disabling abnormal in...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Hedlund E,Perlmann T

    更新日期:2009-10-01 00:00:00

  • Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma.

    abstract::There is good evidence that both inherited and environmental factors influence the risk of developing asthma. Only recently, large well-designed studies have been undertaken with the power to identify the genetic causes for asthma, and methods developed in parallel with the Human Genome Project, such as gene expressio...

    journal_title:Journal of internal medicine

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    authors: Melén E,Pershagen G

    更新日期:2012-08-01 00:00:00

  • Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways.

    abstract::This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases b...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Calderón-Larrañaga A,Vetrano DL,Ferrucci L,Mercer SW,Marengoni A,Onder G,Eriksdotter M,Fratiglioni L

    更新日期:2019-03-01 00:00:00

  • Climate change: present and future risks to health, and necessary responses.

    abstract::Recent observed changes in Earth's climate, to which humans have contributed substantially, are affecting various health outcomes. These include altered distributions of some infectious disease vectors (ticks at high latitudes, malaria mosquitoes at high altitudes), and an uptrend in extreme weather events and associa...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: McMichael AJ,Lindgren E

    更新日期:2011-11-01 00:00:00

  • Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study.

    abstract:OBJECTIVES:Obesity has generally been associated with higher bone density and lower fracture risk. However, weight-related indices of obesity may be related differently to health end-points, compared with fat-related indices (such as body fat distribution and fat mass), as they may capture different dimensions of obesi...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Moayyeri A,Luben RN,Wareham NJ,Khaw KT

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    abstract::Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of cardiovascular ischaemic events. The evolution of vascular disease involves a combination of endothelial dysfunction, extensive lipid deposition in the intima, exacerbated innate and adaptive immune responses, proliferation of ...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Badimon L,Vilahur G

    更新日期:2014-12-01 00:00:00

  • Brain regulation of food intake and appetite: molecules and networks.

    abstract::In the clinic, obesity and anorexia constitute prevalent problems whose manifestations are encountered in virtually every field of medicine. However, as the command centre for regulating food intake and energy metabolism is located in the brain, the basic neuroscientist sees in the same disorders malfunctions of a mod...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,评审


    authors: Broberger C

    更新日期:2005-10-01 00:00:00

  • A new model for classification of disease manifestations in primary Sjögren's syndrome: evaluation in a retrospective long-term study.

    abstract:OBJECTIVES:The clinical features of 80 patients with primary Sjögren's syndrome (PSS) were revised in order to evaluate the descriptive and analytical facilities of a newly proposed model for classification of the exocrine and nonexocrine disease manifestations in PSS. DESIGN:Retrospective, long-term (median 7.5 years...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Asmussen K,Andersen V,Bendixen G,Schiødt M,Oxholm P

    更新日期:1996-06-01 00:00:00

  • Low frequency of the common Norwegian and Finnish LDL-receptor mutations in Swedish patients with familial hypercholesterolaemia.

    abstract:OBJECTIVE:To evaluate the frequency of the common Finnish and Norwegian mutations in the low density lipoprotein (LDL) receptor gene in Swedish patients with familial hypercholesterolaemia (FH), and to start screening for other mutations in these patients. In contrast to the situation in Norway and Finland, where the f...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Lind S,Eriksson M,Rystedt E,Wiklund O,Angelin B,Eggertsen G

    更新日期:1998-07-01 00:00:00

  • No difference in blood thiamine diphosphate levels between Swedish Caucasian patients with congestive heart failure treated with furosemide and patients without heart failure.

    abstract:OBJECTIVES:To determine whether furosemide treatment in congestive heart failure (CHF) patients is associated with thiamine deficiency. DESIGN:Patients without heart failure and without diuretic treatment were included to compare with patients with CHF belonging to New York Heart Association (NYHA) functional class II...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Yue QY,Beermann B,Lindström B,Nyquist O

    更新日期:1997-12-01 00:00:00

  • Impact of a high-dose nitrate strategy on cardiac stress in acute heart failure: a pilot study.

    abstract:BACKGROUND:Intravenous nitrate therapy has been shown to improve short-term outcome of acute heart failure patients treated in the intensive care unit. The potential of a noninvasive high-dose nitrate strategy in the Emergency Department and the general ward remains unknown. METHODS:A total of 128 consecutive acute he...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Breidthardt T,Noveanu M,Potocki M,Reichlin T,Egli P,Hartwiger S,Socrates T,Gayat E,Christ M,Mebazaa A,Mueller C

    更新日期:2010-03-01 00:00:00

  • Metabolic remission with octreotide in patients with insulinoma.

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    journal_title:Journal of internal medicine

    pub_type: 临床试验,杂志文章


    authors: von Eyben FE,Grodum E,Gjessing HJ,Hagen C,Nielsen H

    更新日期:1994-03-01 00:00:00

  • Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis.

    abstract:BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

    journal_title:Journal of internal medicine

    pub_type: 杂志文章,meta分析


    authors: Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

    更新日期:2013-01-01 00:00:00

  • Assessment of thyroid and adrenal function in patients with familial amyloidotic polyneuropathy.

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    journal_title:Journal of internal medicine

    pub_type: 杂志文章


    authors: Olofsson BO,Grankvist K,Boman K,Forsberg K,Lafvas I,Lithner F

    更新日期:1989-05-01 00:00:00