The Swedish CArdioPulmonary BioImage Study: objectives and design.

abstract：:A young, apparently healthy, soldier developed acute muscle weakness and rhabdomyolysis following prolonged exercise. The resultant myoglobinuria caused severe acute renal failure. Further investigation revealed the presence of carnitine palmitoyltransferase deficiency as the cause of the rhabdomyolysis. Renal functio...

journal_title：Journal of internal medicine

authors： Berkman N,Meirow D,Katzir Z,Bar-On H

更新日期：1993-03-01 00:00:00

abstract：:Eleven cases of acetazolamide-associated aplastic anaemia were reported in Sweden during a 17-year period. There were six women and five men with a median age of 71 years (range 63-85 years). The median dose of acetazolamide was 500 mg, and the median duration of treatment was 3 months (range 2-71 months). Ten of the ...

journal_title：Journal of internal medicine

authors： Keisu M,Wiholm BE,Ost A,Mortimer O

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To develop a method to evaluate routine management practices concerning lipid-lowering treatment in patients with ischaemic heart disease (IHD) in a large geographic area. DESIGN:A register-based study linking information on IHD with cholesterol levels and prescriptions on lipid-lowering medications by perso...

journal_title：Journal of internal medicine

authors： Kanstrup H,Lassen JF,Heickendorff L,Lauritzen T,Larsen ML

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between the pituitary-adrenocortical function, abdominal obesity, and insulin resistance syndrome. DESIGN:A prospective study. SETTING:Helsinki University Hospital, Finland. SUBJECTS:Sixty-six healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin, C-peptide, cortis...

journal_title：Journal of internal medicine

authors： Hautanen A,Adlercreutz H

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:As reported by major clinical series in the literature, about 2% of patients receiving unfractionated heparin (UFH) develop immune-mediated (type II) heparin-induced thrombocytopenia (HIT) that may be complicated in 30-75% of cases by a paradoxical thrombotic syndrome (HITTS), either arterial or venous. HITT...

journal_title：Journal of internal medicine

authors： Fabris F,Luzzatto G,Soini B,Ramon R,Scandellari R,Randi ML,Girolami A

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Heart failure is characterized by chronically increased adenosine levels, which are thought to express a protective anti-heart failure activation of the adenosinergic system. The aim of the study was to assess whether the activation of adenosinergic system in idiopathic dilated cardiomyopathy (IDC) can be mi...

journal_title：Journal of internal medicine

authors： Laghi-Pasini F,Guideri F,Petersen C,Lazzerini PE,Sicari R,Capecchi PL,Picano E

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:The RET proto-oncogene is known to be the susceptibility gene for various disease phenotypes, including multiple endocrine neoplasia type 2 (MEN 2). Recent studies have also suggested an involvement of RET in the development of the mammalian kidney. Although kidney agenesis or dysgenesis has been observed in ...

journal_title：Journal of internal medicine

authors： Loré F,Talidis F,Di Cairano G,Renieri A

更新日期：2001-07-01 00:00:00

abstract：:Clonal haematopoiesis results from acquired mutations in haematopoietic stem and progenitor cells (HSPCs). These mutations can confer the HSPC with a competitive advantage, leading to their clonal expansion within the limiting bone marrow niche. This process is often insufficient to produce a haematologic malignancy; ...

journal_title：Journal of internal medicine

authors： Min KD,Kour A,Sano S,Walsh K

更新日期：2020-11-01 00:00:00

abstract：:We created the GIFTs, fusions of granulocyte-colony macrophage-stimulating-factor with IL-2, or IL-15 or IL-21, in order to stimulate distinct, but complimentary elements of the immune response. We found that the physical coupling of two functionally distinct cytokines as a bifunctional hybrid allowed for synergistic ...

journal_title：Journal of internal medicine

authors： Williams P,Galipeau J

更新日期：2011-01-01 00:00:00

abstract：:We studied the effect of sleeping in the head-up tilt (HUT) position, alone and in combination with fludrocortisone, on orthostatic tolerance and blood pressure (BP) in six patients with hypoadrenergic orthostatic hypotension. A high salt diet of 150-200 mmol Na+ d-1 was also administered. Combined treatment reduced o...

journal_title：Journal of internal medicine

authors： Ten Harkel AD,Van Lieshout JJ,Wieling W

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

journal_title：Journal of internal medicine

authors： Morise T,Takeuchi Y,Takeda R

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Elevated plasma levels of bilirubin, an endogenous antioxidant, have been associated with reduced risk of ischaemic heart disease (IHD) and myocardial infarction (MI). Whether this is a causal relationship remains unclear. OBJECTIVE:We tested the hypothesis that elevated plasma bilirubin is causally related...

journal_title：Journal of internal medicine

authors： Stender S,Frikke-Schmidt R,Nordestgaard BG,Grande P,Tybjaerg-Hansen A

更新日期：2013-01-01 00:00:00

abstract：:Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency, and by reducing surgical trauma, several observational studies suggest potentia...

journal_title：Journal of internal medicine

authors： Kastengren M,Svenarud P,Ahlsson A,Dalén M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:Few studies have simultaneously analysed the influence of elevated serum uric acid (UA) on acute myocardial infarction (AMI), ischaemic and haemorrhagic stroke (IS, HS) and congestive heart failure (CHF) in large healthy populations. We, here, examine UA as a risk factor for AMI, stroke and CHF by age and ge...

journal_title：Journal of internal medicine

authors： Holme I,Aastveit AH,Hammar N,Jungner I,Walldius G

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

journal_title：Journal of internal medicine

authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

更新日期：2011-03-01 00:00:00

abstract：:Pancreatic transplantation was performed in three patients with insulin-dependent diabetes mellitus in whom recurrent and severe episodes of hypoglycaemia had been found to be due to defective glucose counterregulation. Thus in these patients the spontaneous blood glucose recovery after insulin-induced hypoglycaemia (...

journal_title：Journal of internal medicine

authors： Bolinder J,Wahrenberg H,Persson A,Linde B,Tydén G,Groth CG,Ostman J

更新日期：1991-12-01 00:00:00

abstract：INTRODUCTION:Biomarkers have emerged as interesting predictors of risk in non-ST elevation acute coronary syndromes (non-ST ACS). The aim of this study was to define the utility of the combined measurement of troponin T (TnT), C-reactive protein (CRP), NT pro-brain natriuretic peptide (NT pro-BNP) and D-dimer as biomar...

journal_title：Journal of internal medicine

authors： Tello-Montoliu A,Marín F,Roldán V,Mainar L,López MT,Sogorb F,Vicente V,Lip GY

更新日期：2007-12-01 00:00:00

abstract：:In a 24-week randomized multicentre single-blind study, including mild to moderate hypertensives free from other diseases, the effect on blood lipids of captopril (n = 51) was studied and compared with that of metoprolol (n = 53). In order to keep the diastolic pressure less than 95 mm Hg, bendroflumethiazide was adde...

journal_title：Journal of internal medicine

authors： Foss OP,Jensen EK

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVES:To assess the long-term prognostic values of baseline demographic data, occurrence of vectorcardiographic signs of reperfusion, left ventricular function and coronary angiographic features. DESIGN:Longitudinal study of morbidity and mortality. SETTING:Coronary care unit at Danderyd Hospital, Stockholm, Swe...

journal_title：Journal of internal medicine

authors： Strandberg LE,Ericsson CG,O'Konor ML,Bergstrand L,Lundin P,Rehnqvist N,Tornvall P

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to define the phenotype in three families with mild haemophilia A and to determine restriction fragment length polymorphisms (RFLP), which could support a hypothesis of a common progenitor of the families. DESIGN:Family survey. SETTING:Index cases were identified in and outside hos...

journal_title：Journal of internal medicine

authors： Jensson O,Stenbjerg Bernvil S,Jónsdóttir S,Ingerslev J

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVES:The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-...

journal_title：Journal of internal medicine

authors： Agewall S,Fagerberg B,Berglund G,Schmidt C,Wendelhag I,Wikstrand J,Risk Factor Intervention Study Group, Sweden.

更新日期：2001-04-01 00:00:00

abstract：:Fifty consecutive patients with confirmed PCP received a high dose of cotrimoxazole for 14 d, or until development of intolerance, directly followed by reduced dose maintenance therapy. Seven individuals died during the high dose course. Twenty (47%) of the 43 survivors showed toxicity reactions that necessitated dose...

journal_title：Journal of internal medicine

authors： Eeftinck Schattenkerk JK,Lange JM,van Steenwijk RP,Danner SA

更新日期：1990-05-01 00:00:00

abstract：:Six patients with acute renal failure, in five cases due to acute crescentic glomerulonephritis and in one case due to total bilateral renal cortical necrosis, were studied. All had serum erythropoietin (EPO) concentrations in the normal range, despite a relatively severe anaemia. Half-life and plasma clearance of int...

journal_title：Journal of internal medicine

authors： Thaysen JH,Nielsen OJ,Brandi L,Szpirt W

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the association between the proximal level of the clot and the severity of pulmonary embolism (PE). METHODS:The cohort consisted of 99 consecutive patients with PE diagnosed by multi-detector computed tomography. A new score was constructed by calculating the mean val...

journal_title：Journal of internal medicine

authors： Ghanima W,Abdelnoor M,Holmen LO,Nielssen BE,Sandset PM

更新日期：2007-01-01 00:00:00

abstract：:To determine the effect of prednisolone on severe hypercalcaemia in women with metastatic breast cancer, 30 patients with serum ionized calcium above 1.60 mmol l-1 (reference range 1.15-1.35 mmol l-1) entered a randomized trial. Performance status before entry to the trial and survival time after hypercalcaemia were a...

journal_title：Journal of internal medicine

authors： Kristensen B,Ejlertsen B,Holmegaard SN,Krarup-Hansen A,Transbøl I,Mouridsen H

更新日期：1992-09-01 00:00:00

abstract：:Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, inc...

journal_title：Journal of internal medicine

authors： Wetzler M,Estrov Z,Talpaz M,Markowitz A,Gutterman JU,Kurzrock R

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women. DESIGN:The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February. SETTING:The municip...

journal_title：Journal of internal medicine

authors： Leppert J,Ringqvist A,Ahlner J,Myrdal U,Sørensen S,Ringqvist I

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:the aim of this study was to investigate the effects of a healthy Nordic diet (ND) on cardiovascular risk factors. DESIGN AND SUBJECTS:in a randomized controlled trial (NORDIET) conducted in Sweden, 88 mildly hypercholesterolaemic subjects were randomly assigned to an ad libitum ND or control diet (subjects'...

journal_title：Journal of internal medicine

authors： Adamsson V,Reumark A,Fredriksson IB,Hammarström E,Vessby B,Johansson G,Risérus U

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Phospholipid transfer protein (PLTP) is an emerging cardiometabolic risk marker that is important in high-density lipoprotein (HDL) and triglyceride metabolism. Plasma PLTP activity is elevated in type 2 diabetes mellitus, whereas glucose may regulate PLTP gene transcription in vitro. Of interest, common PLT...

journal_title：Journal of internal medicine

authors： Dullaart RP,Vergeer M,de Vries R,Kappelle PJ,Dallinga-Thie GM

更新日期：2012-05-01 00:00:00