Determinants of plasma apolipoprotein A-V and APOA5 gene transcripts in humans.

abstract：:Traumatic brain injury (TBI) is a major cause of acquired disability globally, and effective treatment methods are scarce. Lately, there has been increasing recognition of the devastating impact of TBI resulting from sports and other recreational activities, ranging from primarily sport-related concussions (SRC) but a...

journal_title：Journal of internal medicine

authors： Marklund N,Bellander BM,Godbolt AK,Levin H,McCrory P,Thelin EP

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Statins reduce low-density lipoprotein cholesterol (LDL-C) and can raise high-density lipoprotein cholesterol (HDL-C). HDL-bound paraoxonase-1 (PON1) is associated with variations in plasma HDL-C, and may, therefore, contribute to changes of HDL-C during statin therapy. DESIGN:The effects of baseline PON1 s...

journal_title：Journal of internal medicine

authors： Himbergen TM,van Tits LJ,Voorbij HA,de Graaf J,Stalenhoef AF,Roest M

更新日期：2005-11-01 00:00:00

abstract：:The past few years have witnessed a major breakthrough in the understanding of the molecular mechanisms and ultrastructural changes behind the development of proteinuria. The discovery of several proteins in the glomerular podocyte and slit diaphragm, where mutations lead to disease, has revealed the importance of thi...

journal_title：Journal of internal medicine

authors： Tryggvason K,Pettersson E

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：:In the developed world the majority of disease results from common, but complex disorders such as diabetes, obesity and cancer. Genetic variation explains a large proportion of an individual's risk of developing these diseases; however, success in identifying the particular gene variants involved has been limited. Rec...

journal_title：Journal of internal medicine

authors： Lango H,Weedon MN

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To compare family physicians' reported practice habits on hypertension in Sweden and Minnesota, and to assess to what extent different national guidelines account for differences. DESIGN:Random samples of family physicians were selected for telephone interviews on their practice of hypertension. SETTING:Pr...

journal_title：Journal of internal medicine

authors： Troein M,Arneson T,Råstam L,Pirie PL,Selander S,Luepker RV

更新日期：1995-09-01 00:00:00

abstract：:Primary hyperparathyroidism (HPT) has been associated with hypertension, hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. In the present study, plasma ionized calcium (Ca2+) was studied in relation to cardiovascular risk factors in 20 subjects with mild hypertension. Plasma Ca2+ was found to be negatively ...

journal_title：Journal of internal medicine

authors： Lind L,Wengle B,Lithell H,Ljunghall S

更新日期：1992-04-01 00:00:00

abstract：:In 76 consecutive patients who had received diuretics for 1-17 years for arterial hypertension or congestive heart failure, muscle concentrations of magnesium, potassium, and sodium-potassium pumps were significantly reduced compared to 31 age- and sex-matched controls. Thirty-six patients with muscle magnesium and/or...

journal_title：Journal of internal medicine

authors： Dørup I,Skajaa K,Thybo NK

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVES:To examine to what extent traditional biomedical risk factors and social factors can predict, separately or jointly, first-ever stroke event, and to explore to what extent other risk factors might add to hypertension/elevated blood pressure as a stroke risk factor. DESIGN:An incident case-referent study. S...

journal_title：Journal of internal medicine

authors： Ohgren B,Weinehall L,Stegmayr B,Boman K,Hallmans G,Wall S

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Atherosclerosis is a multifactorial disease, in part characterized by chronic inflammatory changes in the vessel wall and loss of normal physical and biochemical interactions between endothelial cells and smooth muscle cells. Previous studies [Hu J., Cotgreave IA. J Clin Invest; 99: 1-5] have ...

journal_title：Journal of internal medicine

authors： Boerma M,Forsberg L,Van Zeijl L,Morgenstern R,De Faire U,Lemne C,Erlinge D,Thulin T,Hong Y,Cotgreave IA

更新日期：1999-08-01 00:00:00

abstract：:The acquired immunodeficiency syndrome (AIDS) has been associated with abnormalities of adrenocortical function, and hypoaldosteronism due to hyporeninaemic hypoaldosteronism (HHA). We here report the case of a woman with AIDS associated with orthostatic hypotension, persistent hyponatraemia and hyperkalaemia, in whom...

journal_title：Journal of internal medicine

authors： Cobbs R,Pepper GM,Torres JG,Gruenspan HL

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Polymyalgia rheumatica (PMR) is a rheumatic disease that is characterized by intense activation of systemic inflammation. Systemic inflammation has been associated with an imbalance between endothelial injury and repair, defined by an increased number of circulating endothelial microparticles (EMPs) and a re...

journal_title：Journal of internal medicine

authors： Pirro M,Bocci EB,Di Filippo F,Schillaci G,Mannarino MR,Bagaglia F,Gerli R,Mannarino E

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The relationship between physical activity and cognitive function is intriguing but controversial. We performed a systematic meta-analysis of all the available prospective studies that investigated the association between physical activity and risk of cognitive decline in nondemented subjects. METHODS:We con...

journal_title：Journal of internal medicine

authors： Sofi F,Valecchi D,Bacci D,Abbate R,Gensini GF,Casini A,Macchi C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:It has been hypothesized that epicardial adipose tissue (EAT) exerts pathogenic effects on cardiac structures. We analysed the associations between EAT and both cardiovascular (CV) disease risk factors and CV events in patients with chronic kidney disease (CKD). PATIENTS AND METHODS:We included 277 nondialy...

journal_title：Journal of internal medicine

authors： Cordeiro AC,Amparo FC,Oliveira MA,Amodeo C,Smanio P,Pinto IM,Lindholm B,Stenvinkel P,Carrero JJ

更新日期：2015-07-01 00:00:00

abstract：:Cardiovascular disorders including hypertension and associated renal disease are major health problems affecting more than 1.5 billion people worldwide. Apart from nonmodifiable factors such as ageing, family history and gender, both sedentary lifestyle and unhealthy dietary habits are considered as major risk factors...

journal_title：Journal of internal medicine

authors： Carlstrom M,Montenegro MF

更新日期：2019-01-01 00:00:00

abstract：:We report on a 43-year-old male patient with Ehlers-Danlos syndrome (EDS) type IV with acute myocardial infarction (MI) without organic coronary stenosis. The disease was complicated with pneumothorax, subcutaneous and mediastinal emphysema, and splenic artery rupture. Three of the patient's family members suffered su...

journal_title：Journal of internal medicine

authors： Nishiyama Y,Nejima J,Watanabe A,Kotani E,Sakai N,Hatamochi A,Shinkai H,Kiuchi K,Tamura K,Shimada T,Takano T,Katayama Y

更新日期：2001-01-01 00:00:00

abstract：:A 40-year-old woman with previous parathyroidectomy for adenoma was found to have a serum calcium level of 5.35 mmol l-1 (21.4 mg dl-1). Inadvertent calcium overdose had occurred because of her mistaken belief that if some prescribed calcium was good, then more was better. Her misconception is in contrast with that of...

journal_title：Journal of internal medicine

authors： McAlister NH,Abrams HB,Schlosser R,Sturtridge W

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-med...

journal_title：Journal of internal medicine

authors： Holm Nielsen S,Tengryd C,Edsfeldt A,Brix S,Genovese F,Bengtsson E,Karsdal M,Leeming DJ,Nilsson J,Goncalves I

更新日期：2019-01-01 00:00:00

abstract：:Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time betw...

journal_title：Journal of internal medicine

authors： Walker LE,Mirza N,Yip VLM,Marson AG,Pirmohamed M

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Cardiac sarcoidosis (CS) without clinically apparent extracardiac disease may escape detection because of the poor sensitivity of endomyocardial biopsy (EMB). We set out to analyse our experience of repeated and imaging-guided biopsies in clinically isolated CS. METHODS:We retrospectively reviewed the medic...

journal_title：Journal of internal medicine

authors： Kandolin R,Lehtonen J,Graner M,Schildt J,Salmenkivi K,Kivistö SM,Kupari M

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between the pituitary-adrenocortical function, abdominal obesity, and insulin resistance syndrome. DESIGN:A prospective study. SETTING:Helsinki University Hospital, Finland. SUBJECTS:Sixty-six healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin, C-peptide, cortis...

journal_title：Journal of internal medicine

authors： Hautanen A,Adlercreutz H

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:To examine whether intermittent oral 1 alpha(OH)D3 treatment of patients on haemodialysis with secondary hyperparathyroidism (HPT) was able to maintain the marked suppression of PTH, which previously had been induced by an intermittent intravenous administration of 1 alpha(OH)D3. Simultaneously, the effect o...

journal_title：Journal of internal medicine

authors： Brandi L,Daugaard H,Egsmose C,Tvedegaard E,Kjaerulff Nielsen P,Olgaard K

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:The original definition of microalbuminuria (20-200 microg min-1 or 15-150 microg min-1 overnight) is based on studies of patients with diabetes, in whom microalbuminuria was associated with increased risk of chronic renal failure. In a recent report an overnight urinary albumin excretion (UAE) above only 5 ...

journal_title：Journal of internal medicine

authors： Klausen KP,Scharling H,Jensen JS

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:To clarify the mechanisms by which smoking is associated to toxic and nontoxic goitre and thyroid nodules. DESIGN:Cohort study. SETTING:Sweden. SUBJECTS:A cohort of 874,507 parous women identified through the Medical Birth Registry, with smoking behaviour assessed through self-reported information at the ...

journal_title：Journal of internal medicine

authors： Galanti MR,Granath F,Cnattingius S,Ekbom-Schnell A,Ekbom A

更新日期：2005-09-01 00:00:00

abstract：:Evaluation of pro-oxidant/antioxidant dietary factors in relation to individual susceptibility to cancer and cardiovascular disease is justified based on a review of the literature. This working hypothesis is amendable to further scientific validation from biomarkers with end-point sensitivity to oxygen radicals. So f...

journal_title：Journal of internal medicine

authors： Pero RW,Berglund G,Christie NT,Cosma GN,Frenkel K,Garte SJ,Janzon L,Olsson A,Seidegård J,Smulson ME

更新日期：1993-01-01 00:00:00

abstract：:Many people infected with the human immunodeficiency virus type-1 (HIV) exhibit mild or severe neurological problems, termed HIV-associated neurocognitive disorder (HAND), even when receiving antiretroviral therapy. Thus, novel adjunctive therapies must be developed to overcome the neurotoxic effect of HIV. New therap...

journal_title：Journal of internal medicine

authors： Avdoshina V,Bachis A,Mocchetti I

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed. OBJECTIVES:To clarify risk factors associated with bradykinin-mediated AE after thrombolysis for acute ischemic stroke. METHODS:In a case-contr...

journal_title：Journal of internal medicine

authors： Vigneron C,Lécluse A,Ronzière T,Bouillet L,Boccon-Gibod I,Gayet S,Doche E,Smadja D,Di Legge S,Dumont F,Gaudron M,Ion I,Marcel S,Sévin M,Vlaicu MB,Launay D,Arnaud I,Girard-Madoux P,Héroum C,Lefèvre S,Marc G,Obadi

更新日期：2019-12-01 00:00:00

abstract：:Pheochromocytoma endures as a life-threatening disorder. In the absence of systemic hypertension, diagnosis may be difficult. We present a 46-year-old normotensive male with a history of presyncope. One of these episodes could be documented, and revealed symptomatic bradycardia suspicious of sinus node arrest. Due to ...

journal_title：Journal of internal medicine

authors： Zweiker R,Tiemann M,Eber B,Schumacher M,Fruhwald FM,Lipp R,Lax S,Pristautz H,Klein W

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:The effect of a second and third generation oral contraceptive and of the progestagens used in these pills on lipid metabolism was studied in the absence or presence of the factor V Leiden mutation. DESIGN:A single centre, double blind randomized trial. SETTING:University Medical Centre. SUBJECTS:A total ...

journal_title：Journal of internal medicine

authors： Kemmeren JM,Algra A,Grobbee DE

更新日期：2001-11-01 00:00:00

abstract：:The relation between obesity, particularly abdominal obesity, and risk of stroke amongst women remains unclear. In 1991-1992, a prospective study was initiated in Sweden amongst women who returned a self-administered questionnaire. Through linkage with nation-wide registries, 45,449 women, free of stroke at entry, wer...

journal_title：Journal of internal medicine

authors： Lu M,Ye W,Adami HO,Weiderpass E

更新日期：2006-11-01 00:00:00