When to initiate and discontinue biologic treatments for rheumatoid arthritis?

abstract：:In order to study the influence of fish oil on CyA-induced renal dysfunction, 13 patients with psoriasis (CyA group) received cyclosporin A (CyA) alone, and seven patients (CyA/EPA + DHA group) received a combination of cyclosporin A and fish oil (6g eicosapentaenoic acid, C20:5 omega-3, and docosahexaenoic acid, C22:...

journal_title：Journal of internal medicine

authors： Stoof TJ,Korstanje MJ,Bilo HJ,Starink TM,Hulsmans RF,Donker AJ

更新日期：1989-12-01 00:00:00

abstract：:Multimorbidity, the simultaneous presence of multiple health conditions in an individual, is an increasingly common phenomenon globally. The systematic assessment of the quality of care delivered to people with multimorbidity will be key to informing the organization of services for meeting their complex needs. Yet, c...

journal_title：Journal of internal medicine

authors： Valderas JM,Gangannagaripalli J,Nolte E,Boyd CM,Roland M,Sarria-Santamera A,Jones E,Rijken M

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To assess the prophylactic efficacy of aspirin and a high-dose antioxidant vitamin combination in patients with peripheral arterial disease (PAD) in terms of reduction of the risk of a first vascular event (myocardial infarction, stroke, vascular death) and critical limb ischaemia. DESIGN:Randomized, placebo...

journal_title：Journal of internal medicine

authors： Critical Leg Ischaemia Prevention Study (CLIPS) Group.,Catalano M,Born G,Peto R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between cardiac repolarization (QT interval duration) and intima media thickness (IMT) of the carotid arteries as surrogate measures of subclinical atherosclerosis. DESIGN:Prospective study with consecutive subjects enrolled in the SAPHIR program (Salzburg Atherosclerosis Pre...

journal_title：Journal of internal medicine

authors： Strohmer B,Pichler M,Iglseder B,Paulweber B

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Pseudoxanthoma elasticum (PXE) is a recessive disorder involving skin, eyes and arteries, mainly caused by ABCC6 pathogenic variants. However, almost one fifth of patients remain genetically unsolved despite extensive genetic screening of ABCC6, as illustrated in a large French PXE series of 220 cases. We searc...

journal_title：Journal of internal medicine

authors： Legrand A,Pujol C,Durand CM,Mesnil A,Rubera I,Duranton C,Zuily S,Sousa AB,Renaud M,Boucher JL,Pietrancosta N,Adham S,Orssaud C,Marelli C,Casali C,Ziccardi L,Villain N,Ewenczyk C,Durr A,Mignot C,Stevanin G,Billon

更新日期：2020-10-27 00:00:00

abstract：:Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in th...

journal_title：Journal of internal medicine

authors： Capitini CM,Chisti AA,Mackall CL

更新日期：2009-08-01 00:00:00

abstract：:A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this re...

journal_title：Journal of internal medicine

authors： Löffler S,Melican K,Nilsson KPR,Richter-Dahlfors A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The angiotensinogen (AGT) gene has been implicated as a candidate gene of high blood pressure. However, because the variants of the AGT gene are point mutations, it is difficult to detect them in large scale population studies. The aims of this study were to develop a rapid screening method for the point mut...

journal_title：Journal of internal medicine

authors： Morise T,Takeuchi Y,Takeda R

更新日期：1995-02-01 00:00:00

abstract：:Studies of zinc status in insulin-dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B-cell. We therefore prospectively followed 26 patients (14 males and 12 femal...

journal_title：Journal of internal medicine

authors： Melchior T,Simonsen KW,Johannessen AC,Binder C

更新日期：1989-07-01 00:00:00

abstract：:Commonly recorded blood analyses as indicators of low- and-high risk patients with lung cancer were studied by comparing symptom- and survey-detected patients. During the period 1976-1985, in 41 of 189 non-small-cell lung cancer patients in Western Norway, lung cancer was detected by chest X-ray survey performed in th...

journal_title：Journal of internal medicine

authors： Hannisdal E,Engan T

更新日期：1991-04-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance...

journal_title：Journal of internal medicine

authors： Turner AR,Kader AK,Xu J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVES:To determine whether mutations in APOA1 affect levels of high-density lipoprotein (HDL) cholesterol and to predict risk of ischaemic heart disease (IHD) and total mortality in the general population. BACKGROUND:Epidemiologically, risk of IHD is inversely related to HDL cholesterol levels. Mutations in apoli...

journal_title：Journal of internal medicine

authors： Haase CL,Frikke-Schmidt R,Nordestgaard BG,Kateifides AK,Kardassis D,Nielsen LB,Andersen CB,Køber L,Johnsen AH,Grande P,Zannis VI,Tybjaerg-Hansen A

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:We aimed to study the effect of social containment mandates on ACS presentation during COVID-19 pandemic using location activity and mobility data from mobile phone map services. METHODS:We conducted a cross-sectional study using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) in...

journal_title：Journal of internal medicine

authors： Mohammad MA,Koul S,Gale CP,Alfredsson J,James S,Fröbert O,Omerovic E,Erlinge D

更新日期：2021-02-01 00:00:00

abstract：:We studied the effect of sleeping in the head-up tilt (HUT) position, alone and in combination with fludrocortisone, on orthostatic tolerance and blood pressure (BP) in six patients with hypoadrenergic orthostatic hypotension. A high salt diet of 150-200 mmol Na+ d-1 was also administered. Combined treatment reduced o...

journal_title：Journal of internal medicine

authors： Ten Harkel AD,Van Lieshout JJ,Wieling W

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult. METHODS:Markers of cardiac stress (B-type natriuretic peptide, BNP) and inflammation (C-reactive protein, white blood cell count, procalcitonin) as well as t...

journal_title：Journal of internal medicine

authors： Christ-Crain M,Breidthardt T,Stolz D,Zobrist K,Bingisser R,Miedinger D,Leuppi J,Tamm M,Mueller B,Mueller C

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline. DESIGN:A population-based, prospective, nested case-referent study. SETTING:Sc...

journal_title：Journal of internal medicine

authors： Hultdin J,Thøgersen AM,Jansson JH,Nilsson TK,Weinehall L,Hallmans G

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic vari...

journal_title：Journal of internal medicine

authors： Luotola K,Pietilä A,Zeller T,Moilanen L,Kähönen M,Nieminen MS,Kesäniemi YA,Blankenberg S,Jula A,Perola M,Salomaa V,Health 2000 and FINRISK97 Studies.

更新日期：2011-03-01 00:00:00

abstract：:The syndrome defined as "idiopathic CD4 lymphocytopenia' (ICL) is a rare disease of unknown aetiology, often associated with severe depression of immune defences and the occurrence of opportunistic infections. A case is reported wherein a severe immunodeficiency syndrome with persistent idiopathic CD4+ lymphopenia dev...

journal_title：Journal of internal medicine

authors： Bordin G,Ballaré M,Paglino S,Ravanini P,Dulio D,Malosso MC,Boldorini R,Monteverde A

更新日期：1996-07-01 00:00:00

abstract：:A 52-year-old white male subject with typical clinical and laboratory findings of Waldenström's macroglobulinaemia is described. Two paraprotein peaks of IgM lambda class, with different physical and chemical properties and different amino acid compositions, in both heavy and light chains, were found in the patient's ...

journal_title：Journal of internal medicine

authors： Ruiz-Palomo F,Revilla Y,Gonzales Porque P,Serrano Rios M

更新日期：1991-01-01 00:00:00

abstract：:Clinical symptoms were studied in 69 consecutive patients below the age of 40 years who were attending the emergency unit because of unexplained chest pain. In a structured interview a few weeks after the emergency visit, only one-third of the patients reported that they believed in the doctor's diagnosis; they believ...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1991-09-01 00:00:00

abstract：:The autoimmune rheumatological diseases rheumatoid arthritis (RA), spondyloarthritis (SpA) and systemic lupus erythematosus (SLE) are treated with conventional immunosuppressive agents and with modern biological immunomodulators. The latter group of medications have brought about a major change in our ability to contr...

journal_title：Journal of internal medicine

authors： van Vollenhoven RF

更新日期：2018-09-01 00:00:00

abstract：:Pheochromocytoma endures as a life-threatening disorder. In the absence of systemic hypertension, diagnosis may be difficult. We present a 46-year-old normotensive male with a history of presyncope. One of these episodes could be documented, and revealed symptomatic bradycardia suspicious of sinus node arrest. Due to ...

journal_title：Journal of internal medicine

authors： Zweiker R,Tiemann M,Eber B,Schumacher M,Fruhwald FM,Lipp R,Lax S,Pristautz H,Klein W

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:Hypocitraturia is a risk factor for calcium nephrolithiasis. 1,25(OH)2D3 influences renal citrate handling and enhances citraturia. The aim of this study was to evaluate the relationship between vitamin D receptor (VDR) allelic variant and urinary citrate excretion in recurrent stone formers (SF) patients. ...

journal_title：Journal of internal medicine

authors： Mossetti G,Vuotto P,Rendina D,Numis FG,Viceconti R,Giordano F,Cioffi M,Scopacasa F,Nunziata V

更新日期：2003-02-01 00:00:00

abstract：:Ebola virus disease (EVD) is a zoonotic disease that causes severe haemorrhagic fever, with high fatality rates of up to 90% in humans. Today, there is no effective treatment available. Person-to-person transmission occurs through exposure to blood or body fluids, which can threaten other household members and first-l...

journal_title：Journal of internal medicine

authors： Mirazimi A

更新日期：2015-09-01 00:00:00

abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...

journal_title：Journal of internal medicine

authors： Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

更新日期：1989-05-01 00:00:00

abstract：:Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic var...

journal_title：Journal of internal medicine

authors： Kaprio J

更新日期：2012-11-01 00:00:00

abstract：:There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and rep...

journal_title：Journal of internal medicine

authors： Kirkwood TB

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients. DESIGN AND SETTING:This double-blind randomised placebo-controlled trial was performed at the dialysis department of...

journal_title：Journal of internal medicine

authors： Diepeveen SH,Verhoeven GW,Van Der Palen J,Dikkeschei LD,Van Tits LJ,Kolsters G,Offerman JJ,Bilo HJ,Stalenhoef AF

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Platelet-activating factor (PAF) is a phospholipid inflammatory mediator which is synthesized by a variety of cells, including monocytes and endothelial cells, and PAF can be retained in activated endothelial cell membranes. Furthermore, PAF-like lipids are produced in other phospholipid membranes as in oxidi...

journal_title：Journal of internal medicine

authors： Wu R,Lemne C,De Faire U,Frostegârd J

更新日期：1999-10-01 00:00:00