Does fish oil protect renal function in cyclosporin-treated psoriasis patients?

Abstract:

:In order to study the influence of fish oil on CyA-induced renal dysfunction, 13 patients with psoriasis (CyA group) received cyclosporin A (CyA) alone, and seven patients (CyA/EPA + DHA group) received a combination of cyclosporin A and fish oil (6g eicosapentaenoic acid, C20:5 omega-3, and docosahexaenoic acid, C22:6 omega-3, daily) for 3 months. The glomerular filtration rate fell by 18.0 +/- 9.6% in the CyA group compared with 8.7 +/- 6.8% in the CyA/EPA + DHA group (mean +/- SD, P less than 0.05). The effective renal plasma flow fell by 10.6 +/- 8.9% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.05). The calculated total renal vascular resistance increased by 19.8 +/- 14.5% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.01). The results of this pilot study suggest that fish oil can reduce CyA-associated renal dysfunction in psoriasis patients.

journal_name

J Intern Med

authors

Stoof TJ,Korstanje MJ,Bilo HJ,Starink TM,Hulsmans RF,Donker AJ

doi

10.1111/j.1365-2796.1989.tb01421.x

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

437-41

issue

6

eissn

0954-6820

issn

1365-2796

journal_volume

226

pub_type

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