The distribution of two different vitamin D receptor polymorphisms (BsmI and start codon) in primary hyperparathyroidism.

abstract：CONTEXT:The classical end-point to terminate the 72-h fast in a patient evaluated for a hypoglycaemic disorder is the occurrence of hypoglycaemic symptoms in association with a low plasma glucose level. However, neither the symptoms nor the plasma glucose level have been exactly defined. OBJECTIVE:To determine whether...

journal_title：Journal of internal medicine

authors： Wiesli P,Brändle M,Schwegler B,Lehmann R,Spinas GA,Schmid C

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVES:Microbial translocation and chronic immune activation were previously shown to be associated with impairment of T cell functions and disease progression during infection with human immunodeficiency virus type-1 (HIV-1); however, their impact on B cell function and number remains unknown. By measuring markers...

journal_title：Journal of internal medicine

authors： Ruffin N,Lantto R,Pensieroso S,Sammicheli S,Hejdeman B,Rethi B,Chiodi F

更新日期：2012-11-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseas...

journal_title：Journal of internal medicine

authors： de Serres F,Blanco I

更新日期：2014-10-01 00:00:00

abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

journal_title：Journal of internal medicine

authors： Maegdefessel L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Lipid-lowering drugs as 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors and cholestyramine are effective in reducing cardiovascular morbidity both in primary and secondary prevention. Patient compliance is an important determinant of the outcome of therapy. This study was designed to co...

journal_title：Journal of internal medicine

authors： Eriksson M,Hådell K,Holme I,Walldius G,Kjellström T

更新日期：1998-05-01 00:00:00

abstract：:The case of a patient with acute occlusion of the right renal artery due to an embolus is described. Using transoesophageal echocardiography, the left atrial appendage could be identified as the source of embolism. Twenty hours after the onset of symptoms, the embolus could be successfully dissolved with an intra-arte...

journal_title：Journal of internal medicine

authors： Mügge A,Gulba DC,Frei U,Wagenbreth I,Grote R,Daniel WG,Lichtlen PR

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA- and IgG seroprevalence in young survivors of myocardial infarction and matched contro...

journal_title：Journal of internal medicine

authors： Halvorsen DS,Børvik T,Njølstad I,Gutteberg TJ,Vorland LH,Hansen JB

更新日期：2002-02-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX are tendon xanthomas, cataracts and progressive neurological dysfunction. Here, we characterize an adult fem...

journal_title：Journal of internal medicine

authors： Hansson M,Olin M,Floren CH,von Bahr S,van't Hooft F,Meaney S,Eggertsen G,Björkhem I

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at...

journal_title：Journal of internal medicine

authors： Fossum E,Gleim GW,Kjeldsen SE,Kizer JR,Julius S,Devereux RB,Brady WE,Hille DA,Lyle PA,Dahlöf B

更新日期：2007-10-01 00:00:00

abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...

journal_title：Journal of internal medicine

authors： Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

更新日期：1989-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV)-associated dementia complex is characterized by difficulties in concentration and memory followed by apathy, social withdrawal and motor dysfunction. Decreased serum vitamin B12 levels occur in up to 20% of patients with acquired immune deficiency syndrome (AIDS) and may adversel...

journal_title：Journal of internal medicine

authors： Herzlich BC,Schiano TD

更新日期：1993-06-01 00:00:00

abstract：:Ten adult patients with a severe nephrotic syndrome resistant to conventional immunosuppression were treated with cyclosporin A (CyA) for a mean period of 11 months. CyA was effective in all but two patients, as evaluated by 24-h urine protein excretion and clinical appearance. In general the best effect of CyA was se...

journal_title：Journal of internal medicine

authors： Nyrop M,Olgaard K

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Benefit from endovascular thrombectomy (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) is well demonstrated. Furthermore, emerging evidence supports efficacy in appropriately selected patients treated beyond current recommendations of 6 h. We evaluated clinical outcomes in ...

journal_title：Journal of internal medicine

authors： Motyer R,Kok HK,Asadi H,O'Hare A,Brennan P,Power S,Looby S,Nicholson P,Williams D,Murphy S,Hill MD,Goyal M,McManus J,O'Brien P,Thornton J

更新日期：2017-12-01 00:00:00

abstract：:The onset of human disease by infection with SARS-CoV-2 causing COVID-19 has revealed risk factors for disease severity. There are four identified factors that puts one at high-risk for infection and/or mortality creating a disparity: age, comorbidities, race/ethnicity, and gender. Data indicate that the older a perso...

journal_title：Journal of internal medicine

authors： Carethers JM

更新日期：2020-11-08 00:00:00

abstract：:Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well-documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase-derived prostaglandins which act to modulate pathologic processes that would normally imp...

journal_title：Journal of internal medicine

authors： Gambaro G,Perazella MA

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Study patient characteristics, morbidity patterns and drug regimens associated with fatal adverse drug events (FADEs) amongst medical department inpatients. DESIGN:An observational, descriptive study using aggregated medical records, autopsies and pre and postmortem drug analyses. SETTING:A department of in...

journal_title：Journal of internal medicine

authors： Buajordet I,Ebbesen J,Erikssen J,Brørs O,Hilberg T

更新日期：2001-10-01 00:00:00

abstract：:We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use...

journal_title：Journal of internal medicine

authors： Punthakee Z,Scully LJ,Guindi MM,Ooi TC

更新日期：2001-09-01 00:00:00

abstract：:The relation between obesity, particularly abdominal obesity, and risk of stroke amongst women remains unclear. In 1991-1992, a prospective study was initiated in Sweden amongst women who returned a self-administered questionnaire. Through linkage with nation-wide registries, 45,449 women, free of stroke at entry, wer...

journal_title：Journal of internal medicine

authors： Lu M,Ye W,Adami HO,Weiderpass E

更新日期：2006-11-01 00:00:00

abstract：:For nearly a decade since the mapping of the multiple endocrine neoplasia type 1 (MEN1) locus to 11q13 and the suggestion that it is a tumour suppressor gene, efforts have been made to identify the gene responsible for this familial cancer syndrome. Recently, we have identified the MEN1 gene by the positional cloning ...

journal_title：Journal of internal medicine

authors： Guru SC,Manickam P,Crabtree JS,Olufemi SE,Agarwal SK,Debelenko LV

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline. DESIGN:A population-based, prospective, nested case-referent study. SETTING:Sc...

journal_title：Journal of internal medicine

authors： Hultdin J,Thøgersen AM,Jansson JH,Nilsson TK,Weinehall L,Hallmans G

更新日期：2004-12-01 00:00:00

abstract：:The acquired immunodeficiency syndrome (AIDS) has been associated with abnormalities of adrenocortical function, and hypoaldosteronism due to hyporeninaemic hypoaldosteronism (HHA). We here report the case of a woman with AIDS associated with orthostatic hypotension, persistent hyponatraemia and hyperkalaemia, in whom...

journal_title：Journal of internal medicine

authors： Cobbs R,Pepper GM,Torres JG,Gruenspan HL

更新日期：1991-08-01 00:00:00

abstract：:Gene mutations at the low density lipoprotein (LDL) receptor locus were screened in 210 alleles of Japanese patients with familial hypercholesterolaemia (FH). In the present study, two types of novel mutation were identified by genomic Southern blotting using human LDL receptor cDNA probes. An approximately 12 kb dele...

journal_title：Journal of internal medicine

authors： Kajinami K,Mabuchi H,Inazu A,Fujita H,Koizumi J,Takeda R,Matsue T,Kibata M

更新日期：1990-04-01 00:00:00

abstract：:The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained f...

journal_title：Journal of internal medicine

authors： Segal AW

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Echocardiographically determined left atrioventricular plane displacement (AVPD) is strongly related to prognosis in patients with chronic heart failure and in postmyocardial infarction patients. We aimed at exploring whether AVPD, unlike ejection fraction, is related to mortality in patients with stable cor...

journal_title：Journal of internal medicine

authors： Rydberg E,Erhardt L,Brand B,Willenheimer R

更新日期：2003-11-01 00:00:00

abstract：:Hip fractures in the elderly represent a global issue, associated with significant morbidity and mortality. Considering the magnitude of the problem, any substantial reduction in the hip fracture burden depends on prevention. In view of the complex pathogenesis of senile (type II) osteoporosis, preventive strategies s...

journal_title：Journal of internal medicine

authors： Boonen S,Dequeker J

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:The aim was to study the effect of a 5-year diet intervention on 24-year mortality in middle aged men with combined hyperlipidaemia. SETTING:We studied 104 initially healthy men (in 1972) aged 40-49 years with baseline values of total serum cholesterol >6.45 mmol L-1 and fasting triglycerides >2.55 mmol L-1...

journal_title：Journal of internal medicine

authors： Hjerkinn EM,Sandvik L,Hjermann I,Arnesen H

更新日期：2004-01-01 00:00:00

abstract：:When and where did modern humans evolve? How did our ancestors spread over the world? Traditionally, answers to questions such as these have been sought in historical, archaeological, and fossil records. However, increasingly genetic data provide information about the evolution of our species. In this review, we focus...

journal_title：Journal of internal medicine

authors： Kaessmann H,Pääbo S

更新日期：2002-01-01 00:00:00

abstract：:During the long history of development of haemoglobin (Hb)-based O2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with...

journal_title：Journal of internal medicine

authors： Sakai H,Sou K,Horinouchi H,Kobayashi K,Tsuchida E

更新日期：2008-01-01 00:00:00

abstract：:Recent observed changes in Earth's climate, to which humans have contributed substantially, are affecting various health outcomes. These include altered distributions of some infectious disease vectors (ticks at high latitudes, malaria mosquitoes at high altitudes), and an uptrend in extreme weather events and associa...

journal_title：Journal of internal medicine

authors： McMichael AJ,Lindgren E

更新日期：2011-11-01 00:00:00