A plasma glucose concentration below 2.5 mmol L-1 is not an appropriate criterion to end the 72-h fast.

Abstract:

CONTEXT:The classical end-point to terminate the 72-h fast in a patient evaluated for a hypoglycaemic disorder is the occurrence of hypoglycaemic symptoms in association with a low plasma glucose level. However, neither the symptoms nor the plasma glucose level have been exactly defined. OBJECTIVE:To determine whether a useful cut-off plasma glucose concentration as criterion to end the prolonged fast in the absence of neuroglycopenic symptoms can be defined. DESIGN:Single centre case-control study. SETTING:Tertiary referral hospital in Switzerland. SUBJECTS:The 72-h fast was prospectively performed in 23 consecutive patients (17 women and six men) following a standardized protocol between July 1999 and January 2002. All patients were referred to our clinic for evaluation of suspected hypoglycaemia. The criterion to end the fast before 72 h was defined by the occurrence of symptoms or signs typical for neuroglycopenia irrespective of plasma glucose levels. MAIN OUTCOME MEASURE:Insulin levels and insulin to plasma glucose ratios in insulinoma patients and in individuals without insulin-secreting tumours at termination of the fast and at plasma glucose levels

journal_name

J Intern Med

authors

Wiesli P,Brändle M,Schwegler B,Lehmann R,Spinas GA,Schmid C

doi

10.1046/j.1365-2796.2002.01060.x

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

504-9

issue

6

eissn

0954-6820

issn

1365-2796

pii

1060

journal_volume

252

pub_type

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