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Acquired total immunoglobulin G deficiency in a patient with primary biliary cirrhosis.

Abstract：

:A 38-year-old Japanese woman was hospitalized for susceptibility to respiratory tract infections. Clinical examinations revealed asymptomatic primary cholestasis, abnormally elevated immunoglobulin M (IgM) and antimitochondrial antibody, being consistent with asymptomatic primary biliary cirrhosis. Three years later her serum immunoglobulin G (IgG) decreased remarkably, whereas other immunoglobulins were unchanged. Immunological examinations on the peripheral blood lymphocytes demonstrated spontaneous over-synthesis of serum IgM and decreased synthesis of IgG due to abnormal function of both T and B cells. Our case suggests a new possible association between primary biliary cirrhosis and IgG deficiency.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Take H,Kubota K,Tamura K,Kurabayashi H,Tamura J,Shirakura T

doi

10.1111/j.1365-2796.1995.tb00936.x

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

289-92

issue

3

eissn

0954-6820

issn

1365-2796

journal_volume

238

pub_type

杂志文章

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