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Helicobacter pylori: resurrection of the cancer link.

Abstract：

:Helicobacter pylori is one of the most common pathogenic bacterial infections, colonizing an estimated half of all humans. In a subset of individuals, the infection leads to serious gastroduodenal disease such as peptic ulcers and gastric adenocarcinoma. The factors contributing to skewing this, in most cases benign, relationship into disease development are largely unknown. However, factors emanating from the bacterium, host and the environment have been shown to affect the risk for disease, although no factor can be singled out to be most important. The known factors are associated with affecting the risk of disease, and are not absolute. Virulence of H. pylori is affected by the existence and regulation of certain genes present in the bacterial population in a stomach. The effects of H. pylori on gastric cancer development have been challenged and the risk associated with infection with virulent (i.e. Cag PAI positive) H. pylori has likely been underestimated.

journal_name

J Intern Med

journal_title

Journal of internal medicine

authors

Björkholm B,Falk P,Engstrand L,Nyrén O

doi

10.1046/j.1365-2796.2003.01119.x

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

102-19

issue

2

eissn

0954-6820

issn

1365-2796

pii

1119

journal_volume

253

pub_type

杂志文章,评审

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