Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma.

abstract：:During a 10-year period 39 patients with acromegaly, aged 23-73 years, underwent selective adenomectomy via a trans-sphenoidal or transfrontal (one case) approach. Six to 12 months after the operation, the serum level of growth hormone (GH) was reduced to less than 5 micrograms l-1 in 28 patients (74%) in at least two...

journal_title：Journal of internal medicine

authors： Valdemarsson S,Bramnert M,Cronquist S,Elner A,Eneroth CM,Hedner P,Lindvall-Axelsson M,Nordström CH,Strömblad LG

更新日期：1991-07-01 00:00:00

abstract：:Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the followi...

journal_title：Journal of internal medicine

authors： Rosen MR,Cohen IS

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between the pituitary-adrenocortical function, abdominal obesity, and insulin resistance syndrome. DESIGN:A prospective study. SETTING:Helsinki University Hospital, Finland. SUBJECTS:Sixty-six healthy males aged 30-55 years. MAIN OUTCOME MEASURES:Insulin, C-peptide, cortis...

journal_title：Journal of internal medicine

authors： Hautanen A,Adlercreutz H

更新日期：1993-11-01 00:00:00

abstract：:Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are requ...

journal_title：Journal of internal medicine

authors： Rej A,Aziz I,Sanders DS

更新日期：2020-11-01 00:00:00

abstract：:The association between dental infections and cerebral infarction was investigated in a case-control study involving 40 patients with ischaemic cerebral infarction under the age of 50, and 40 randomly selected community controls matched for sex and age. Poor oral health, as assessed by two indices measuring the severi...

journal_title：Journal of internal medicine

authors： Syrjänen J,Peltola J,Valtonen V,Iivanainen M,Kaste M,Huttunen JK

更新日期：1989-03-01 00:00:00

abstract：:Clonal haematopoiesis results from acquired mutations in haematopoietic stem and progenitor cells (HSPCs). These mutations can confer the HSPC with a competitive advantage, leading to their clonal expansion within the limiting bone marrow niche. This process is often insufficient to produce a haematologic malignancy; ...

journal_title：Journal of internal medicine

authors： Min KD,Kour A,Sano S,Walsh K

更新日期：2020-11-01 00:00:00

abstract：AIM:Prevalence, optimal diagnostic approach and consequences of clinically unsuspected osteomyelitis in diabetic foot ulcers are unclear. Early diagnosis of this infection may be crucial to ensure correct management. METHODS:We conducted a prospective study in 20 diabetic patients with a chronic foot ulcer (>8 weeks) ...

journal_title：Journal of internal medicine

authors： Schwegler B,Stumpe KD,Weishaupt D,Strobel K,Spinas GA,von Schulthess GK,Hodler J,Böni T,Donath MY

更新日期：2008-01-01 00:00:00

abstract：:Twenty-six consecutive patients with primary biliary cirrhosis (PBC) from northern Sweden were studied regarding the occurrence and features of Sjögren's syndrome (SS). In more than 50% of the patients the rose bengal dye test showed conjunctival and/or corneal staining. In six patients keratoconjunctivitis sicca (KCS...

journal_title：Journal of internal medicine

authors： Uddenfeldt P,Danielsson A,Forssell A,Holm M,Ostberg Y

更新日期：1991-11-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX are tendon xanthomas, cataracts and progressive neurological dysfunction. Here, we characterize an adult fem...

journal_title：Journal of internal medicine

authors： Hansson M,Olin M,Floren CH,von Bahr S,van't Hooft F,Meaney S,Eggertsen G,Björkhem I

更新日期：2007-05-01 00:00:00

abstract：:Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency, and by reducing surgical trauma, several observational studies suggest potentia...

journal_title：Journal of internal medicine

authors： Kastengren M,Svenarud P,Ahlsson A,Dalén M

更新日期：2019-12-01 00:00:00

abstract：:We determined whether ketoconazole prophylaxis might reduce Candida colonization and infections in adult patients with acute leukaemia. During first-remission induction therapy 50 patients were treated with 200 mg ketoconazole administered orally daily, while 57 patients received placebo in a double-blind, randomized ...

journal_title：Journal of internal medicine

authors： Palmblad J,Lönnqvist B,Carlsson B,Grimfors G,Järnmark M,Lerner R,Ljungman P,Nyström-Rosander C,Petrini B,Oberg G

更新日期：1992-04-01 00:00:00

abstract：:Cancer is a genetic disease caused by 'gain of function' mutations of oncogenes and 'loss of function' mutations of tumour suppressors and of genes involved in DNA repair mechanisms. The RET gene encodes a tyrosine kinase receptor for molecules belonging to the glial cell line-derived neurotrophic factor (GDNF) family...

journal_title：Journal of internal medicine

authors： Santoro M,Melillo RM,Carlomagno F,Visconti R,De Vita G,Salvatore G,Lupoli G,Fusco A,Vecchio G

更新日期：1998-06-01 00:00:00

abstract：:A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this re...

journal_title：Journal of internal medicine

authors： Löffler S,Melican K,Nilsson KPR,Richter-Dahlfors A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the prognostic value of exercise testing performed soon after acute myocardial infarction (AMI) in patients treated with thrombolytic therapy. DESIGN:A 1-year prospective follow-up of 185 subjects treated with thrombolytic therapy who survived AMI, and who performed exercise testing 3 weeks afte...

journal_title：Journal of internal medicine

authors： Abboud L,Hir J,Eisen I,Markiewicz W

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding fo...

journal_title：Journal of internal medicine

authors： Holm J,Zöller B,Berntorp E,Erhardt L,Dahlbäck B

更新日期：1996-03-01 00:00:00

abstract：AIM:There is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations betw...

journal_title：Journal of internal medicine

authors： Kautzky-Willer A,Thurner S,Klimek P

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：:Coronary heart disease (CHD) has its origin in childhood. High cholesterol levels measured in children and adolescents are indicative of concurrent atherosclerotic changes and probably predict adult coronary heart disease. We review here the relevance of screening children, adolescents or young adults for serum lipid ...

journal_title：Journal of internal medicine

authors： Porkka KV,Viikari JS

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVES:to examine fatigue variability over time in chronic fatigue syndrome (CFS) and the effect of other symptoms on its predictability. DESIGN:longitudinal cohort study of patients with CFS (Fukuda criteria). SETTING:specialist CFS clinical service. SUBJECTS:phase 1: 100 patients who participated in a study of...

journal_title：Journal of internal medicine

authors： Jones DE,Gray J,Frith J,Newton JL

更新日期：2011-02-01 00:00:00

abstract：:The therapeutic effect of an elemental diet (Pepti 2000) and blended normal diet (placebo) was investigated in 43 out-patients with chronic inflammatory bowel disease (IBD); 24 with ulcerative colitis (UC) and 19 with Crohn's disease (CD), in a mild to moderate state of disease activity. A pilot study on healthy volun...

journal_title：Journal of internal medicine

authors： Munkholm Larsen P,Rasmussen D,Rønn B,Munck O,Elmgreen J,Binder V

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology, pathogenesis and clinical features of hepatocellular carcinoma (HCC) in patients with acute intermittent porphyria (AIP). DESIGN:A retrospective population-based mortality study. SUBJECTS:All inhabitants who died between 1978-1990 (2122) including 33 with AIP, in two municipali...

journal_title：Journal of internal medicine

authors： Andersson C,Bjersing L,Lithner F

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVES:Chronic Chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (MIF) test. We wanted to investigate the C. pneumoniae IgA- and IgG seroprevalence in young survivors of myocardial infarction and matched contro...

journal_title：Journal of internal medicine

authors： Halvorsen DS,Børvik T,Njølstad I,Gutteberg TJ,Vorland LH,Hansen JB

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:To investigate the risk of ipsilateral versus contralateral recurrent deep vein thrombosis in the leg. DESIGN:An open prospective long term follow-up multicentre trial. Patients were followed by frequent outpatient visits at each centre during the first 12 months after inclusion and thereafter annually. SE...

journal_title：Journal of internal medicine

authors： Lindmarker P,Schulman S

更新日期：2000-05-01 00:00:00

abstract：:Evaluation of pro-oxidant/antioxidant dietary factors in relation to individual susceptibility to cancer and cardiovascular disease is justified based on a review of the literature. This working hypothesis is amendable to further scientific validation from biomarkers with end-point sensitivity to oxygen radicals. So f...

journal_title：Journal of internal medicine

authors： Pero RW,Berglund G,Christie NT,Cosma GN,Frenkel K,Garte SJ,Janzon L,Olsson A,Seidegård J,Smulson ME

更新日期：1993-01-01 00:00:00

abstract：:We describe the clinical course of a 58-year-old man who died from acute papillary muscle rupture as a complication of clostridial sepsis. There was no evidence for myocardial infarction, infective endocarditis, prior chest trauma or other known causes of papillary muscle rupture. Histological specimens taken at autop...

journal_title：Journal of internal medicine

authors： Schulz R,Andreas S,Weise B,Werner GS

更新日期：1997-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of acquired disability globally, and effective treatment methods are scarce. Lately, there has been increasing recognition of the devastating impact of TBI resulting from sports and other recreational activities, ranging from primarily sport-related concussions (SRC) but a...

journal_title：Journal of internal medicine

authors： Marklund N,Bellander BM,Godbolt AK,Levin H,McCrory P,Thelin EP

更新日期：2019-06-01 00:00:00

abstract：:The association of sex, age, relative weight, smoking and drinking habits, chronic obstructive pulmonary disease (COPD) and economic and marital status, with benign oesophageal disease (BOD) was investigated by means of a point-prevalence study of BOD in a Danish population. A total of 346 individuals, representing su...

journal_title：Journal of internal medicine

authors： Andersen LI,Jensen G

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Lymphangioleiomyomatosis (LAM) can occur as in isolated form (sporadic LAM) or as a pulmonary manifestation of tuberous sclerosis complex (TSC) (TSC-associated LAM). Recent studies, however, revealed that both forms of LAM are genetically related but that sporadic LAM is a distinct clinical entity caused by ...

journal_title：Journal of internal medicine

authors： Sato T,Seyama K,Kumasaka T,Fujii H,Setoguchi Y,Shirai T,Tomino Y,Hino O,Fukuchi Y

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:To determine whether furosemide treatment in congestive heart failure (CHF) patients is associated with thiamine deficiency. DESIGN:Patients without heart failure and without diuretic treatment were included to compare with patients with CHF belonging to New York Heart Association (NYHA) functional class II...

journal_title：Journal of internal medicine

authors： Yue QY,Beermann B,Lindström B,Nyquist O

更新日期：1997-12-01 00:00:00

abstract：:We describe a 22-year-old female with systemic lupus erythematosus and lymphopenia, who developed septic arthritis of the right knee with Listeria monocytogenes type 1/2 A, whilst on low-dose methotrexate (MTX). So far, septic arthritis due to this microorganism has been reported in two other patients treated with low...

journal_title：Journal of internal medicine

authors： Jansen TL,van Heereveld HA,Laan RF,Barrera P,van de Putte LB

更新日期：1998-07-01 00:00:00